Protective Effect of Beta Glucan on Pulmonary Aspergillosis Model in Neutropenic Rats

Abstract

A AB BS S T TR RA AC CT T O Ob b j je ec c t ti i v ve e: : Pul mo nary as per gil lo sis is a se ri o us op por tu nis tic in fec ti on which might be fa tal in im mu no com pro mi sed pa ti ents. Im mu nity aga inst as per gil lo sis re qu i res the co or di na ted acti on of com po nents of the in na te and adap ti ve im mu ne systems. Be ta-glu can is one of the im muno mo du la tory agents which got much at ten ti on in re cent ye ars. It was used as a pre ven ti ve agent for the de ve lop ment of in fec ti ons. Ho we ver, in for ma ti on abo ut its the pos sib le pro tec ti ve ef fect on fun gal in fec ti ons are li mi ted. The aim of this study aimed to in ves ti ga te the pos sib le pro tec ti ve effects of be ta-glu can aga inst As per gil lus fu mi ga tus in fec ti on. M Ma a t te e r ri i a al l a an nd d M Me et t h ho od ds s: : We eva lu a ted oral be ta glu can ad mi nis tra ti on for its abi lity to en han ce re sis tan ce of the rats to ex pe ri men tally indu ced pul mo nary as per gil lo sis. Fifty-eight rats we re di vi ded in to thre e gro ups: Thirty fi ve rats were im mu no sup pres sed and in fec ted with As per gil lus fu mi ga tus (in fec ted gro up); 15 we re im mu no sup pres sed, in fec ted and tre a ted with oral be ta-glu can (be ta-glu can gro up); and eight were he althy con trols. Rats we re sac ri fi ced on the tenth day of the ex pe ri ment and tis su e spe ci mens we re cul tu red. Chi tin, ga lac to man nan an ti gen and glu can le vels we re detected. R Re e s su ul lt ts s: : Be ta-glucan en han ced the re sis tan ce aga inst As per gil lus in fec ti on. The sur vi val ra tes we re 62.9 % and 93.4% in the in fec ted and be ta-glu can gro ups, res pec ti vely (p< 0.05). Be ta glu can al so li mi ted the fun gal bur den. C Co on nc c l lu u s si i o on n: : Our re sults sug ges ted that As per gil lus in va si on did not de ve lop in be ta-glu can gro up in spi te of the oc cu ren ce of fun gal co lo ni za ti on in ne ut ro pe nic rats. Be ta-glu can was ab le to im pro ve the re sis tan ce aga inst A. fu mi ga tus in fec ti on. K Ke ey y W Wo or rd ds s: : As per gil lo sis; be ta-glu cans; cytop ro tec ti on; im mu no sup pres si on Ö ÖZ ZE ET T A Am ma aç ç: : Pul mo ner as per gil loz im mün yet mez lik li has ta lar da ölüm cül ola bi len cid di bir fır sat -çı en fek si yon dur. As per jil lo zi se kar şı ba ğı şık lık do ğuş tan ge len ve adap tif im mün sis tem le rin bi leşen le ri nin bir lik te ha re ket et me si ni ge rek ti rir. Be ta-glu kan son yıl lar da çok dik kat çe ken im mü no mo dü la tör ajan lar dan bi ri dir. En fek si yon ge li şi min de ko ru yu cu ajan ola rak kul la nıl mış tır. Fa kat man tar en fek si yon la rın da ki ola sı ko ru yu cu et ki si hak kın da ki bil gi sı nır lı dır. Bu ça lış ma nın ama cı be ta-glu ka nın As per gil lus fu mi ga tus en fek si yo nu na kar şı ola sı ko ru yu cu et ki le ri ni araş tır -mak tı. G Ge e r re eç ç v ve e Y Yö ön n t te em m l le er r: : Oral be ta-glu kan ve ril me si nin fa re le rin de ney sel ola ...