Anti-tumor activities and mechanisms of Traditional Chinese medicines formulas: A review

Fan, Yuyang; Ma, Zhe; Zhao, Lulu; Wang, Wei; Gao, Mengyuan; Jia, Xiaohua; Ouyang, Hongwei; He, Jun

doi:10.1016/j.biopha.2020.110820

Cited by 49 publications

(23 citation statements)

References 142 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…and trace elements required by the human body, thus promoting the recovery of hepatitis patients [13] . Therefore, these three kinds of liver protective drugs exert complementary therapeutic effects from different mechanisms of action.…”

Section: Resultsmentioning

confidence: 99%

Clinical Efficacy of Diammonium Glycyrrhizinate on Drug Induced Liver Injury and Influence on Related Inflammatory Factors

Luo¹,

CHEN²

2021

ijps

View full text Add to dashboard Cite

Luo et al.: Clinical Efficacy of Diammonium Glycyrrhizinate on DILITo assess the clinical efficacy of diammonium glycyrrhizinate on drug induced liver injury and its effect on related inflammatory factors in the real world. A total of 234 inpatients diagnosed with drug induced liver injury in our hospital were continuously enrolled in this retrospective real world study, of whom 110 were treated with diammonium glycyrrhizinate and divided into three groups according to drug combination. Treatment group A (n=34) received diammonium glycyrrhizinate injection+reduced glutathione injection, treatment group B (n=45) received Kuhuang injection based on administration for treatment group A, and treatment group C (n=31) received ursodeoxycholic acid capsules based on administration for treatment group B. The remaining 124 cases did not undergo diammonium glycyrrhizinate treatment, including 37 cases in control group A receiving reduced glutathione injection alone, 55 cases in control group B receiving Kuhuang injection based on treatment for control group A, and 32 cases in control group C receiving ursodeoxycholic acid capsules based on treatment for control group B. The treatment lasted for 2 w. The biochemical indices such as serum gamma glutamyl transpeptidase, total bilirubin, alkaline phosphatase, glutamic pyruvic transaminase, tumor necrosis factor-α and interleukin-6 were observed before treatment and 1 w and 2 w after treatment, and adverse reactions were recorded. The efficacy was evaluated and compared. Compared with before treatment, the levels of alkaline phosphatase, glutamic pyruvic transaminase, tumor necrosis factor-α, interleukin-6 and total bilirubin in treatment group A, the levels of alkaline phosphatase, glutamic pyruvic transaminase, gamma glutamyl transpeptidase, tumor necrosis factor-α, interleukin-6 and total bilirubin in treatment group B, and the levels of alkaline phosphatase, glutamic pyruvic transaminase, tumor necrosis factor-α, interleukin-6 and gamma glutamyl transpeptidase in treatment group C all significantly declined (p<0.05). The levels of total bilirubin, tumor necrosis factor-α and interleukin-6 significantly declined in control group C (p<0.05), while the changes in biochemical indices had no significant differences in other control groups (p>0.05). Compared with before treatment, the levels of tumor necrosis factor-α, interleukin-6 and total bilirubin in treatment group A, the levels of alkaline phosphatase, glutamic pyruvic transaminase, tumor necrosis factor-α, interleukin-6 and gamma glutamyl transpeptidase in treatment group B, and the levels of alkaline phosphatase, tumor necrosis factor-α and interleukin-6 in treatment group C significantly declined (p<0.05), but the level of total bilirubin in treatment group C significantly rose (p<0.05). The response rates in treatment group A and B were higher than those in control group A and B, respectively (p<0.05), but it was lower in treatment group C than that in control group C (p<0.05). The response rates in treatment group A a...

show abstract

Section: Resultsmentioning

confidence: 99%

Clinical Efficacy of Diammonium Glycyrrhizinate on Drug Induced Liver Injury and Influence on Related Inflammatory Factors

Luo¹,

CHEN²

2021

ijps

View full text Add to dashboard Cite

show abstract

“…At present, due to the overall regulatory effect of TCM on human body and low toxicity and side effects, the research on diseases including CRC is increasing all over the world ( Fan et al, 2020 ). At the same time, great progress has been made in its pharmacological research and clinical application.…”

Section: Antitumor Status Of Traditional Chinese Medicine and Its Clinical Trials On Colorectal Cancermentioning

confidence: 99%

Traditional Chinese Medicine and Colorectal Cancer: Implications for Drug Discovery

Sun

Zhang

et al. 2021

Front. Pharmacol.

