Anti-trypanosomal activity of African medicinal plants: A review update

Ibrahim, Mohammed Auwal; Mohammed, A.; Isah, Murtala Bindawa; Aliyu, A. B.

doi:10.1016/j.jep.2014.04.012

Cited by 72 publications

(53 citation statements)

References 53 publications

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“…Isolate KETRI 3486 was more susceptible to the two standard drugs compared to Bidens pilosa with melarsoprol having the lowest MIC of 0.27ng/ml. Similar antitrypanosomal activity of the standard drugs were observed by Sara et al, [14].…”

Section: Discussionsupporting

confidence: 86%

Evaluation of Trypanocidal Activity of Bidens pilosa and Physalis peruviana Against Trypanosoma brucei rhodesiense

Mwaniki¹

2017

AJLM

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Abstract:Trypanosomiasis is a protozoan disease that causes death and morbidity to man, and also severely limits livestock productivity in endemic areas. It is caused by different species of trypanosomes that occur in Africa, South America and Asia. Although chemotherapy is the main method of trypanosomiasis control, the few drugs in the market are faced with challenges of drug resistance, high toxicity and very costly. There is also no likelihood of a vaccine to control new outbreaks and there are no new drugs in the market. Herbal medicines are increasingly being used as an alternative solution to the control of trypanosomiasis in endemic areas. These are cost effective and economic friendly. The purpose of this study was to evaluate trypanocidal activity of Bidens Pilosa and Physalis peruviana using in-vitro and in-vivo protocols. The in-vitro trials are carried out using 96 well plates where the trypanocidal activities of the plant extracts were evaluated by calculating the minimum inhibition concentration (MIC). Toxicity of the herbal extract was determined by monitoring survival, weight change, lethargy and difficulty in breathing. Parasitemia development after extract administration was used as parameters to test the test compound for trypanocidal activity. In vitro results revealed that bidens pilosa had the highest activity with an MIC of 125µg/ml after 48 hours of incubation against Trypanosoma brucei rhodensiense isolated from a patient in busia (KETRI 3684). Toxicity results showed that a dosage level of above 1000mg/kg body weight (highest toxicity trial dose used) of bidens pilosa caused clinical signs such as difficulty in breathing, lethargy, raised hair, loss of weight and death within five days. Invivo results revealed that Bidens pilosa had some trypanocidal effect but did not perform better than the standard drugs. It is recommend that repeat therapy could be done to clear the parasites completely. Combined therapy of bidens pilosa and physalis peruviana was recommended to see if results can create a rationale for combination therapy in elimination of the parasites. This study has showed that Bidens pilosa and Physalis peruviana have trypanocidal potential.

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Section: Discussionsupporting

confidence: 86%

Evaluation of Trypanocidal Activity of Bidens pilosa and Physalis peruviana Against Trypanosoma brucei rhodesiense

Mwaniki¹

2017

AJLM

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“…Others were Diospyros verrucosa root bark (DVRM) methanol extract (IC 50 : 2.23 μg/ml), Diospyros natalensis stem bark (DNSM) methanol extract (IC 50 : 2.85 μg/ml), and Diospyros verrucosa leaves (DVLM) methanol extract (IC 50 : 2.99 μg/ml). Most of these extracts from the genus Diospyros showed good activities compared to the literature data for Diospyros mespiliformis leaves which exhibited antitrypanosomal activity against Trypanosoma brucei brucei at the MIC value of 500 μg/ml [17].…”

Section: In Vitro Antitrypanosomal Activitymentioning

confidence: 67%

“…The genus Diospyros is known for various traditional medicinal uses including for the treatment of HAT, malaria, headache, diarrhea, dysentery, stomach ache, and inflammatory conditions [11][12][13][14][15][16][17][18]. According to interviewed natives during the field excursion, Diospyros natalensis is used as a herbal remedy for the treatment of fever and internal body pain [19].…”

mentioning

confidence: 99%

Antitrypanosomal, antiplasmodial, and antibacterial activities of extracts from selected Diospyros and Annonaceae species

