Anti-tumor metastatic activity of β-glucan purified from mutated Saccharomyces cerevisiae

Yoon, Tae‐Jong; Kim, Tack Joong; Lee, Hwa; Shin, Kihyun; Yun, Yong Soo; Moon, Won Kook; Kim, Dong Woo; Lee, Kwang Ho

doi:10.1016/j.intimp.2007.10.005

Cited by 73 publications

(45 citation statements)

References 23 publications

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“…Statistical analysis of these variations was very significant (Table 2). the schedules used to be interrupted, which compromises treatment results [10][11][12][13][14][15][16][17][18][19][20] .…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, the combats to this type of tumor have the objective of making T-lymphocytes active and competent 16,17,19,20 . In this study, we observed that the total lymphocytes and their subclasses showed an increase in counts, which was more pronounced with TF use for 12 months, and even when counts fell in the first six months of treatment, these were recovered after 12 months.…”

Section: Resultsmentioning

confidence: 99%

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Use of transfer factor in immunosuppressed surgical patients

Garritano

Nubila

Couto

et al. 2017

Rev. Col. Bras. Cir.

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Objective : to evaluate the action of Transfer Factor on the immune response of patients with malignant neoplasm submitted to surgery, chemotherapy and radiotherapy. Method: we analyzed the variations of leukocytes, total lymphocytes, T-lymphocytes and CD4 counts in 60 patients submitted to immunostimulation with a single, daily dose of 0.5mg sublingual Transfer Factor, started simultaneously with chemotherapy and/or radiotherapy. Results: there were statistically significant increases in the counts of all cell lines studied, more pronounced after 12 months of use of the medication. Conclusion: the Transfer Factor restored immune response and showed no side effects.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Use of transfer factor in immunosuppressed surgical patients

Garritano

Nubila

Couto

et al. 2017

Rev. Col. Bras. Cir.

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“…Some studies have shown that β-glucan isolated from mushroom (Shen et al, 2007), seaweed (Vetvicka et al, 2007), or Saccharomyces cerevisiae (Li et al, 2007;Yoon et al, 2008) influences the cytotoxic activity of immune cells, but β-glucan is simply showing structure of polysaccharides and contains a variety of molecules. Thus, mushrooms might have their own β-glucan.…”

Section: Discussionmentioning

confidence: 99%

Immunomodulatory effect of mushrooms on cytotoxic activity and cytokine production of intestinal lamina propria leukocytes does not necessarily depend on β-glucan contents

et al. 2011

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We evaluated the effects of seven mushroom extracts (Grifola frondosa, Pholiota nameko, Panellus serotinus, Hypsizygus marmoreus, Pleurotus cornucopiae, Armillaria mellea, and Flammulina velutipes) on cytotoxic activity and cytokine production of lamina propria leukocytes (LPLs) isolated from rat small (S) and large (L) intestinal mucosa. Boiling water extracts from seven species of mushrooms showed no direct cytotoxicity against the YAC-1 target cells. However, prominent increases of cytotoxicity were observed in S-and L-LPLs co-cultured with P. serotinus extract. Cytokine production (TNFα, IFNγ, IL-12 p70, and IL-4) of S-and L-LPLs was stimulated in response to P. cornucopiae extract. Mushroom extracts contribute to target cell adhesion and/or cytokine production in the effector cells. The promotion of cytotoxic activity in S-and L-LPLs was not necessarily related to β-glucan content of the mushroom.

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“…[8][9][10][11][12][13][14][15][16][17][18][19][20] Pe li zon et al re por ted that be ta-glu can ad mi nis tra ti on en han ced fun gi ci dal ac ti vity on Para coc ci di o i des bra si li en sis in the mi ce mo del by pri ming sple en cells for high pro duc ti on of IL-12 and TNF-alp ha as well as in cre a sing NK cell ac tivity. 19 In a rat mo del of sep sis, the pro tec ti ve ef fect of be ta-glu can aga inst oxi da ti ve or gan in jury by dep res sing li pid pe ro xi da ti on was de mons tra ted.…”

Section: Methodsmentioning

confidence: 99%

“…[7][8][9] Se ve ral stu di es con duc ted in the past de ca de sho wed that be ta-glu can in hi bited tu mor de ve lop ment, ac ti va ted mac rop ha ges, indu ced pro duc ti on of cyto ki nes, in cre a sed he ma to po i e sis, exer ted ra di op ro tec ti ve ef fects, impro ved wo und he a ling by in du cing the mac rop hages' re le a se of wo und growth fac tors, in cre a sed sa li vary IgA con cen tra ti on, and en han ced de fen ce aga inst in fec ti ons. [10][11][12][13][14] Pre vi o us re se arc hes in di cated that be ta glu can was used as a pre ven ti ve agent in the tre at ment of bac te ri al in fec ti ons. [15][16][17] Stu di es, ho we ver, abo ut the pos sib le pro tec ti ve ef fect on fun gal in fec ti ons are li mi ted.…”

mentioning

confidence: 99%

Protective Effect of Beta Glucan on Pulmonary Aspergillosis Model in Neutropenic Rats

