Anti-Aging Efficacy of Melatonin-Based Cream: Clinical and Instrumental Skin Evaluation

Abstract

Background: Melatonin is a potent mitochondrial, cytoprotective and antioxidant molecule with potentially strong anti-aging properties. Topical melatonin has shown to improve the clinical signs of skin aging. Melatosphere™ is a new lipid-based delivery system able to improve stability and skin penetration of melatonin when used in topical formulations. No clinical studies, using objective instrumental data, are available so far regarding the positive effect of Melatosphere™ in improving wrinkles in women with mild-to-moderate skin aging. Study Aim: We evaluate, in an open prospective, evaluatorblinded trial, the effects on skin texture of 2 months treatment with a Melatosphere™ based cream. Subjects and Methods: 15 women aged >45 years with mild to moderate facial skin aging (Glogau score ≥2) participated in the trial, after their informed consent.An ANTERA 3D computer-assisted skin analysis evaluation for the assessment of coarse and fine wrinkles of the periorbital area and melanin content was performed at baseline and after two months of treatment. An evaluator-blinded Investigator Global assessment of skin elastosis, roughness, level of dyscromia, skin dryness and presence of actinic damage was also performed at the same time points using a 4-grade score from 0 (no sign) to 3 (severe sign). Results: At baseline the mean (SD) IGA score was 8.2(1.0). After 2 months the IGA score significantly decrease to 4.2(1.4) (49% reduction) (P=0.0007).ANTERA 3D evaluations showed a significant reduction in skin coarse and fine wrinkles volume in the target area of -31% and -18%, respectively. Melanin content was reduced significantly by -17%. Conclusion: Topical melatonin carried in Melatosphere improves in the short-term signs of skin aging evaluated clinically and by ANTERA 3D device in women with mild to moderate skin aging.

Physiological crosstalk between the Mel1a and Mel1c pathways modulates melatonin-mediated, monochromatic light combination-induced bursa B-lymphocyte proliferation in chickens

“…In addition, the melatonin main biologically active metabolite, AFMK can stimulate differentiation in human epidermis and promote epidermal barrier formation [34]. Milani et al also found melatonin and its metabolites act as free radical scavengers could improve signs of skin aging evaluated clinically [35]. Thus, we inferred G→B not only increased the melatonin concentration but also lead to the accumulation of melatonin metabolites in plasma.…”

Truths and myths about marketed anti-aging skin products: a systematic review

“…[16][17][18] The three studies were recently published between 2018 and 2017. [16][17][18] The aim of the three studies were checked, two studies investigated the effect of anti-aging products on the skin, one study investigated the effect of using melatospherebased cream for two months on skin texture and the other study evaluated the efficacy of topical products including night and day facial creams, night and day lip creams and eye creams to reduce the appearance of wrinkles and transepidermal water loss and to increase skin moisturization. 16,17 The last study investigated the efficacy of different types of anti-aging products but relied on data obtained from self-assessment of customers.…”

“…[16][17][18] The aim of the three studies were checked, two studies investigated the effect of anti-aging products on the skin, one study investigated the effect of using melatospherebased cream for two months on skin texture and the other study evaluated the efficacy of topical products including night and day facial creams, night and day lip creams and eye creams to reduce the appearance of wrinkles and transepidermal water loss and to increase skin moisturization. 16,17 The last study investigated the efficacy of different types of anti-aging products but relied on data obtained from self-assessment of customers. 18 There were two trials included, each of the three studies was of a different study design, one of the trials was an open, prospective evaluator-blinded trial, the other trial was controlled clinical and the third study was a prospective cross-sectional study.…”

“…18 There were two trials included, each of the three studies was of a different study design, one of the trials was an open, prospective evaluator-blinded trial, the other trial was controlled clinical and the third study was a prospective cross-sectional study. [16][17][18] The total number of included participants was 192 women, one trial included 50 women age older than 45 years with mild to moderate facial skin aging, the other trial included only five women tested for the efficacy of five products, the third study was conducted on 137 females with age older than 35 years and used anti-aging products for at least two months. [16][17][18] Only two articles stated their assessment tools.…”

“…[16][17][18] The total number of included participants was 192 women, one trial included 50 women age older than 45 years with mild to moderate facial skin aging, the other trial included only five women tested for the efficacy of five products, the third study was conducted on 137 females with age older than 35 years and used anti-aging products for at least two months. [16][17][18] Only two articles stated their assessment tools. One trial reported using Antera 3D cameras and Investigator global assessment (IGA), the former was to evaluate the coarse and fine wrinkles of the periorbital area and the melanin content, whereas the latter was to assess the level of elastosis, roughness, dyschromia, skin dryness and actinic damage.…”