Antiadhesive Properties of Abelmoschus esculentus (Okra) Immature Fruit Extract against Helicobacter pylori Adhesion

Messing, Jutta; Thöle, Christian; Niehues, Michael; Shevtsova, Anna; Glocker, Erik; Borén, Thomas; Hensel, Andreas

doi:10.1371/journal.pone.0084836

Cited by 70 publications

(79 citation statements)

References 35 publications

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“…Okra's polysaccharides were particularly effective at inhibiting the adhesion of Helicobacter pylori, a bacterium that dwells in the stomach and can cause gastritis and gastric ulcers if left unchecked. Therefore, eating more okra can keep our stomach clean and create an environment that prevents destructive cultures from flourishing (Messing et al, 2014). Okra is used to supports colon health.…”

Section: Health Benefits Of Okramentioning

confidence: 99%

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Nutritional Quality and Health Benefits of Okra (Abelmoschus esculentus): A Review

Gemede¹,

Ratta²,

Haki³

et al. 2015

J Food Process Technol

185

158

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Okra (Abelmoschus esculentus) is an economically important vegetable crop grown in tropical and sub-tropical parts of the world. This paper was aimed to review nutritional quality and potential health benefits of edible parts of Okra. Okra is a multipurpose crop due to its various uses of the fresh leaves, buds, flowers, pods, stems and seeds. Okra immature fruits, which are consumed as vegetables, can be used in salads, soups and stews, fresh or dried, fried or boiled. It offers mucilaginous consistency after cooking. Often the extract obtained from the fruit is added to different recipes like stews and sauces to increase the consistency. Okra mucilage has medicinal applications when used as a plasma replacement or blood volume expander. The mucilage of okra binds cholesterol and bile acid carrying toxins dumped into it by the liver. Okra seeds are a potential source of oil, with concentrations varying from 20% to 40%, which consists of linoleic acid up to 47.4%. Okra seed oil is also a rich source of linoleic acid, a polyunsaturated fatty acid essential for human nutrition. Okra has been called "a perfect villager's vegetable" because of its robust nature, dietary fiber, and distinct seed protein balance of both lysine and tryptophan amino acids. The amino acid composition of okra seed protein is comparable to that of soybean and the protein efficiency ratio is higher than that of soybean and the amino acid pattern of the protein renders it an adequate supplement to legume or cereal based diets. Okra seed is known to be rich in high quality protein especially with regards to its content of essential amino acids relative to other plant protein sources. Okra is a powerhouse of valuable nutrients, nearly half of which is soluble fibre in the form of gums and pectins which help to lower serum cholesterol, reducing the risk of heart diseases. The other fraction of Okra is insoluble fibre, which helps to keep the intestinal tract healthy. Okra is also abundant with several carbohydrates, minerals and vitamins, which plays a vital role in human diet and health. Okra is rich in phenolic compounds with important biological properties like quartering and flavonol derivatives, catechin oligomers and hydroxycinnamic derivatives. Okra is also known for being high in antioxidants activity. Okra has several potential health beneficial effects on some of the important human diseases like cardiovascular disease, type 2 diabetes, digestive diseases and some cancers. Overall, Okra is an important vegetable crop with a diverse array of nutritional quality and potential health benefits.

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Section: Health Benefits Of Okramentioning

confidence: 99%

“…Okra is better ingested when joined along with other healthy veggies. Consuming okra has truly numerous advantages, simply bear in mind to eat natural veggies as opposed to processed veggies (Messing et al, 2014). Okra is used to controls the body's cholesterol level.…”

Section: Health Benefits Of Okramentioning

confidence: 99%

Nutritional Quality and Health Benefits of Okra (Abelmoschus esculentus): A Review

