Anti-ulcer activity of NS-EA 51 – A fraction of Nigella sativa seed, in histamine plus pylorus-ligated and hypothermia plus restrain stressed rat models

Zaman, Rifat uz; Akhtar, Muhammad Shoaib; Khan, Muhammad Shuaib

doi:10.1016/j.jopr.2012.11.007

Cited by 3 publications

(1 citation statement)

References 19 publications

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“…From the pharmacological aspect, thymoquinone is the most active component found plentifully (30% to 48%) in the Nigella sativa seeds in addition to its derivatives such as thymol, thymohydroquinone, and dithymoquinone (17). Numerous animal experiments in which the gastric mucosal injury was induced by pyloric ligation (18), ethanol (19), ischemia-reperfusion (20), and stress (18) have been indicated that the acute usage of Nigella sativa oil and its integral ingredient thymoquinone exert gastroprotective properties.…”

Section: Introductionmentioning

confidence: 99%

The preventive effect of Nigella sativa seed on gastric ulcer induced by indomethacin in rat

Paseban

Niazmand

Soukhtanloo

et al. 2020

J Herbmed Pharmacol

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Introduction: Nonsteroidal anti-inflammatory drugs (NSAIDs) are considered as one of the most administrated groups of medications worldwide. Due to the role of NSAIDs in inducing gastric ulceration, their clinical applications are still challenging. Nigella sativa seed is widely used as an herbal medication against gastrointestinal complications. The present experiment was carried out to investigate the impact of N. sativa seed hydro-alcoholic extract on gastric ulcer induced by indomethacin (IND) and to evaluate its possible mechanisms in rat. Methods: This study was performed on 48 male Wistar rats. Acute gastric ulceration was induced by IND (35 mg/kg). N. sativa seed extract (100, 200, 400 mg/kg) and ranitidine (50 mg/kg) were administered orally for five days before the induction ulcer. Ulcer index, gastric acid secretion, gastric mucus content, glutathione (GSH), malondialdehyde (MDA), total hexose, gastric juice protein content were determined on the fifth day. Results: The ulcer index in all groups of N. sativa seed was significantly lower than that of the IND group. N sativa seed considerably decreased MDA and protein content, but increased total thiol, total hexose, and mucus content compared to the IND group. N. sativa seed did not affect gastric acid secretion. Conclusion: These findings were indicative of the gastroprotective effect of N. sativa seed against the IND-induced ulcer, suggesting that it can mainly be exerted through the anti-oxidant activity of the extract as well as its role in stimulating gastric mucus secretion and increasing total hexose in the gastric mucosa.

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Section: Introductionmentioning

confidence: 99%

The preventive effect of Nigella sativa seed on gastric ulcer induced by indomethacin in rat

Paseban

Niazmand

Soukhtanloo

et al. 2020

J Herbmed Pharmacol

View full text Add to dashboard Cite

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Bio-active nanoemulsions enriched with gold nanoparticle, marigold extracts and lipoic acid: In vitro investigations

Guler

Barlas

Yavuz

et al. 2014

Colloids and Surfaces B: Biointerfaces

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The Therapeutic Effect of Nigella sativa Seed on Indomethacin-induced Gastric Ulcer in Rats

Paseban

Niazmand

Soukhtanloo

et al. 2020

CNF

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Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used to relieve pain and reduce inflammation. However, gastric complications remain a major problem limiting their clinical usage. This study was carried out to evaluate the therapeutic effect of Nigella sativa seed (N. sativa seed) hydroalcoholic extract on indomethacin-induced gastric ulcer in rats and its possible mechanism. Methods: This study was carried out on forty-eight male Wistar rats. Gastric ulcer was induced by indomethacin (35 mg/kg). N. sativa seed extract (100, 200, and 400 mg/kg) and ranitidine (50 mg/kg) was administered orally for five days after ulcer induction. Ulcer index, gastric acid secretion, gastric mucus content, total thiol, malondialdehyde (MDA), and total hexose, and protein content in gastric juice were determined. Results: The ulcer index in groups of N. sativa seed was significantly lower as compared to indomethacin group. N. sativa seed significantly decreased MDA and protein content, but increased total thiol, total hexose, and mucus content as compared to indomethacin group. N. sativa seed did not affect gastric acid secretion. Conclusion: These findings showed that the gastroprotective effect of N. sativa seed against indomethacin- induced ulcer was mainly exerted by antioxidant activity, stimulation of gastric mucus secretion and also increased total hexose in the gastric mucosa.

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Anti-ulcer activity of NS-EA 51 – A fraction of Nigella sativa seed, in histamine plus pylorus-ligated and hypothermia plus restrain stressed rat models

Cited by 3 publications

References 19 publications

The preventive effect of Nigella sativa seed on gastric ulcer induced by indomethacin in rat

The preventive effect of Nigella sativa seed on gastric ulcer induced by indomethacin in rat

Bio-active nanoemulsions enriched with gold nanoparticle, marigold extracts and lipoic acid: In vitro investigations

The Therapeutic Effect of Nigella sativa Seed on Indomethacin-induced Gastric Ulcer in Rats

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