Antiadhesive zwitterionic poly-(sulphobetaine methacrylate) brush coating functionalized with triclosan for high-efficiency antibacterial performance

Tang, Zhao-Wen; Ma, Chaoyang; Wu, Haixia; Tan, Lei; Xiao, Jian-Yun; Zhuo, Ren‐Xi; Liu, Chuan-Jun

doi:10.1016/j.porgcoat.2016.04.038

Cited by 36 publications

(29 citation statements)

References 58 publications

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“…Active components, which are either leaching or covalently attached, kill adherent and/or planktonic bacteria and thereby slow surface colonization by these organisms. Materials that significantly slow protein adhesion and are at the same time strongly antimicrobially active are rare and often complicated to fabricate. ,,,,,− …”

Section: Introductionmentioning

confidence: 99%

Simultaneously Antimicrobial, Protein-Repellent, and Cell-Compatible Polyzwitterion Networks: More Insight on Bioactivity and Physical Properties

Kurowska¹,

Eickenscheidt²,

Al‐Ahmad

et al. 2018

ACS Appl. Bio Mater.

102

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A poly(oxanorbornene)-based polyzwitterion with primary ammonium and carboxylate groups (PZI) has been reported previously as the first simultaneously antimicrobial and protein-repellent polyzwitterion. Here, additional physical and biological properties of three poly(oxanorbornene)-based polyzwitterions with different functional groups (PZI, the polycarboxybetaine (PCB), and the polysulfobetaine (PSB)) are compared to understand the molecular origins of this unusual bioactivity. Additionally, the three polyzwitterions and the antimicrobial polycationic SMAMP are exposed to proteins, bacteria suspensions, human plasma, and serum. These interactions are investigated by surface plasmon resonance spectroscopy. In protein adhesion studies, neither fibrinogen nor lysozyme adhere irreversibly to PZI, yet reversible interaction with lysozyme is observed at pH 7 and 8. In the presence of bivalent cations, reversible fibrinogen adhesion is observed on PZI and PSB but not on PCB. This might explain why mammalian cells grow on PZI and PSB but not on PCB. PZI does not show human plasma adhesion, whereas PCB and PSB have 0.27 and 0.48 ng mm–2 adhered plasma and SMAMP even at 6.3 ng mm–2. Both PZI and SMAMP show strong serum adhesion, whereas no serum adhered to PCB and only a little adhered to PSB. This could be related to the pH difference between serum and plasma to which the pH-responsive primary ammonium groups are susceptible while the permanently charged NR4 + groups are unaffected. Both PZI and PCB showed no or only a little bacterial adhesion. PCB is also intrinsically antimicrobial against E. coli and S. aureus bacteria and thus is also simultaneously protein-repellent and antimicrobially active. Thus, although the carboxylate groups of PZI and PCB seem to be a prerequisite for the dual antimicrobial activity and protein-repellency, the pH responsiveness of the primary ammonium group seems to make the PZI molecule vulnerable for protein adhesion in fluids that are slightly out of the physiological range.

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Section: Introductionmentioning

confidence: 99%

Simultaneously Antimicrobial, Protein-Repellent, and Cell-Compatible Polyzwitterion Networks: More Insight on Bioactivity and Physical Properties

Kurowska¹,

Eickenscheidt²,

Al‐Ahmad

et al. 2018

ACS Appl. Bio Mater.

102

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“…On the basis of this phenomenon, many studies have proposed immobilizing the surface with nonfouling hydrophilic materials including poly(ethylene glycol) (PEG) and zwitterionic polymers (carboxybetaine, phosphobetaine, and sulfobetaine) on different substrates to increase resistance to cell adhesion. 17,18 The antiadhesion properties of PEG are attributed to the ability of PEG to form a hydration layer through hydrogen bonding with water molecules, which gives rise to repulsive forces and subsequent resistance to bacterial adhesion (Figure 2b). 17,19 Zwitterionic materials, having both positively and negatively charged functional groups, have received increased attention in recent years due to their ability to strongly bind with water molecules through electrostatically induced hydration (Figure 2a).…”

Section: Single-function Bioresponsive Materialsmentioning

confidence: 99%

“…This hydration layer ultimately helps prevent or reduce bacterial adhesion. On the basis of this phenomenon, many studies have proposed immobilizing the surface with nonfouling hydrophilic materials including poly(ethylene glycol) (PEG) and zwitterionic polymers (carboxybetaine, phosphobetaine, and sulfobetaine) on different substrates to increase resistance to cell adhesion. , The antiadhesion properties of PEG are attributed to the ability of PEG to form a hydration layer through hydrogen bonding with water molecules, which gives rise to repulsive forces and subsequent resistance to bacterial adhesion (Figure b). , Zwitterionic materials, having both positively and negatively charged functional groups, have received increased attention in recent years due to their ability to strongly bind with water molecules through electrostatically induced hydration (Figure a). Zwitterionic materials can bind water more strongly than PEG-based materials, and they are promising candidates in the design of surfaces that resist the attachment of bacterial cells. , Another defensive strategy is creating or inducing surface charge to tune the interaction between the desired material and bacterial cells.…”

