Anti‐tumor effects of interferon in mice injected with interferon‐sensitive and interferon‐resistant friend erythroleukemia cells. VIII. Role of the immune system in the inhibition of visceral metastases

Abstract

DBA/2 mice were injected i.v. with IFN alpha/beta-resistant 3CI8 Friend erythroleukemia cells (FLC) which metastasize to the liver and spleen. IFN alpha/beta treatment of FLC-injected mice increased their survival time and these mice developed a resistance to a second challenge with FLC. The efficacy of IFN alpha/beta in increasing the survival time was compared between normal immunocompetent and immunodeficient mice. The anti-tumor action of IFN was markedly reduced or abolished in newborn DBA/2 mice, in adult athymic nu/nu and beige DBA/2 mice, and in BALB/c scid/scid mice. To determine the phenotype of the effector cells involved, FLC-injected DBA/2 mice were treated with antibodies to asialo-GMI, CD4, or CD8 antigens, or with cyclosporin A or silica. IFN alpha/beta treatment proved much less effective in these mice, indicating that a variety of effector cell types participated in the IFN-induced suppression of visceral metastases. Thus, an intact immune system appears to be essential to obtain optimal therapeutic effects of IFN alpha/beta in this experimental model.

Consensus nomenclature for CD8+T cell phenotypes in cancer

“…8,9 Similarly, the therapeutic effect of local radiotherapy in melanoma, of interferon therapy in leukemia, and of bacille Calmette-Guerin therapy in bladder cancer is abrogated in the absence of CD8 C T cells. [10][11][12] Altogether, these results establish that CD8 C T cells can control spontaneous and carcinogeninduced tumor growth, invasiveness of transplantable cell lines as well as the therapeutic efficacy of some anticancer treatments.…”

Dysregulation of the immune system caused by silica and asbestos

“…Indeed, there is ample evidence that exposure to crystalline silica is associated with an increase in incidence of lung cancers among workers in several occupations (see International Agency for Research on Cancer IARC 1977;Brown, 2009;Erren et al, 2009;Lacasse et al, 2009). There is also a pool of literature that indicates that exposure to silica [by inhalation/other routes (injections)] can affect host resistance to injected/ implanted syngeneic and non-syngeneic tumors (Keller, 1976;Fuji and Murakami, 1983;Sandstrom and Chow, 1987;Gresser et al, 1990); unfortunately, changes in resistance against de novo in situ neoplasias have not been evaluated/ reported in the literature to the same degree. In many of these cited studies, it appeared that the timing of exposure to silica in relation to introduction of the tumor cells was critical, i.e.…”

Synergistic anti‐tumor effects of combined IL‐1/IFN‐α/β therapy in mice injected with met astatic friend erythroleukemia cells

“…2). In this regard, our previous studies suggested that NK cells were involved in the anti-tumor response in IFN-treated (Gresser et al, 1990), but not in IL-UIL-2-treated (Ciolli et al, 1991), FLC-injected mice.…”

“…In particular, the finding that the IL-MFN anti-tumor effect was markedly reduced in mice injected with antibodies to CD4 (Table 11) suggests that T cells, particularly T-helper lymphocytes, are involved in the generation of this anti-tumor response. CD4 + cells have also been shown to play a crucial role in the anti-tumor response in FLC-injected mice treated with IL-1IIL-2 (Ciolli et a/., 1991) or IFN-alp (Gresser et al, 1990).…”