Anti-tumor, Anti-oxidant and Anti-microbial potential of Nymphaea alba and Nymphaea mexicana flowers a comparative study

Nazir, Shaista

doi:10.19046/abp.v02i04.06

Cited by 5 publications

(3 citation statements)

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“…N. alba species contain antioxidant polyphenols, flavonoids and derived acids such as caffeic acid, ferulic acid, quinic acid, p-coumaric acid, gallic acid, quercetin, luteolin, orientin, catechin, epicatechin, naringin, naringenin and rutin phytochemicals that have shown inhibitory effects on different phases of cell cycle and are also responsible for inducing apoptosis by regulating the expression of different apoptotic signaling pathways [22][23][24]. Flower extracts of the Nymphaea genus have been reported to have antineoplastic effects in different types of cancer, including leukemia, lung cancer, colon cancer and prostate cancer [25]. However, there is little evidence of their antineoplastic effects on ovarian and breast cancer cells.…”

Section: Introductionmentioning

confidence: 99%

Antifungal, Antitumoral and Antioxidant Potential of the Danube Delta Nymphaea alba Extracts

et al. 2019

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This study aimed to explore for the first time the biological properties such as antifungal, antitumoral and antioxidant of Danube Delta Nymphaea alba (N. alba) leaf and root methanolic extracts. The toxicity studies of N. alba extracts showed no inhibitory effect on wheat seed germination by evaluating the most sensitive physiological parameters (Germination %, Germination index, Vigor index) and using confocal laser scanning microscopy images. The analyzed extracts were found to have high antifungal activity against Candida glabrata with MIC values of 1.717 µg/mL for leaf and 1.935 µg/mL for root. The antitumor activity of the both extracts against A2780/A2780cisR ovarian, LNCaP prostate and MCF-7 breast cancer cells was promising with IC50 values ranging from 23–274 µg/mL for leaf and 18–152 µg/mL for root, and the combination of N. alba extracts with cisplatin showed a synergistic effect (coefficient of drug interaction <1). The antioxidant properties were assessed by β-carotene bleaching, ABTS and FRAP assays and cyclic voltammetry. Quercetin, the most prominent antioxidant, was quantified in very good yields by spectroelectrochemical assay.

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Section: Introductionmentioning

confidence: 99%

Antifungal, Antitumoral and Antioxidant Potential of the Danube Delta Nymphaea alba Extracts

et al. 2019

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“…Rat cardiac H9c2 cells of rat heart were cultured in DMEM enriched with bovine serum penicillin–streptomycin at 37 °C in a humidified atmosphere and used to assess the in vitro cytotoxicity of different concentration of ATV given in solution or in the form of ATVNP dispersion containing ATV (equivalent to 0.01, 0.1, 1.0 and 10.0 mg/100 µl of ATV). The H9c2 cells were exposed to samples under conditions of hypoxia for 24 h after washing with PBS ( Nazir and Chat, 2015 ).…”

Section: Methodsmentioning

confidence: 99%

Nano-particle engineered atorvastatin delivery to support mesenchymal stem cell survival in infarcted myocardium

Guangtao¹,

Song²,

Xue³

et al. 2018

Saudi Journal of Biological Sciences

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Atorvastatin (ATV) may support mesenchymal stem cells (MSC) survival in post-infarct myocardium (MI) as inflammatory reactions, oxidative stress and hypoxia condition get started in such tissues after damage. However, limited aqueous insolubility and rapid first-pass metabolism reduce the systemic availability of ATV. The aim of the present investigation was to develop ATV loaded nanoparticles (ATVNPs) which might ensure the maximum availability of ATV in systemic circulation for longer duration and to strengthen the support to MSC survival. ATVNPs were synthesized using double emulsion solvent evaporation method and characterized as spherical shape, positive charged, nanoparticles of uniform size distribution and higher entrapment efficiency. ATVNPs were non-cytotoxic and showed sustained release (up to 28 days). Assessment of cardiac function (in terms of echocardiographic and left heart catheterization parameters) and cytokines estimation revealed efficient improvement in post-infarct myocardium condition of rat. In conclusion, ATVNP was developed successfully that may ensure safe, cost effective, and efficacious treatment of post-infarct myo-cardium when compared with that of MSC alone and MSC supplemented with ATV solution.

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“…The genus Nymphaea comprises about forty-fifty species, [15] out of which five species are present in India. [16] N. alba belongs to the Nymphaeaceae family.…”

Section: Abstract a R T I C L E I N F Omentioning

confidence: 99%

In vivo and in vitro Antidiabetic Characterization of Nymphaea alba leaves

Singh

Agnihotri²,

Verma³

2020

Int. J. Pharm. Sci. Drug Res.

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The study was aimed to trace out antihyperglycemic potentials of Nymphaea alba leaves using in vitro and in vivo approaches. In, in vitro study, determination of IC50 of Nymphaea alba extracts was done using α-amylase and α-glucosidase inhibition assay. In α-amylase, Nymphaea alba methanol extract (NAME) exhibited maximum inhibition 56.77±1.23% at 125µg/ml in comparison to 66.7±0.94 % of standard acarbose. In α-glucosidase, NAME exhibits 59.89±0.92, while standard acarbose showed 70.31±1.25 % inhibition. The in vivo study was performed on diabetic rats, made diabetic by Streptozotocin. 200mg/kg and 400mg/kg NAME was administered orally, which significantly (

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Anti-tumor, Anti-oxidant and Anti-microbial potential of Nymphaea alba and Nymphaea mexicana flowers a comparative study

Cited by 5 publications

References 0 publications

Antifungal, Antitumoral and Antioxidant Potential of the Danube Delta Nymphaea alba Extracts

Antifungal, Antitumoral and Antioxidant Potential of the Danube Delta Nymphaea alba Extracts

Nano-particle engineered atorvastatin delivery to support mesenchymal stem cell survival in infarcted myocardium

In vivo and in vitro Antidiabetic Characterization of Nymphaea alba leaves

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