Anti-tumour necrosis factor   therapy modulates ghrelin in patients with severe rheumatoid arthritis

Role of the TNF pathway in the progression of diabetic nephropathy in KK-Aymice

“…In this regard, Lacerda et al (30) demonstrated that TNF knockout mice with streptozotocin-induced diabetes have a favorable effect on glycemic control. Furthermore, glycemic control improved after the administration of ETN in rheumatoid arthritis patients with concomitant diabetes (22). Thus, we cannot exclude the possibility that ETN might have ameliorated nephropathy through the improvement of glycemic control, although ETN did not alter adiponectin levels.…”

Serum adipokine levels in rheumatoid arthritis patients and their contributions to the resistance to treatment

“…Furthermore, visfatin was not associated with inflammation in patients with severe RA undergoing anti-TNF-α therapy (20). Another study reported that anti-TNF-α therapy resulted in a rapid reduction in serum resistin levels, but did not modulate leptin levels in RA patients (21). It was also demonstrated that serum leptin concentrations are inversely correlated with inflammation in RA (22).…”

The role of resistin as a regulator of inflammation: Implications for various human pathologies

“…Very recently, a decline in serum levels of resistin after TNF-α blocking therapy has been shown; it is evident that this therapy, in addition to reducing joint inflammation, can concomitantly improve the cardiovascular prognosis in inflammatory disorders [108,109]. An association between serum resistin levels, inflammation, bone mineral density, and renal functions has been demonstrated in patients with systemic lupus erythematosus (SLE) [110].…”

“…Resistin significantly decreased after the TNF-α blocking therapy in patients with rheumatoid arthritis and inflammatory bowel disease [108,109,123]. Treatment of patients with the skin form of psoriasis with retinoids leads to a normalization of serum resistin levels [113].…”