The potential protective effect of propolis on experimentally induced hepatitis in adult male albino rats. Histological and immunohistochemical study

El-Mahalaway, Abeer M.; Selim, Amal; Mahboub, Faiza A.

doi:10.7243/2055-091x-2-14

Cited by 24 publications

(26 citation statements)

References 32 publications

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“…El-Mahalaway et al (2015) demonstrated a potential protective effect of propolis against experimentally induced hepatotoxicity (via D-galactosamine (D-GalN)) and lipopolysaccharide (LPS) induced hepatitis in rats. The observed hepatoprotective effect of propolis was attributed to its strong antioxidant, anti-inflammatory, and antiapoptotic activities [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

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Influence of Dietary Supplementation of Propolis and Bee Pollen on Liver Pathology in Broiler Chickens

Klarić

Pavić

Miškulin

et al. 2018

Animals

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Simple SummaryToday, there are increased demands for consumers to use natural products as alternative additives in broiler feeding. In this study, we evaluated the effects of propolis and bee pollen as potential new additives on liver pathology in broilers. The results of this study showed that supplementation of broilers with propolis and/or bee pollen has a strong protective effect on liver pathology. Thus, these natural agents can be used as alternative additives in modern broiler production. Such an approach will enable the production of chicken meat enriched with bioactive substances from propolis and/or bee pollen, such as flavonoids, that have been proven beneficial for human health.AbstractOne of the major problems in intensive breeding of chickens is liver damage. The objective of this study was to determine the influence of dietary supplementation with propolis and bee pollen on liver pathology in broiler chickens. The study was conducted on 200 Ross 308 chickens equally distributed by sex that were divided into five groups. Throughout the whole study, the control group of chickens was fed with a basal diet, while the experimental groups of chickens were fed with the same diet further supplemented with propolis and bee pollen, each supplement given separately or in combination in a certain proportion. The study showed that the clusters of lymphocytes in the hepatocytes, the vacuolar degeneration and necrosis of the liver parenchyma, the bile ductule hyperplasia, and the various forms of pathological changes in the liver arteries and veins were more frequent in liver tissue samples of the control group compared to liver tissue samples of all the experimental groups (p < 0.001). The study further showed that all the previously mentioned histopathological lesions of liver tissue were always more extensive in the liver tissue samples of the control group than in the liver tissue samples of all the experimental groups (p < 0.001). The supplementation of broiler chickens with propolis and/or bee pollen has a strong protective effect on liver pathology in broiler chickens.

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Section: Discussionmentioning

confidence: 99%

“…The liver is a vital organ that plays a key role in the detoxification of exogenous and endogenous substances. It also performs a wide range of metabolic activities required for homeostasis, nutrition, and immune defense [ 13 ]. Subclinical infections are a major problem in broiler breeding and also result in liver damage [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Influence of Dietary Supplementation of Propolis and Bee Pollen on Liver Pathology in Broiler Chickens

Klarić

Pavić

Miškulin

et al. 2018

Animals

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“…Lung ( Figure 3b) and liver (Figure 3c) lesions were regressed in this group when compared to Group II, no histopathological lesions were detected in the kidney, liver, and lung tissues of Group V and VI in which sepsis was not created and only low-dose and high-dose CR were administered. There are studies showing that the application of propolis in LPS-induced organ damage can preven histopathological lesions (Doğanyiğit et al, 2013;El-Mahalaway, Selim, & Mahboub, 2015;Ramadan, Soliman, Sawsan, Salwa & Abdel-Rahman, 2015).…”

