Anti-tumor Effects of Bee Honey on PCNA and P53 Expression in the Rat Hepatocarcinogenesis

El‐kott, Attalla F.; Kandeel, Ahmed A.; El-Az, Sayed F. Abed; Ribea, Heba M.

doi:10.3923/ijcr.2012.130.139

Cited by 18 publications

(20 citation statements)

References 8 publications

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“…Its expression was increased at late G1 stage and early S stage. Previous studies had demonstrated that PCNA labeling index increased sequentially from normal tissue through premalignant stage to carcinoma of various tumors [33,34].…”

Section: Discussionmentioning

confidence: 98%

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The potential protective effect of propolis on experimentally induced hepatitis in adult male albino rats. Histological and immunohistochemical study

El-Mahalaway¹,

Selim²,

Mahboub³

2015

J Histol Histopathol

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Background: In Egypt, liver diseases are one of the most prominent killers especially hepatitis virus infection, fibrosis and cirrhosis. Hepatitis has a serious health effects and alter the functions of the liver. D-galactosamine (D-GalN) and Lipopolysaccharide (LPS) induced hepatitis in rats are closely resembling human viral hepatitis. Propolis is honey bee product with a wide range of beneficial therapeutic effects. Objective: To evaluate the possible protective effect of propolis on experimentally induced hepatitis in adult male albino rats. Materials and methods: Forty adult male rats included and divided equally into 4 groups (10 rats each). group I (control group), group II (Propolis group): The rats received daily oral dose of the propolis (200mg/Kg) by gastric tube for 2 weeks, group III (Hepatitis model group): The rats received single intraperitoneally injection of D-GalN and LPS (300 mg/kg and 30 μg/kg) 18 hours before the end of experiment, group IV (Propolis and hepatitis model group): The rats received daily oral dose of propolis for 2 weeks and D-GalN and LPS 18 hours before the end of experiment. Liver specimens were taken and processed for histological and immunohistochemical study. Results: Group III showed signs of degeneration and necrosis as some swollen hepatocytes had finely granular cytoplasm, other hepatocytes had small hyperchromatic or karyolytic nuclei. Dilated congested, proliferation of endothelial cells of central vein were seen and its wall showed inflammatory cells. There were apparent increase of collagen fibers, significant increase of anti-proliferating cell nuclear antigen (PCNA) positive nuclei among hepatocytes and strong immunoreaction for anti-Transforming growth factor (TGF-β1) in the wall of portal vein. Group IV showed improvement of histological and immunohistochemical changes described before. Conclusion: Propolis has potential protective effect against D-GalN/LPS induced hepatotoxicity in rats as it has antioxidant, anti-inflammatory and antiapoptotic activities.

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Section: Discussionmentioning

confidence: 98%

“…Other investigators had reported that propolis might exert a modulatory effect on cytokine TGF-β1 induced fibrosis [44]. Some doi: 10.7243/2055-091X-2-14 investigators reported that the propolis had antiproliferative and anticarcinogenic activity [34,45].…”

Section: Discussionmentioning

confidence: 99%

The potential protective effect of propolis on experimentally induced hepatitis in adult male albino rats. Histological and immunohistochemical study

El-Mahalaway¹,

Selim²,

Mahboub³

2015

J Histol Histopathol

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“…In liver cancer cells (HepG2), honey treatment led to the suppression of angiogenesis, induction of apoptosis and inhibition of cell proliferation [ 80 ]. A protective effect of honey has been proven also in vivo, on rats with diethylnitrosamine (DEN)-induced hepatic cancer, with up-regulation of p53 [ 81 ]. Similar effects have been found also for bladder cancer, both in vitro (T24, RT4, 253J) and in vivo on mice in which bladder cancer cells (MBT2) were implanted subcutaneously in the abdomens.…”

Section: Honey and Health And Diseasesmentioning

confidence: 99%

Phenolic Compounds in Honey and Their Associated Health Benefits: A Review

et al. 2018

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Honey is a natural substance appreciated for its therapeutic abilities since ancient times. Its content in flavonoids and phenolic acids plays a key role on human health, thanks to the high antioxidant and anti-inflammatory properties that they exert. Honey possesses antimicrobial capacity and anticancer activity against different types of tumors, acting on different molecular pathways that are involved on cellular proliferation. In addition, an antidiabetic activity has also been highlighted, with the reduction of glucose, fructosamine, and glycosylated hemoglobin serum concentration. Honey exerts also a protective effect in the cardiovascular system, where it mainly prevents the oxidation of low-density lipoproteins, in the nervous system, in the respiratory system against asthma and bacterial infections, and in the gastrointestinal system. A beneficial effect of honey can also be demonstrated in athletes. The purpose of this review is to summarize and update the current information regarding the role of honey in health and diseases.

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“…There are limited data on the potential inhibitory effects of honey on hepatic tumorigenesis or carcinogenesis in vivo . A recent study investigated the effect of honey on the development and progression of diethylnitrosamine (DEN)-induced hepatic cancer in rats [57]. After treatment for six months, the liver of untreated DEN-injected rats showed a variety of lesions including inflammatory lymphocytic infiltration, fatty degeneration with displacement of the nucleus, oedema and injured hepatocytes with hyperchromatic nuclei.…”

Section: Effects Of Honey On the Development And Progression Of Tumentioning

confidence: 99%

Effects of Honey and Its Mechanisms of Action on the Development and Progression of Cancer

2014

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Honey is a natural product known for its varied biological or pharmacological activities-ranging from anti-inflammatory, antioxidant, antibacterial, antihypertensive to hypoglycemic effects. This review article focuses on the role of honey in modulating the development and progression of tumors or cancers. It reviews available evidence (some of which is very recent) with regards to the antimetastatic, antiproliferative and anticancer effects of honey in various forms of cancer. These effects of honey have been thoroughly investigated in certain cancers such as breast, liver and colorectal cancer cell lines. In contrast, limited but promising data are available for other forms of cancers including prostate, bladder, endometrial, kidney, skin, cervical, oral and bone cancer cells. The article also underscores the various possible mechanisms by which honey may inhibit growth and proliferation of tumors or cancers. These include regulation of cell cycle, activation of mitochondrial pathway, induction of mitochondrial outer membrane permeabilization, induction of apoptosis, modulation of oxidative stress, amelioration of inflammation, modulation of insulin signaling and inhibition of angiogenesis. Honey is highly cytotoxic against tumor or cancer cells while it is non-cytotoxic to normal cells. The data indicate that honey can inhibit carcinogenesis by modulating the molecular processes of initiation, promotion, and progression stages. Thus, it may serve as a potential and promising anticancer agent which warrants further experimental and clinical studies.

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Anti-tumor Effects of Bee Honey on PCNA and P53 Expression in the Rat Hepatocarcinogenesis

Cited by 18 publications

References 8 publications

The potential protective effect of propolis on experimentally induced hepatitis in adult male albino rats. Histological and immunohistochemical study

The potential protective effect of propolis on experimentally induced hepatitis in adult male albino rats. Histological and immunohistochemical study

Phenolic Compounds in Honey and Their Associated Health Benefits: A Review

Effects of Honey and Its Mechanisms of Action on the Development and Progression of Cancer

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