Antiaging Action of Retinol: From Molecular to Clinical

Bellemère, Gaëlle; Stamatas, Georgios N.; Bruère, Valérie; Bertin, Christiane; Issachar, N.; Oddos, Thierry

doi:10.1159/000231525

Cited by 59 publications

(44 citation statements)

References 72 publications

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“…anti-aging creams) has not produced any harmful effects -apart from the small number of allergic reactions described in several studies [1] . Such findings are not surprising as cosmetic products are developed for continuous long-term application with lower antioxidant concentrations than products intended for medical treatment [46] .…”

Section: Antioxidants In Medical and Cosmetic Treatmentsmentioning

confidence: 97%

Uptake of Antioxidants by Natural Nutrition and Supplementation: Pros and Cons from the Dermatological Point of View

Lademann

Patzelt

Schanzer

et al. 2011

Skin Pharmacol Physiol

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The pros and cons of the systemic and topical application of antioxidant substances are a subject of intense discussion among experts, with resulting confusion for consumers and producers. The objective of the present article is to clarify the various uncertainties relating to the use of antioxidant substances in dermatology. Whereas inappropriate application of antioxidant substances (concerning their concentration and composition) might induce harmful effects, the consumer will definitively benefit from physiological concentrations and compositions of antioxidants. The most suitable method is the consumption of natural antioxidants in the form of fruit and vegetables, for example. In addition, the skin, which also accumulates antioxidant substances, may profit from a sufficient antioxidative level, as damage induced by sun radiation in addition to skin aging is reduced.

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Section: Antioxidants In Medical and Cosmetic Treatmentsmentioning

confidence: 97%

Uptake of Antioxidants by Natural Nutrition and Supplementation: Pros and Cons from the Dermatological Point of View

Lademann

Patzelt

Schanzer

et al. 2011

Skin Pharmacol Physiol

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“…In a finite element modelling context, it implies that using a single set of mechanical properties for the stratum corneum would limit the domain of validity of the simulation results to specific conditions. A wide array of experimental and clinical measurement techniques are used to characterise particular aspects of skin biology and biophysics (Alexiades-Armenakas, 2007;Batisse et al, 2002;Bellemere et al, 2009;Delalleau et al, 2006;Diridollou et al, 2000;Gunner et al, 1979;Hendriks et al, 2006;Jor et al, 2013;Limbert and Simms, 2013;Tonge et al, 2013a;Tonge et al, 2013b;Wan Abas, 1994). Nevertheless, complementary approaches based on mathematical and computational modelling techniques offer promising avenues to further our understanding of the skin (Areias et al, 2003;Bischoff et al, 2000;Boissieux et al, 2000;Buganza Tepole and Kuhl, 2014;Cavicchi et al, 2009;Duan et al, 2000;Evans, 2009;Flynn and McCormack, 2008a, b;Flynn andMcCormack, 2009, 2010;Hendriks et al, 2006;Hendriks et al, 2003;Kuwazuru et al, 2008;Larrabee and Galt, 1986a, b;Larrabee and Sutton, 1986;Lévêque and Audoly, 2013;Tepole et al, 2014a;Tepole et al, 2014b;Tepole et al, 2011;Zöllner et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

A mechanistic insight into the mechanical role of the stratum corneum during stretching and compression of the skin