Section: Histopathological Evaluationmentioning

confidence: 99%

The effects of chrysin on lipopolysaccharide‐induced sepsis in rats

et al. 2020

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Chrysin (CR) is a flavone found in propolis and many plants. Lipopolysaccharide (LPS) is a component of the cell wall of gram‐negative bacteria that causes sepsis. The purpose of this study was to investigate the effects of CR on LPS‐induced sepsis in rats. LPS intraperitoneal and a single dose and CR were given orally for 10 days. Rats were sacrificed, blood samples were taken, liver, lung, and kidney tissues were dissected, homogenized, and histopathological analysis was carried out. When CR groups compared to sepsis group, CR significantly decreased the serum levels of aspartate transaminase (AST) and alanine aminotransferase (ALT), interleukin‐1 beta (IL‐1β), interleukin‐10 (IL‐10), tumor necrosis factor‐α (TNF‐α), interleukin‐6 (IL‐6), and levels of malondialdehyde (MDA) in tissues. CR also increased the levels of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH‐Px) in tissues. Histopathological findings were consistent with biochemical findings. Conclusion, CR could reduce the oxidative stress markers and cytokines in sepsis. Practical applications Our approach is to determine the antioxidant and anti‐inflammatory effects of chrysin, known as a flavolonoid, which are found in many plants and foods such as honey and propolis. In this study, experimental sepsis model was created using LPS. According to the results of the study, CR can attribute to the ameliorating of oxidative damage in tissues (lung, liver, and kidney) and it can suppress the sepsis‐associated acute tissue injury via reduction of inflammation in rats. Even, CR can be used as a pharmacological agent in inflammatory diseases caused by other sources and in many cases causing oxidation.

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“…Although there have not been established comprehensive protective mechanisms in different species so far, there is an ever-increasing evidence of curcumin-mediated ameliorative role in aflatoxicosis. Curcumin has been reported to demonstrate protective function in AFB1 inflicted damage to liver, kidneys, and overall growth parameters, mainly in ducks, chickens, and rodents [ 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 ].…”

Section: Curcumin-mediated Afb1 Toxicity Control and Protective Mementioning

confidence: 99%

Protective and Detoxifying Effects Conferred by Dietary Selenium and Curcumin against AFB1-Mediated Toxicity in Livestock: A Review

Limaye

Chou

et al. 2018

Toxins

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Aflatoxin B1 (AFB1), among other aflatoxins of the aflatoxin family, is the most carcinogenic and hazardous mycotoxin to animals and human beings with very high potency leading to aflatoxicosis. Selenium is an essential trace mineral possessing powerful antioxidant functions. Selenium is widely reported as an effective antioxidant against aflatoxicosis. By preventing oxidative liver damage, suppressing pro-apoptotic proteins and improving immune status in AFB1 affected animals; selenium confers specific protection against AFB1 toxicity. Meticulous supplementation of animal feed by elemental selenium in the organic and inorganic forms has proven to be effective to ameliorate AFB1 toxicity. Curcumin is another dietary agent of importance in tackling aflatoxicosis. Curcumin is one of the major active ingredients in the tubers of a spice Curcuma longa L., a widely reported antioxidant, anticarcinogenic agent with reported protective potential against aflatoxin-mediated liver damage. Curcumin restricts the aflatoxigenic potential of Aspergillus flavus. Curcumin inhibits cytochrome P450 isoenzymes, particularly CYP2A6 isoform; thereby reducing the formation of AFB1-8, 9-epoxide and other toxic metabolites causing aflatoxicosis. In this review, we have briefly reviewed important aflatoxicosis symptoms among animals. With the main focus on curcumin and selenium, we have reviewed their underlying protective mechanisms in different animals along with their extraction and production methods for feed applications.Keywords: aflatoxin B1; anti-AFB1 dietary supplement; curcumin; selenium; antioxidant status Key contribution: We have reviewed protective roles of selenium and curcumin in specific relation to tacking AFB1 toxicity in the livestock along with their reported underlying mechanisms for the potential feed applications catering across a broad host range.

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The potential protective effect of propolis on experimentally induced hepatitis in adult male albino rats. Histological and immunohistochemical study

Cited by 24 publications

References 32 publications

Influence of Dietary Supplementation of Propolis and Bee Pollen on Liver Pathology in Broiler Chickens

Influence of Dietary Supplementation of Propolis and Bee Pollen on Liver Pathology in Broiler Chickens

The effects of chrysin on lipopolysaccharide‐induced sepsis in rats

Protective and Detoxifying Effects Conferred by Dietary Selenium and Curcumin against AFB1-Mediated Toxicity in Livestock: A Review

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