Anti-tumorigenic effect of nano formulated peptide pACC1 by diminishing de novo lipogenisis in DMBA induced mammary carcinoma rat model

Kaliaperumal, Jagatheesh; Padarthi, Pavankumar; Elangovan, Namasivayam; Hari, Natarajan

doi:10.1016/j.biopha.2014.07.016

Cited by 2 publications

(1 citation statement)

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“…In the present study increased levels of phosphoglucoisomerase were observed in liver and kidney which may be due to the higher glycolytic rate in liver tissues and further leakage from the destruction of neoplastic tissues. Alteration in the activity of phosphoglucoisomerase might be expected to influence the proportion of glucose-6-phosphate metabolized via the glycolytic pathway (Kaliaperumal et al, 2014). Aldolase, another key enzyme in the glycolytic pathway is also Int.…”

Section: Discussionmentioning

confidence: 99%

Chemopreventive Effect of Acanthus ilicifolius Extract on Modulating Antioxidants, Lipid Peroxidation and Membrane Bound Enzymes in Diethyl Nitrosamine Induced Liver Carcinogenesis

Rajamanick¹,

Selvaraj²,

Satyavani³

et al. 2015

International J. of Cancer Research

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Acanthus ilicifolius (Acanthaceae) has received considerable attention due to its wide range of traditional usage in Indian system of medicine. The chemopreventive effect of ethanol extracts of Acanthus ilicifolius (AIEE) on N-nitrosodiethylamine (DEN, 200 mg kgG 1 )-induced experimental liver tumour was investigated in male Wistar rats. Experimental rats were orally treated with AIEE (400 mg kgG 1 b.wt.) for 1 week before the injection of diethyl nitrosamine and continued to be 14 weeks. The changes of lipid peroxidation, antioxidants and membrane bound enzymes were studied in AIEE treated experimental and control rats. The result indicates AIEE treatment effectively suppressed liver tumour induced with DEN as revealed by decrease in the levels of extend of alanine transaminase, aspartate transaminase, alkaline phosphatase, lipid peroxidase, glutathione peroxidase and glutathione-S-transferase with a concomitant increase in enzymatic antioxidant (superoxide dismutase and catalase) levels when compared to those in liver tumour bearing rats. The result of the study concludes significant chemopreventive effect of AIEE against DEN induced liver tumour.

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Section: Discussionmentioning

confidence: 99%

Chemopreventive Effect of Acanthus ilicifolius Extract on Modulating Antioxidants, Lipid Peroxidation and Membrane Bound Enzymes in Diethyl Nitrosamine Induced Liver Carcinogenesis

Rajamanick¹,

Selvaraj²,

Satyavani³

et al. 2015

International J. of Cancer Research

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Nanoformulation of Peptides for Pharmaceutical Applications: In Vitro and In Vivo Perspectives

Ram

Tang²,

Kiew³

et al. 2022

Applied Sciences

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Peptides are short sequences of proteins consisting of two or more amino acids that are linked by peptide bonds. Peptide-based designs and drug deliveries can offer several advantages, such as antioxidant, antimicrobial, antihypertensive activities, along with immunomodulatory and antithrombotic properties, with hormone or drug-like potential. Peptide-based therapeutic formulations are used as drug candidates for the treatment of various diseases. However, there are several concerns associated with the efficacy of peptides in pharmaceutical design and delivery, including rapid degradation, limited solubility, and poor permeability. The nanoformulation of peptides has been identified as a promising approach for improving the stability of peptides and providing metabolic stability and bioavailability. This article provides an overview of the advances in the development of peptides for drug design and formulation applications. It discusses various peptide nanoformulation approaches as well as recent developments in the in vitro and in vivo analyses of nanoformulated peptides for pharmaceutical applications.

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Anti-tumorigenic effect of nano formulated peptide pACC1 by diminishing de novo lipogenisis in DMBA induced mammary carcinoma rat model

Cited by 2 publications

References 35 publications

Chemopreventive Effect of Acanthus ilicifolius Extract on Modulating Antioxidants, Lipid Peroxidation and Membrane Bound Enzymes in Diethyl Nitrosamine Induced Liver Carcinogenesis

Chemopreventive Effect of Acanthus ilicifolius Extract on Modulating Antioxidants, Lipid Peroxidation and Membrane Bound Enzymes in Diethyl Nitrosamine Induced Liver Carcinogenesis

Nanoformulation of Peptides for Pharmaceutical Applications: In Vitro and In Vivo Perspectives

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