Leyva-Mendivil

Page

Bressloff

et al. 2015

Journal of the Mechanical Behavior of Biomedical Materials

109

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A mechanistic insight into the mechanical role of the stratum corneum during stretching and compression of the skin. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.www.elsevier.com/locate/jmbbm 1 A mechanistic insight into the mechanical role of the stratum corneum during stretching and compression of the skin. AbstractThe study of skin biophysics has largely been driven by consumer goods, biomedical and cosmetic industries which aim to design products that efficiently interact with the skin and/or modify its biophysical properties for health or cosmetic benefits. The skin is a hierarchical biological structure featuring several layers with their own distinct geometry and mechanical properties. Up to now, no computational models of the skin have simultaneously accounted for these geometrical and material characteristics to study their complex biomechanical interactions under particular macroscopic deformation modes.The goal of this study was, therefore, to develop a robust methodology combining histological sections of human skin, image-processing and finite element techniques to address fundamental questions about skin mechanics and, more particularly, about how macroscopic strains are transmitted and modulated through the epidermis and dermis. The work hypothesis was that, as skin deforms under macroscopic loads, the stratum corneum does not experience significant strains but rather folds/unfolds during skin extension/compression.A sample of fresh human mid-back skin was processed for wax histology. Sections were stained and photographed by optical microscopy. The multiple images were stitched together to produce a larger region of interest and segmented to extract the geometry of the stratum corneum, viable epidermis and dermis. From the segmented structures a 2D finite element mesh of the skin composite model was created and geometrically non-linear plane-strain finite element analyses were conducted to study the sensitivity of the model to variations in mechanical properties.The hybrid experimental-computational methodology has offered valuable insights into the simulated mechanics of the skin, and that of the stratum corneum in particular, by providing qualitative and quantitative information on strain magnitude and distribution. Through a complex non-linear interplay, the geometry and mechanical characteristics of the skin layers (and their relative balance), play a critical role in conditioning the skin mechanical response to macroscopic in-plane compression and extension. Topographical features of the skin surface such as furrows were shown to act as an efficient means to deflec...

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“…chronological aging. In the past, we have demonstrated that lower concentration of retinol (0.1%) also delivers beneficial result on skin photoaging signs [33,34]. Even more, in the study described in this paper, we have demonstrated that the clinical efficacy of retinol could be achieved with a concentration of retinol as low as 0.04% by using it in combination with a chromone derivative and low molecular weight fragments of hyaluronic acid.…”

Section: Discussionmentioning

confidence: 71%

A Placebo-Controlled Study Demonstrates the Long-Lasting Anti-Aging Benefits of a Cream Containing Retinol, DihydroxyMethylChromone (DMC) and Hyaluronic Acid

Oddos¹,

Roure²,

Leyden³

et al. 2012

JCDSA

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Retinol is an ingredient used in cosmetic products for reducing the appearance of the signs of aging and photo-damage. Currently, most of these products contain 0.1% of retinol. However, at this concentration, some irritation can occur. We have evaluated in vitro and in a clinical study the potential efficacy of a combination of actives to improve the facial skin aging signs while using low concentration of retinol. We demonstrated, in vitro, that a chromone derivative, 5,7-di-hydroxy-2-methyl chromone (DMC), is able to enhance the collagen synthesis in culture of normal human dermal fibroblasts. The enhancement of retinol anti-wrinkle efficacy by DMC was confirmed in a small scale clinical trial. Specifically, a product associating low concentration of retinol (0.04%) and DMC (0.1%) in combination with low molecular weight hyaluronic acid fragments (50,000 Dalton of average molecular weight) has been applied topically for 8 weeks. Clinical results show significant improvement of various signs of facial skin aging such as wrinkles, pigmentary spots, tone unevenness, dullness and the overall photo-damage score. Improvements were still visible 4 weeks after the cessation of the test product application. This study demonstrates that significant lasting improvement of facial skin aging can be obtained with well tolerated low concentration of retinol when adequately formulated with other anti-aging ingredients.

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Antiaging Action of Retinol: From Molecular to Clinical

Cited by 59 publications

References 72 publications

Uptake of Antioxidants by Natural Nutrition and Supplementation: Pros and Cons from the Dermatological Point of View

Uptake of Antioxidants by Natural Nutrition and Supplementation: Pros and Cons from the Dermatological Point of View

A mechanistic insight into the mechanical role of the stratum corneum during stretching and compression of the skin

A Placebo-Controlled Study Demonstrates the Long-Lasting Anti-Aging Benefits of a Cream Containing Retinol, DihydroxyMethylChromone (DMC) and Hyaluronic Acid

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