Section: Single-function Bioresponsive Materialsmentioning

confidence: 99%

Switchable Dual-Function and Bioresponsive Materials to Control Bacterial Infections

Ghasemlou¹,

Daver²,

Ivanova

et al. 2019

ACS Appl. Mater. Interfaces

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The colonization of undesired bacteria on the surface of devices used in biomedical and clinical applications has become a persistent problem. Different types of single-function (cell resistance or bactericidal) bioresponsive materials have been developed to cope with this problem. Even though these materials meet the basic requirements of many biomedical and clinical applications, dual-function (cell resistance and biocidal) bioresponsive materials with superior design and function could be better suited for these applications. The past few years have witnessed the emergence of a new class of dual-function materials that can reversibly switch between cell-resistance and biocidal functions in response to external stimuli. These materials are finding increased applications in biomedical devices, tissue engineering, and drug-delivery systems. This review highlights the recent advances in design, structure, and fabrication of dualfunction bioresponsive materials and discusses translational challenges and future prospects for research involving these materials.

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“…A zwitterionic polyelectrolyte is a well-known compound that contains both a cation group and an anion group on the same side chain of a polymer. 28 zwitterionic polyelectrolyte tends to trap water molecules firmly and form a stable hydration layer around the charged moieties, which can effectively repel foulants such as protein, 29−31 bacteria, 32,33 and oil droplets. 34−37 In this study, we develop a zwitterionic nanohydrogel-grafted PVDF (ZNG-g-PVDF) nanofibrous membrane for removing crude oil from oil-in-water emulsions with high efficiency.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Because of charge balance, it always presents charge neutrality overall. Meanwhile, a zwitterionic polyelectrolyte tends to trap water molecules firmly and form a stable hydration layer around the charged moieties, which can effectively repel foulants such as protein, − bacteria, , and oil droplets. − In this study, we develop a zwitterionic nanohydrogel-grafted PVDF (ZNG- g -PVDF) nanofibrous membrane for removing crude oil from oil-in-water emulsions with high efficiency. As we know, electrospinning is a very important method for preparing highly porous nanofibrous membranes with an interconnected pore structure and a relatively uniform pore size. − By tailoring the electrospinning parameters and solution components, a ZNG- g -PVDF nanofibrous membrane with specific microspheres and a nanofiber interpenetrated structure is obtained. ,− The microspheres and nanofiber interpenetrated structure endow the electrospun membrane with a rough surface and high porosity.…”

Section: Introductionmentioning

confidence: 99%

Zwitterionic Nanofibrous Membranes with a Superior Antifouling Property for Gravity-Driven Crude Oil-in-Water Emulsion Separation

et al. 2018

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The development of membranes with a superior antifouling property and high-permeation flux is extensively considered but still a challenge for handling emulsified oil foulants in wastewater. Herein, a zwitterionic nanohydrogelgrafted PVDF (ZNG-g-PVDF) nanofibrous membrane was fabricated via a simple surface activation and amide reaction. By tailoring the parameters for electrospinning, PAA-g-PVDF nanofibrous membranes with interpenetrated nanofibers and microsphere structure were formed, and the membrane surface was endowed with high roughness on the micrometer scale. Combined with the strong hydration ability of the grafted zwitterionic nanohydrogels, the obtained ZNG-g-PVDF nanofibrous membrane exhibited a superhydrophilic property and nearly zero adhesion to crude oil under water. It thus showed an extremely high removal efficiency (∼98.7%) for gravity-driven separation of the crude oil-in-water emulsion. Both the water-permeating flux and oil content in the collected filtrate (lower than 13 ppm) showed little change during 10 cycles of the filtration experiment, indicating superior crude oil foulant repellency performance of the ZNG-g-PVDF nanofibrous membrane. Considering the high energy saving of the gravity-driven separation process, this novel ZNG-g-PVDF nanofibrous membrane possesses broad applications in the field of emulsified crude oil foulant cleanup in an aquatic environment.

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Antiadhesive zwitterionic poly-(sulphobetaine methacrylate) brush coating functionalized with triclosan for high-efficiency antibacterial performance

Cited by 36 publications

References 58 publications

Simultaneously Antimicrobial, Protein-Repellent, and Cell-Compatible Polyzwitterion Networks: More Insight on Bioactivity and Physical Properties

Simultaneously Antimicrobial, Protein-Repellent, and Cell-Compatible Polyzwitterion Networks: More Insight on Bioactivity and Physical Properties

Switchable Dual-Function and Bioresponsive Materials to Control Bacterial Infections

Zwitterionic Nanofibrous Membranes with a Superior Antifouling Property for Gravity-Driven Crude Oil-in-Water Emulsion Separation

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