Christopher¹,

Mgani²,

Nyandoro³

et al. 2018

J Complement Med Res

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“…Plant extracts have been found to have antitrypanosomal activity against trypanosomes in different plant extracts evaluated in vitro [20]. Considering the previous reports on C. swynnertonii extracts activity, there is none which directly underpins the basis of our current study.…”

Section: Introductionmentioning

confidence: 93%

Trypanocidal activity of ethanolic extracts of Commiphora swynnertonii Burtt on Trypanosoma congolense

Nagagi

Silayo

Kweka

2016

BMC Complement Altern Med

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BackgroundAfrican trypanosomosis is the disease caused by extracellular protozoan parasites of the genus Trypanosoma transmitted by tsetse flies. The current study has evaluated the trypanocidal activity of Commiphora swynnertonii extracts on Trypanosoma congolense.MethodsThe effect of ethanolic stem bark and resinous extracts on motility of T. congolense was evaluated by in vitro study at concentrations of 2 mg/ml and 4 mg/ml. Then, trypanocidal activity was evaluated by drug incubation infectivity test using mice at concentrations of 0.4 mg/ml and 2 mg/ml. In both studies negative (without drug) and positive (diminazene diaceturate) controls were used.ResultsThe in vitro study showed that, ethanolic stem bark extract of C. swynnertonii at concentration of 4 mg/ml caused complete cessation of motility for T. congolense in 30 min. However, resinous ethanolic extract had delayed effect on cessation of motility of T. congolense observed at 90 and 100 min post-incubation at concentrations of 4 mg/ml and 2 mg/ml respectively. The drug incubation infectivity test study depicted that ethanolic stem bark extract at concentration of 2 mg/ml significantly (p = 0.000) reduced the infectivity of T. congolense in mice. However, it did not vary significantly (P =0.897) with group treated with diminazene diaceturate incubated mixture.ConclusionThe current study has provided evidence that, ethanolic stem bark extract of C. swynnertonii possess trypanocidal activity against T. congolense. Based on these findings, further studies are recommended to determine its potential as a lead to trypanocidal drug discovery.

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Anti-trypanosomal activity of African medicinal plants: A review update

Cited by 72 publications

References 53 publications

Evaluation of Trypanocidal Activity of <i>Bidens pilosa</i> and <i>Physalis peruviana</i> Against <i>Trypanosoma brucei rhodesiense</i>

Evaluation of Trypanocidal Activity of <i>Bidens pilosa</i> and <i>Physalis peruviana</i> Against <i>Trypanosoma brucei rhodesiense</i>

Antitrypanosomal, antiplasmodial, and antibacterial activities of extracts from selected Diospyros and Annonaceae species

Trypanocidal activity of ethanolic extracts of Commiphora swynnertonii Burtt on Trypanosoma congolense

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Anti-trypanosomal activity of African medicinal plants: A review update

Cited by 72 publications

References 53 publications

Evaluation of Trypanocidal Activity of &lt;i&gt;Bidens pilosa&lt;/i&gt; and &lt;i&gt;Physalis peruviana&lt;/i&gt; Against &lt;i&gt;Trypanosoma brucei rhodesiense&lt;/i&gt;

Evaluation of Trypanocidal Activity of &lt;i&gt;Bidens pilosa&lt;/i&gt; and &lt;i&gt;Physalis peruviana&lt;/i&gt; Against &lt;i&gt;Trypanosoma brucei rhodesiense&lt;/i&gt;

Antitrypanosomal, antiplasmodial, and antibacterial activities of extracts from selected Diospyros and Annonaceae species

Trypanocidal activity of ethanolic extracts of Commiphora swynnertonii Burtt on Trypanosoma congolense

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Evaluation of Trypanocidal Activity of <i>Bidens pilosa</i> and <i>Physalis peruviana</i> Against <i>Trypanosoma brucei rhodesiense</i>

Evaluation of Trypanocidal Activity of <i>Bidens pilosa</i> and <i>Physalis peruviana</i> Against <i>Trypanosoma brucei rhodesiense</i>