Serum adipokine levels in rheumatoid arthritis patients and their contributions to the resistance to treatment

Kim, Kyoung Soo; Choi, Hyun Rim; Ji, Hye-In; Song, Ran; Yang, Haesik; Lee, Soo Kon; Yoo, Myung Chul; Park, Yong Bum

doi:10.3892/mmr.2013.1764

Cited by 21 publications

(22 citation statements)

References 23 publications

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“…A study of the 6-month response in patients with RA similarly failed to find an association between NAMPT levels and disease activity, and failed to observe a change in NAMPT levels over the study period. 33 Similarly, a study in patients with severe RA treated with infliximab found that NAMPT levels were not associated with disease activity and did not change in response to therapy. 34 The failure to observe any significant reduction in NAMPT over the study period does not necessarily lessen the importance of NAMPT in the pathogenesis of JIA, as MTX therapy may target the disease process downstream of NAMPT.…”

Section: Discussionmentioning

confidence: 98%

“…Although these findings contradict many of the studies in RA, these findings are not unprecedented. A study of the 6‐month response in patients with RA similarly failed to find an association between NAMPT levels and disease activity, and failed to observe a change in NAMPT levels over the study period . Similarly, a study in patients with severe RA treated with infliximab found that NAMPT levels were not associated with disease activity and did not change in response to therapy .…”

Section: Discussionmentioning

confidence: 99%

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Nicotinamide Phosphoribosyltransferase Attenuates Methotrexate Response in Juvenile Idiopathic Arthritis and In Vitro

Funk

Singh

Pramann

et al. 2016

Clinical Translational Sci

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Variability in response to methotrexate (MTX) in the treatment of Juvenile Idiopathic Arthritis (JIA) remains unpredictable and poorly understood. Based on previous studies implicating an interaction between nicotinamide phosphoribosyltransferase (NAMPT) expression and MTX therapy in inflammatory arthritis, we hypothesized that increased NAMPT expression would be associated with reduced therapeutic response to MTX in patients with JIA. A significant association was found between increased plasma concentrations of NAMPT and reduced therapeutic response in JIA patients treated with MTX. Inhibition of NAMPT in cell culture by either siRNA-based gene silencing or pharmacological inhibition with FK-866 was found to result in a 4-fold increase in the pharmacological activity of MTX. Collectively, these findings provide evidence that NAMPT inhibits the pharmacological activity of MTX and may represent a predictive biomarker of response, as well as a therapeutic target, in the treatment of JIA with MTX.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Nicotinamide Phosphoribosyltransferase Attenuates Methotrexate Response in Juvenile Idiopathic Arthritis and In Vitro

Funk

Singh

Pramann

et al. 2016

Clinical Translational Sci

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“…In previous studies, pharmacological treatments however affected the levels of adiponectin and resistin, although the reported effects were not consistent. For example, a reduction of adiponectin levels has been shown in RA patients after a combined corticoid and anti-TNF-α therapy (32), whereas in other studies an increase was observed (54). Hence, at present, the effects of pharmacological treatments on some adipokines remain elusive, possibly related to an impact of the disease stage or metabolic alterations.…”

Section: Discussionmentioning

confidence: 99%

Decrease of Markers Related to Bone Erosion in Serum of Patients with Musculoskeletal Disorders after Serial Low-Dose Radon Spa Therapy

et al. 2017

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Musculoskeletal disorders (MSDs) are the most frequent cause of disability in Europe. Reduced mobility and quality of life of the patients are often associated with pain due to chronic inflammation. The inflammatory process, accompanied by a destruction of the cartilage and bone tissue, is discussed as a result of (A) the infiltration of immune cells into the joints, (B) an altered homeostasis of the joint cavity (synovium) with a critical role of bone remodeling cells, and (C) release of inflammatory factors including adipokines in the arthritic joint. In addition to the classical medication, low-dose radiation therapy using photons or radon spa treatments has shown to reduce pain and improve the mobility of the patients. However, the cellular and molecular mechanisms of anti-inflammatory effects of radon are yet poorly understood. We analyzed blood and serum samples from 32 patients, suffering from MSDs, who had been treated in the radon spa in Bad Steben (Germany). Before and after therapy, we measured the levels of markers related to bone metabolism (collagen fragments type-1, cartilage oligomeric matrix protein, receptor activator of NFκB ligand, and osteoprotegerin) in the serum of patients. In addition, adipokines related to inflammation (visfatin, leptin, resistin, and adiponectin) were analyzed. Some of these factors are known to correlate with disease activity. Since T cells play an important role in the progression of the disease, we further analyzed in blood samples the frequency of pro- and anti-inflammatory T cell subpopulations (CD4+IL17+ T cells and CD4+FoxP3+ regulatory T cells). Overall, we found a decrease of collagen fragments (CTX-I), indicating decreased bone resorption, presumably by osteoclasts, in the serum of MSD patients. We also observed reduced levels of visfatin and a consistent trend toward an increase of regulatory T cells in the peripheral blood, both indicating attenuation of inflammation. However, key proteins of bone metabolism were unchanged on a systemic level, suggesting that these factors act locally after radon spa therapy of patients with MSDs.

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“…This adipokine can act as a regulator of inflammation and the destruction process of joints [35] and induce stimulation of great quantities of chemokines [50], thus possibly contributing to the inflammatory state of RA. However, its association to disease activity is not yet fully known [51].…”

Section: Visfatinmentioning

confidence: 99%

Adipokines in rheumatoid arthritis

et al. 2018

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Rheumatoid arthritis affects millions of people worldwide and is considered a chronic multisystem disease whose causes are unknown. In general, the main objective of rheumatoid arthritis treatment is to improve the quality of life of patients by relieving pain, maintaining or improving functional capacity, preventing thus, disability. In recent years the role of adipokines in the pathogenesis of rheumatoid arthritis has been discussed but results are still conflicting. Although results from some studies have shown the implications of adipokines in the pathophysiology of autoimmune diseases, including rheumatoid arthritis, their role in the pathogenesis of disease progression is not clear. Thus, this review aimed to describe the association of key adipokines (leptin, resistin, visfatin and adiponectin) and rheumatoid arthritis, given the high prevalence of this disease and the important social impact caused by this chronic disabling disease.

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Serum adipokine levels in rheumatoid arthritis patients and their contributions to the resistance to treatment

Cited by 21 publications

References 23 publications

Nicotinamide Phosphoribosyltransferase Attenuates Methotrexate Response in Juvenile Idiopathic Arthritis and In Vitro

Nicotinamide Phosphoribosyltransferase Attenuates Methotrexate Response in Juvenile Idiopathic Arthritis and In Vitro

Decrease of Markers Related to Bone Erosion in Serum of Patients with Musculoskeletal Disorders after Serial Low-Dose Radon Spa Therapy

Adipokines in rheumatoid arthritis

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