Antiadipogenic Effects of<i>Aster glehni</i>Extract: In Vivo and In Vitro Effects

Lee, Heon-Myeong; Yang, Gabsik; Ahn, Tae-Gue; Kim, Myung-Dong; Nugroho, Agung; Park, Hee-Juhn; Lee, Kyung‐Tae; Park, Wan-Su; An, Hyo‐Jin

doi:10.1155/2013/859624

Cited by 30 publications

(14 citation statements)

References 32 publications

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“…36 In this study the expression of aP2 and LPL was significantly down-regulated in a dose-dependent manner by OPE treatment following an increase in C/EBP and PPAR . 37 Our wileyonlinelibrary.com/jsfa result is in agreement with the study of Moon et al 38 showing aP2-inhibitory activity of OPE.…”

Section: Discussionsupporting

confidence: 92%

Quercetin-rich onion peel extract suppresses adipogenesis by down-regulating adipogenic transcription factors and gene expression in 3T3-L1 adipocytes

Bae

Park

Cha

2014

J. Sci. Food Agric.

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Section: Discussionsupporting

confidence: 92%

Quercetin-rich onion peel extract suppresses adipogenesis by down-regulating adipogenic transcription factors and gene expression in 3T3-L1 adipocytes

Bae

Park

Cha

2014

J. Sci. Food Agric.

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“…There is a growing body of literature that recognizes the importance of excess fat intake on immune reactions, chronic inflammation, and CRC [19]. Previous research has found that diet-induced obesity accelerates colon tumor formation, suggesting the contributions of inflammation to tumorigenesis in the HFD-enhanced CRC murine model [20].…”

Section: Discussionmentioning

confidence: 99%

“…Aster glehni (AG) extracts were prepared as described previously [18,19]. The dried material was refluxed with 70% EtOH for 6 h at 60 • C. The extract was filtered (Whatman Qualitative Filter Paper no.…”

Section: Preparation and Standardization Of The Extract Of Agmentioning

confidence: 99%

High-Fat Diet Propelled AOM/DSS-Induced Colitis-Associated Colon Cancer Alleviated by Administration of Aster glehni via STAT3 Signaling Pathway

Jin

Chung

Lee

et al. 2020

Biology

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Many epidemiological observational studies suggest that a high-fat diet (HFD) accelerates the risk of colorectal cancer (CRC). Inflammation can play a key role in the relationship between colon cancer and HFD. Although reported by several studies, controlled experimental studies have not explored this relationship. We established an HFD-fed colitis-associated colon cancer (CAC) mice model and evaluated the anti-tumorigenic effects of AG on HFD-propelled CAC along with its mechanism of action. Previously, we found that Aster glehni (AG) exerts chemopreventive effects on azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced CAC in a mice model, and has anti-adipogenic effects in a HFD-induced obesity mice model. In the HFD-propelled CAC mice model, AG significantly reduced cancer-related death, prevented body weight loss, and alleviated splenic enlargement. Additionally, AG prevented colon shortening and reduced the number of colorectal polyps. Histological studies demonstrated the up-regulation of inflammation, hyperplasia, and neoplasia in HFD-propelled CAC mice, whereas AG suppressed colonic disease progression and tumorigenesis. Furthermore, AG significantly inhibited the signal transducer and activator of transcription 3 (STAT3) signaling pathway and attenuated the protein expression of the STAT3 target gene, which mediates transcription factor-dependent tumor cell proliferation. These results indicate that AG abrogates inflammation-induced tumor progression in HFD-propelled CAC mice by inhibiting STAT3 activation.

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“…A. glehni (AG) extracts were prepared as described previously [ 9 ]. The dried material was refluxed with 70% EtOH for 6 h at 60 °C.…”

Section: Methodsmentioning

confidence: 99%

Chemopreventive Effect of Aster glehni on Inflammation-Induced Colorectal Carcinogenesis in Mice

et al. 2018

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Although Aster glehni is a common dietary herb that has various bioactivities, including anti-diabetic, anti-adipogenic, and anti-inflammatory effects, A. glehni has not been studied in colon cancer. Therefore, we hypothesized the chemopreventive effects of an ethanol extract of A. glehni (AG) on azoxymethane/dextran sulfate sodium (AOM/DSS)-induced colitis-associated cancer (CAC) in mice. In this study, we found that treatment with AG significantly attenuated the AOM/DSS-induced enlargement of the spleen and shortening of the colon. In addition, colonic tumor formation, colonic damage, and increased muscle thickness were significantly reduced in AOM/DSS-induced mice fed AG. Treatment with AG also reduced intestinal interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α production and decreased inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 protein expression in mice with AOM/DSS-induced CAC. Furthermore, AG reduced nuclear factor (NF)-κB activation via phosphorylation and degradation of inhibitor of kappa Bα (IκBα), leading to inhibition of NF-κB p65 nuclear translocation. It also downregulated the expression of NF-κB-related proteins, including the B-cell lymphoma 2 (Bcl-2) family and inhibitors of apoptosis proteins (IAPs), in mice with AOM/DSS-induced CAC. Taken together, these findings suggest that the treatment with AG inhibited colitis-associated colon carcinogenesis in mice, and this chemopreventive effect was strongly mediated by suppression of the NF-κB signaling pathway, indicating that AG could be a promising protective agent against CAC.

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Antiadipogenic Effects ofAster glehniExtract: In Vivo and In Vitro Effects

Cited by 30 publications

References 32 publications

Quercetin-rich onion peel extract suppresses adipogenesis by down-regulating adipogenic transcription factors and gene expression in 3T3-L1 adipocytes

Quercetin-rich onion peel extract suppresses adipogenesis by down-regulating adipogenic transcription factors and gene expression in 3T3-L1 adipocytes

High-Fat Diet Propelled AOM/DSS-Induced Colitis-Associated Colon Cancer Alleviated by Administration of Aster glehni via STAT3 Signaling Pathway

Chemopreventive Effect of Aster glehni on Inflammation-Induced Colorectal Carcinogenesis in Mice

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