View full text Add to dashboard Cite

As an important part of complementary and alternative medicine, traditional Chinese medicine (TCM) has been applied to treat a host of diseases for centuries. Over the years, with the incidence rate of human colorectal cancer (CRC) increasing continuously and the advantage of TCM gradually becoming more prominent, the importance of TCM in both domestic and international fields is also growing with each passing day. However, the unknowability of active ingredients, effective substances, and the underlying mechanisms of TCM against this malignant tumor greatly restricts the translation degree of clinical products and the pace of precision medicine. In this review, based on the characteristics of TCM and the oral administration of most ingredients, we herein provide beneficial information for the clinical utilization of TCM in the prevention and treatment of CRC and retrospect the current preclinical studies on the related active ingredients, as well as put forward the research mode for the discovery of active ingredients and effective substances in TCM, to provide novel insights into the research and development of innovative agents from this conventional medicine for CRC treatment and assist the realization of precision medicine.

show abstract

“…A number of studies have shown that snake gallbladder possesses a variety of activities, including anti-inflammatory, anti-asthmatic, antitussive, expectorant and bacteriostatic. Interestingly, several studies have demonstrated the immune regulatory as well as blood pressure lowering effects of gallbladder in different animal and human studies [28][29][30][31][32].…”

Section: Snake Gallbladdermentioning

confidence: 99%

“…Protect against fibrosis, superoxide formation, and lower serum triglyceride; protect from cell death and antivascular spasm; anti-inflammatory effects [7,20,[31][32][33][34][35][36] Although no significant effects on cell proliferation were observed, PZH was able to regulate a series of responsive elements, mediated by AP-1, CRE and NF-κB, in hepatoma cells [55]. This hepatoprotective effect was not altered even after the substitution for natural musk (nPZH) with a formulated PZH substitute (sPZH) [57].…”

Section: Hepatoprotective Effects Molecular Mechanisms Of Pzh-mediatementioning

confidence: 99%

Pien Tze Huang (PZH) as a Multifunction Medicinal Agent in Traditional Chinese Medicine (TCM): a review on cellular, molecular and physiological mechanisms

Chen¹

2021

Cancer Cell Int

View full text Add to dashboard Cite

Relevance Pien Tze Huang (PZH) is a well-known Traditional Chinese Medicine (TCM), characterized by a multitude of pharmacological effects, such as hepatoprotection and inhibition of inflammation and cell proliferative conditions. Many of these effects have been validated at the cellular, molecular and physiological levels but, to date, most of these findings have not been comprehensively disclosed. Objectives This review aims to provide a critical summary of recent studies focusing on PZH and its multiple pharmacological effects. As a result, we further discuss some novel perspectives related to PZH’s mechanisms of action and a holistic view of its therapeutic activities. Methods A systematic review was performed focusing on PZH studies originated from original scientific resources. The scientific literature retrieved for this work was obtained from International repositories including NCBI/PubMed, Web of Science, Science Direct and China National Knowledge Infrastructure (CNKI) databases. Results The major active componentes and their potential functions, including hepatoprotective and neuroprotective effects, as well as anti-cancer and anti-inflammatory activities, were summarized and categorized accordingly. As indicated, most of the pharmacological effects were validated in vitro and in vivo. The identification of complex bioactive components in PZH may provide the basis for further therapeutic initiatives. Conclusion Here we have collectively discussed the recent evidences covering most, if not all, pharmacological effects driven by PZH. This review provides novel perspectives on understanding the modes of action and the holistic view of TCM. The rational development of future clinical trials will certainly provide evidence-based medical evidences that will also confirm the therapeutic advantages of PZH, based on the current information available.

show abstract

Anti-tumor activities and mechanisms of Traditional Chinese medicines formulas: A review

Cited by 49 publications

References 142 publications

Clinical Efficacy of Diammonium Glycyrrhizinate on Drug Induced Liver Injury and Influence on Related Inflammatory Factors

Clinical Efficacy of Diammonium Glycyrrhizinate on Drug Induced Liver Injury and Influence on Related Inflammatory Factors

Traditional Chinese Medicine and Colorectal Cancer: Implications for Drug Discovery

Pien Tze Huang (PZH) as a Multifunction Medicinal Agent in Traditional Chinese Medicine (TCM): a review on cellular, molecular and physiological mechanisms

Contact Info

Product

Resources

About