Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

Antitumour effect of polyoxomolybdates: induction of apoptotic cell death and autophagy in in vitro and in vivo models

“…It is thought that PM-17 is an active state of PM-8 at inside of the body or cells. PM-8 is reduced by electron transfer system in mitochondria, and becomes PM-17, which is a more cytotoxic agent (Yamase, 2005). Also we think that some of the antitumour activity of PM-8 is derived from reduced species such as PM-17.…”

“…This would inhibit ATP generation, and such a significant difference in toxicity between PM-8 and its reduced species would lead to a tumour-selective inhibition. This is based on the enhanced metabolism in tumour cells, since the high molecular weight of the reduced species (as a condensed species) would result in a longer stay in the tumour cells (Yamase, 2005).…”

Les polyoxométallates

“…Elles possèdent des proprié-tés intéressantes en catalyse chimique. De plus, plusieurs POM présentent des activités antivirales, antibiotiques et anti-cancéreuses [15,16]. Cependant, leur mécanisme d'action et leurs cibles cellulaires demeurent mal définis.…”

Enhancement Effect of Polyoxometalates on NGF-Induced Neurite-Outgrowth of PC12 Cells

“…Various biological effects of polyoxometalates have been studied on antitumor, antiviral, and antibacterial activities. 1) With regard to the antibacterial activity of polyoxometalates (mainly polyoxotungstates) with Keggin, lacunary Keggin, Wells-Dawson, double-Keggin and Keggin-sandwich structures enhanced the antibacterial activity of b-lactam antibiotics against methicillin-resistant and vancomycin-resistant Staphylococcus aureus. [2][3][4][5] In order to extend the bio-activity of polyoxometalates, we have investigated a feasibility of the polyoxometalates-induced nerve growth of pheochromocytoma PC12 cells.…”