Anti-ulcer, anti-inflammatory and antioxidant activities of the n-butanol fraction from Pteleopsis suberosa stem bark

Germanò, Maria Paola; D’Angelo, Valeria; Biasini, T.; Miano, T.C.; Braca, Alessandra; Leo, Marinella De; Pasquale, R. De; Sanogo, Rokia

doi:10.1016/j.jep.2007.10.001

Cited by 19 publications

(10 citation statements)

References 21 publications

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“…In the study, the extract exhibited appreciable scavenging ability against DPPH (IC 50 ¼ 51.27 mg/ml) and NO radicals (IC 50 ¼ 61.42 mg/ml). As ROS play an important role in mediating chronic inflammation (Reuter et al, 2010), the free radical scavenging capability of the extract might be considered as one possible mechanism of action underlying the anti-inflammatory effect seen here and by others (Dordevic et al, 2007;Germano et al, 2008). Among the known constituents in the extract, alkaloids and flavonoids are known to possess free radical scavenging activities.…”

Section: Discussionmentioning

confidence: 67%

Acacia ferrugineainhibits inflammation by regulating inflammatory iNOS and COX-2

Sakthivel

Guruvayoorappan

2015

Journal of Immunotoxicology

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Inflammation is a local defensive reaction of a host to cellular injury or infection. Prolonged inflammation can contribute to pathogenesis of many disorders. Identification of naturally occurring phytoconstituents that can suppress inflammatory mediators can lead to the discovery of anti-inflammatory therapeutics. Acacia ferruginea is used traditionally to treat numerous ailments including hemorrhage, irritable bowel syndrome and leprosy. The present study evaluated the anti-inflammatory activity of A. ferruginea extract against acute (carrageenan) and chronic (formaldehyde) inflammation in Balb/c mice. Pre-treatment with A. ferruginea extract (10 mg/kg BW) for 5 consecutive days via intraperitonial (IP) administration significantly inhibited subsequent induction of paw edema in both models; the effects were comparable to that of the standard drug indomethacin. The results also showed the A. ferruginea extract significantly inhibited nitric oxide (NO) synthesis and iNOS expression (as measured in serum), diminished inflammation in -and neutrophil infiltration to -the paw tissues and led to a reduction in the number of COX-2 + immunoreative cells (as evidenced by histologic and immunohistochemical analyses) in the paws relative to those in paws of mice that received the irritants only. Further, in vitro studies showed the extract could significantly scavenge free radicals generated as in DPPH and NO radical generating assays. Taken together, the results showed that A. ferruginea extract imparted potent anti-oxidant and -inflammatory effects, in part by maintaining oxidative homeostasis, inhibiting NO synthesis and suppressing iNOS and COX-2 expression and so could potentially be exploited as a potential plant-based medication against inflammatory disorders.

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Section: Discussionmentioning

confidence: 67%

Acacia ferrugineainhibits inflammation by regulating inflammatory iNOS and COX-2

Sakthivel

Guruvayoorappan

2015

Journal of Immunotoxicology

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“…The animals were sacrificed by cervical dislocation after 1 h of alcohol induction. The stomach was taken out and cut open along the greater curvature, length of lesion was measured and summed of the length of damage under anatomical microscopic (Xu et al, 2002;Germanò et al, 2008).…”

Section: Ethanol-induced Gastric Ulcersmentioning

confidence: 99%

The anti-ulcer activities of bisabolangelone from Angelica polymorpha

Wang

Zhu

Zou

et al. 2009

Journal of Ethnopharmacology

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“…Les autres détails de nos différents protocoles sont mentionnés dans les publications respectives [6][7][8][9].…”

Section: Evaluation De L'activité Antimicrobienneunclassified

“…Des études récentes ont permis de confirmer davantage les propriétés gastroprotectrices de la fraction butanolique de l'extrait méthanolique de l'écorce de tronc de P. suberosa [7]. En outre, la même fraction a présenté des propriétés anti-inflammatoires et antioxydantes [8]. …”

Section: Résultatsunclassified

Pteolopsis suberosa Engl. et Diels (Combretaceae) : une plante à activité antiulcère et anti Helicobacter pylori

Sanogo¹

2014

Hegel

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Anti-ulcer, anti-inflammatory and antioxidant activities of the n-butanol fraction from Pteleopsis suberosa stem bark

Cited by 19 publications

References 21 publications

Acacia ferrugineainhibits inflammation by regulating inflammatory iNOS and COX-2

Acacia ferrugineainhibits inflammation by regulating inflammatory iNOS and COX-2

The anti-ulcer activities of bisabolangelone from Angelica polymorpha

Pteolopsis suberosa Engl. et Diels (Combretaceae) : une plante à activité antiulcère et anti Helicobacter pylori

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