Anti-ulcer potential of Haldinia cordifolia

Kasinadhuni, V.R.R; Rajashekhar, G.; Rajagopalan, Rukkumani; Sharma, Vikash; Krishna, Ch Vamsi Anil; Sairam, P; Prasad, G.; Sadhukhan, Sushabhan; Rao, Ganga

doi:10.1016/s0367-326x(98)00043-4

Cited by 21 publications

(10 citation statements)

References 7 publications

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“…1). The structures of these compounds were elucidated by spectroscopic methods (IR, 1 H NMR, 13 C NMR, DEPT and ESI-MS) and compared with the literature data [18,21].…”

Section: Resultsmentioning

confidence: 99%

“…The roots are used as an astringent in dysentery [17]. The A. cordifolia stem has been evaluated for its antiulcer potential and enzyme assay-guided fractionation of the chloroform extract yielded 7-hydroxycoumarin which showed interesting H þ /K þ ATPase inhibitory activity [18]. Antifertility properties of the leaf extract of A. cordifolia have been also examined [19].…”

Section: Introductionmentioning

confidence: 99%

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Antiamoebic coumarins from the root bark of Adina cordifolia and their new thiosemicarbazone derivatives

Iqbal

Bhat

Azam

2009

European Journal of Medicinal Chemistry

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“…1). The structures of these compounds were elucidated by spectroscopic methods (IR, 1 H NMR, 13 C NMR, DEPT and ESI-MS) and compared with the literature data [18,21].…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antiamoebic coumarins from the root bark of Adina cordifolia and their new thiosemicarbazone derivatives

Iqbal

Bhat

Azam

2009

European Journal of Medicinal Chemistry

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“…Em estudos realizados com caules de S. versicolor foram isoladas cumarinas (Simote 2006). Embora as cumarinas sejam capazes de provocar quadros hemorrágicos em diferentes espécies (McGavin & Zachary 2009) e em alguns trabalhos serem descritas por possuírem efeito citostático (Kasinadhuni et al 1999) e imunossupressor (Houl & Payá 1996), nas intoxicações espontâneas e experimentais não há relatos de lesões gastrointestinais e em tecido linfoide. Isto sugere que Simarouba versicolor pode ter mais de um princípio tóxico ou que há um princípio responsável pelas lesões ainda não isolado.…”

Section: Discussionunclassified

Intoxicação experimental por Simarouba versicolor (Simaroubaceae) em ovinos e indução de resistência ao consumo da planta

et al. 2013

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Hil. is a semideciduous tree belonging to the Simaroubaceae family. An outbreak of poisoning in cattle by shoots of S. versicolor present in the pasture in Mato Grosso do Sul and experimental reproduction of the poisoning was described. This study aimed to verify experimentally whether sheep could be used as a clinical-pathological model in the study of the poisoning caused by S. versicolor, to determine if there develops resistance induced by ingestion of small and repeated doses of the leaves, and if the plant keeps its toxicity when dried. Two experiments were conducted: Experiment 1 with green leaves or dried and powdered leave of S. versicolor, given in single doses of 5g/kg, 5g/kg and 3g/kg to three sheep (Sheep 1, 2 and 3 respectively). Experiment 2 was made with different daily doses of dried and powdered leaves of S. versicolor; to four sheep was given 1.5g/ kg, 0.75g/kg, 0.6g/kg and 0.3g/kg, and the positive control (Sheep 4) received 3g/kg. The administration was suspended when the animals showed clinical signs of poisoning. After twelve days of recovery, the surviving sheep were challenged with the same daily dose given previously, to assess the development of resistance. Clinical signs observed in both experiments were characterized by anorexia, congested ocular mucosa, polydipsia, drooling, loose stools which evolved into fetid greenish watery diarrhea, lateral decumbency and death of Sheep 1 to 7. The main histological lesions observed were necrosis of lymphoid tissue (lymph nodes, spleen, Peyer's patches) and necrotizing enteritis. With the results it can be concluded that sheep can be used as experimental model for the clinic-pathological aspects of poisoning by S. versicolor. The method used has not shown resistance to the daily consumption of the plant by the sheep, and the leaves kept their toxicity when dried.INDEX TERMS.-Poisonous plants, Simarouba versicolor, Simaroubaceae, lymphoid necrosis, necrotizing enteritis, plant poisoning, sheep.

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“…Coumarin and its derivatives have a wide spectrum of bioactivities including anticoagulant, estrogenic, dermal photosensitizing, vasodilator, molluscacidal, anthelmintic, sedative, hypnotic, analgesic, hypothermic [6], antimicrobial [7], anti-inflammatory [8], antifungal [9] and antiulcer [10] activities. In vitro, coumarin and its derivatives inhibit the proliferation of several human tumor cell lines, viz., coumarin 0022-328X/$ -see front matter Ó 2004 Elsevier B.V. All rights reserved.…”

Section: Introductionmentioning

confidence: 99%

Triorganotin(IV) derivatives of umbelliferone (7-hydroxycoumarin) and their adducts with 1,10-phenanthroline: synthesis, structural and biological studies

Nath¹,

Jairath²,

Eng³

et al. 2005

Journal of Organometallic Chemistry

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Anti-ulcer potential of Haldinia cordifolia

Cited by 21 publications

References 7 publications

Antiamoebic coumarins from the root bark of Adina cordifolia and their new thiosemicarbazone derivatives

Antiamoebic coumarins from the root bark of Adina cordifolia and their new thiosemicarbazone derivatives

Intoxicação experimental por Simarouba versicolor (Simaroubaceae) em ovinos e indução de resistência ao consumo da planta

Triorganotin(IV) derivatives of umbelliferone (7-hydroxycoumarin) and their adducts with 1,10-phenanthroline: synthesis, structural and biological studies

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