2012
DOI: 10.3923/ijcr.2012.130.139
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Anti-tumor Effects of Bee Honey on PCNA and P53 Expression in the Rat Hepatocarcinogenesis

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Cited by 18 publications
(20 citation statements)
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“…Its expression was increased at late G1 stage and early S stage. Previous studies had demonstrated that PCNA labeling index increased sequentially from normal tissue through premalignant stage to carcinoma of various tumors [33,34].…”
Section: Discussionmentioning
confidence: 98%
See 1 more Smart Citation
“…Its expression was increased at late G1 stage and early S stage. Previous studies had demonstrated that PCNA labeling index increased sequentially from normal tissue through premalignant stage to carcinoma of various tumors [33,34].…”
Section: Discussionmentioning
confidence: 98%
“…Other investigators had reported that propolis might exert a modulatory effect on cytokine TGF-β1 induced fibrosis [44]. Some doi: 10.7243/2055-091X-2-14 investigators reported that the propolis had antiproliferative and anticarcinogenic activity [34,45].…”
Section: Discussionmentioning
confidence: 99%
“…In liver cancer cells (HepG2), honey treatment led to the suppression of angiogenesis, induction of apoptosis and inhibition of cell proliferation [ 80 ]. A protective effect of honey has been proven also in vivo, on rats with diethylnitrosamine (DEN)-induced hepatic cancer, with up-regulation of p53 [ 81 ]. Similar effects have been found also for bladder cancer, both in vitro (T24, RT4, 253J) and in vivo on mice in which bladder cancer cells (MBT2) were implanted subcutaneously in the abdomens.…”
Section: Honey and Health And Diseasesmentioning
confidence: 99%
“…There are limited data on the potential inhibitory effects of honey on hepatic tumorigenesis or carcinogenesis in vivo . A recent study investigated the effect of honey on the development and progression of diethylnitrosamine (DEN)-induced hepatic cancer in rats [57]. After treatment for six months, the liver of untreated DEN-injected rats showed a variety of lesions including inflammatory lymphocytic infiltration, fatty degeneration with displacement of the nucleus, oedema and injured hepatocytes with hyperchromatic nuclei.…”
Section: Effects Of Honey On the Development And Progression Of Tumentioning
confidence: 99%