Hızel¹,

Kalkancı²,

Çağlar³

et al. 2010

Turkiye Klinikleri J Med Sci

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A AB BS S T TR RA AC CT T O Ob b j je ec c t ti i v ve e: : Pul mo nary as per gil lo sis is a se ri o us op por tu nis tic in fec ti on which might be fa tal in im mu no com pro mi sed pa ti ents. Im mu nity aga inst as per gil lo sis re qu i res the co or di na ted acti on of com po nents of the in na te and adap ti ve im mu ne systems. Be ta-glu can is one of the im muno mo du la tory agents which got much at ten ti on in re cent ye ars. It was used as a pre ven ti ve agent for the de ve lop ment of in fec ti ons. Ho we ver, in for ma ti on abo ut its the pos sib le pro tec ti ve ef fect on fun gal in fec ti ons are li mi ted. The aim of this study aimed to in ves ti ga te the pos sib le pro tec ti ve effects of be ta-glu can aga inst As per gil lus fu mi ga tus in fec ti on. M Ma a t te e r ri i a al l a an nd d M Me et t h ho od ds s: : We eva lu a ted oral be ta glu can ad mi nis tra ti on for its abi lity to en han ce re sis tan ce of the rats to ex pe ri men tally indu ced pul mo nary as per gil lo sis. Fifty-eight rats we re di vi ded in to thre e gro ups: Thirty fi ve rats were im mu no sup pres sed and in fec ted with As per gil lus fu mi ga tus (in fec ted gro up); 15 we re im mu no sup pres sed, in fec ted and tre a ted with oral be ta-glu can (be ta-glu can gro up); and eight were he althy con trols. Rats we re sac ri fi ced on the tenth day of the ex pe ri ment and tis su e spe ci mens we re cul tu red. Chi tin, ga lac to man nan an ti gen and glu can le vels we re detected. R Re e s su ul lt ts s: : Be ta-glucan en han ced the re sis tan ce aga inst As per gil lus in fec ti on. The sur vi val ra tes we re 62.9 % and 93.4% in the in fec ted and be ta-glu can gro ups, res pec ti vely (p< 0.05). Be ta glu can al so li mi ted the fun gal bur den. C Co on nc c l lu u s si i o on n: : Our re sults sug ges ted that As per gil lus in va si on did not de ve lop in be ta-glu can gro up in spi te of the oc cu ren ce of fun gal co lo ni za ti on in ne ut ro pe nic rats. Be ta-glu can was ab le to im pro ve the re sis tan ce aga inst A. fu mi ga tus in fec ti on. K Ke ey y W Wo or rd ds s: : As per gil lo sis; be ta-glu cans; cytop ro tec ti on; im mu no sup pres si on Ö ÖZ ZE ET T A Am ma aç ç: : Pul mo ner as per gil loz im mün yet mez lik li has ta lar da ölüm cül ola bi len cid di bir fır sat -çı en fek si yon dur. As per jil lo zi se kar şı ba ğı şık lık do ğuş tan ge len ve adap tif im mün sis tem le rin bi leşen le ri nin bir lik te ha re ket et me si ni ge rek ti rir. Be ta-glu kan son yıl lar da çok dik kat çe ken im mü no mo dü la tör ajan lar dan bi ri dir. En fek si yon ge li şi min de ko ru yu cu ajan ola rak kul la nıl mış tır. Fa kat man tar en fek si yon la rın da ki ola sı ko ru yu cu et ki si hak kın da ki bil gi sı nır lı dır. Bu ça lış ma nın ama cı be ta-glu ka nın As per gil lus fu mi ga tus en fek si yo nu na kar şı ola sı ko ru yu cu et ki le ri ni araş tır -mak tı. G Ge e r re eç ç v ve e Y Yö ön n t te em m l le er r: : Oral be ta-glu kan ve ril me si nin fa re le rin de ney sel ola ...

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Anti-tumor metastatic activity of β-glucan purified from mutated Saccharomyces cerevisiae

Cited by 73 publications

References 23 publications

Use of transfer factor in immunosuppressed surgical patients

Use of transfer factor in immunosuppressed surgical patients

Immunomodulatory effect of mushrooms on cytotoxic activity and cytokine production of intestinal lamina propria leukocytes does not necessarily depend on β-glucan contents

Protective Effect of Beta Glucan on Pulmonary Aspergillosis Model in Neutropenic Rats

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