Gemede¹,

Ratta²,

Haki³

et al. 2015

J Food Process Technol

185

158

View full text Add to dashboard Cite

show abstract

“…"Okra"'s polysaccharides were particularly effective at inhibiting the adhesion of Helicobacter pylori, a bacterium that dwells in the stomach and can cause gastritis and gastric ulcers if left unchecked. Therefore, eating more "Okra" can keep our stomach clean and create an environment that prevents destructive cultures from flourishing [77]. "Okra" is used to supports colon health.…”

Section: Health Benefits Of "Okra"mentioning

confidence: 99%

“…"Okra" is better ingested when joined along with other healthy veggies. Consuming "Okra" has truly numerous advantages, simply bear in mind to eat natural veggies as opposed to processed veggies [77].…”

Section: Health Benefits Of "Okra"mentioning

confidence: 99%

Nutritional Quality and Health Benefits of “Okra” (Abelmoschus esculentus): A Review

Gemede¹

2015

IJNFS

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“…This plant has been used to treat various disorders, amongst which inflammatory conditions [13,14]. Some recent studies have demonstrated antinociceptive and anti-inflammatory activity of the A. esculentus lectin (AEL) [15].…”

Section: Introductionmentioning

confidence: 99%

Lectin from Abelmoschus esculentus reduces zymosan-induced temporomandibular joint inflammatory hypernociception in rats via heme oxygenase-1 pathway integrity and tnf-α and il-1β suppression

Freitas

Val

Fernandes

et al. 2016

International Immunopharmacology

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Temporomandibular joint (TMJ) disorders show inflammatory components, heavily impacting on quality of life. Abelmoschus esculentus is largely cultivated in Northeastern Brazil for medicinal purposes, having it shown anti-inflammatory activity. We evaluated A. esculentus lectin (AEL) efficacy in reducing zymosan-induced temporomandibular joint inflammatory hypernociception in rats along with the mechanism of action through which it exerts anti-inflammatory activity. Animals were pre-treated with AEL (0.01, 0.1 or 1mg/kg) before zymosan (Zy) injection in the TMJ to determine anti-inflammatory activity. To analyse the possible effect of the hemeoxygenase-1 (HO-1) and the nitric oxide (NO) pathways on AEL efficacy, animals were pre-treated with ZnPP-IX (3mg/kg), a specific HO-1 inhibitor, or aminoguanidine (30mg/kg), a selective iNOS inhibitor, before AEL administration. Von Frey test evaluated inflammatory hypernociception, synovial fluid collection was performed to determine leukocyte counting and myeloperoxidase (MPO) activity 6h after Zy injection, and Evans Blue extravasation determined vascular permeability. TMJ tissue was collected for histopathological analysis (H&E) and immunohistochemistry (TNF-α, IL-1β, HO-1). In addition, TMJ tissue and trigeminal ganglion collection was performed for TNF-α and IL-1β dosage (ELISA). AEL increased inflammatory nociceptive threshold, reduced leukocyte influx along with MPO activity, leukocyte influx into the synovial membrane, and Evans Blue extravasation. It promoted HO-1 overexpression whilst decreased TNF-α and IL-1β expression in the TMJ tissue. AEL reduced TNF-α and IL-1β levels in TMJ tissue and trigeminal ganglion. AEL effects, however, were not observed in the presence of ZnPP-IX. These findings suggest that AEL efficacy depends on TNF-α/IL-1β inhibition and HO-1 pathway integrity.

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Antiadhesive Properties of Abelmoschus esculentus (Okra) Immature Fruit Extract against Helicobacter pylori Adhesion

Cited by 70 publications

References 35 publications

Nutritional Quality and Health Benefits of Okra (Abelmoschus esculentus): A Review

Nutritional Quality and Health Benefits of Okra (Abelmoschus esculentus): A Review

Nutritional Quality and Health Benefits of “Okra” (Abelmoschus esculentus): A Review

Lectin from Abelmoschus esculentus reduces zymosan-induced temporomandibular joint inflammatory hypernociception in rats via heme oxygenase-1 pathway integrity and tnf-α and il-1β suppression

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