Antitrypanosomal, antiplasmodial, and antibacterial activities of extracts from selected Diospyros and Annonaceae species

Christopher, Robert; Mgani, Quintino A.; Nyandoro, Stephen S.; Rousseau, Amanda L.; Vuuren, S.F. Van; Isaacs, Michelle; Hoppe, Heinrich C.

doi:10.5455/jcmr.20171205011734

Cited by 8 publications

(3 citation statements)

References 16 publications

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“…In Mogovolas district, medicinal plants play a major role in the treatment of malaria. There is scientific evidence of the effectiveness for almost half of the identified species (19/37), which were tested for antiplasmodial activity [ 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 ].…”

Section: Discussionmentioning

confidence: 99%

Ethnobotanical study of plants used by the traditional healers to treat malaria in Mogovolas district, northern Mozambique

Manuel

Bechel

Noormahomed

et al. 2020

Heliyon

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Introduction Malaria is an important parasitic disease that affects mostly the African continent. Traditional medicine is very important in Mozambique and traditional healers play a key role in the primary health care services, particularly in rural areas. We aim to report the results of an ethnobotanical survey undertaken in Mogovolas district, northern region of Mozambique. We recorded and identified the medicinal plants used by traditional healers for treatment of malaria, as well as the mode of preparation and administration. Methods The study was conducted in 14 villages from Mogovolas between June and August 2015. Sixteen traditional healers were interviewed using semi-structured questionnaires. Under their guidance, we collected medicinal plants and prepared herbarium specimens that were sent and kept at Eduardo Mondlane University Herbarium for scientific identification. We searched for information on the in vitro and in vivo studies of the cited plants for antiplasmodial activity. Results Traditional healers from Mogovolas district reported the use of 37 plants to treat malaria, belonging to 22 families. The most used species are Ochna kirkii Oliv. (5 citations), Ehretia amoena Klotzsch and Pteleopsis myrtifolia (M.A.Lawson) Engl. & Diels (both with 3 citations). These plants belong to Ochnaceae, Boraginaceae and Combretaceae families, respectively. The herbal remedies are prepared using leaves (22/37), roots (18/37), stem barks (16/37) and stems (3/37). The administration of the herbal remedies was made essentially by oral route and bathing. Conclusion The ethnobotanical data resulted from this study can be the starting point for further chemical and pharmacological studies aiming to identify medicinal species with antimalarial activity, thus, open the insights for the discovery of new antimalarial substances, as well as better integration of the traditional medicine into the national health systems, particularly in developing countries, as the health system coverage is limited.

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Section: Discussionmentioning

confidence: 99%

Ethnobotanical study of plants used by the traditional healers to treat malaria in Mogovolas district, northern Mozambique

Manuel

Bechel

Noormahomed

et al. 2020

Heliyon

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“…The antiparasitic activity against Leishmania donovani, Trypanosoma cruzi, and Trypanosoma brucei was confirmed in several studies on Diospyros species [99]. For example, an acetate leaf extract of D. abyssinica and the isodiospyrin and diospyrin marker compounds isolated from the bark by bioguided fractionation showed high anti-L. donovani activity (IC 50 = 1.5 g/mL, extract, and IC 50 = 0.5 g/mL, isolated compounds) [65].…”

Section: Antiparasitic Activitymentioning

confidence: 76%

“…In vitro studies from methanolic extracts of D. abyssinica leaves have provided confirmation of its antiparasitic activity against Leishmania donovani [65,94], Trypanosoma cruzi, Trypanosoma brucei [99], Culex, and Anopheles larvae [94].…”

Section: Antiparasitic Activitymentioning

confidence: 96%

The Genus Diospyros: A Review of Novel Insights into the Biological Activity and Species of Mozambican Flora

Ribeiro,

Serrano,

da Silva

et al. 2023

Plants

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Species of the Diospyros L. genus (Ebenaceae family) have been largely used in traditional medicine for the treatment of several diseases, especially infectious ones. To date, active major compounds such as naphthoquinones, triterpenoids, and tannins have been isolated and pharmacologically validated from Diospyros species. The present study summarizes the information available in the literature on the species described in the Flora of Mozambique. To do so, scientific databases (e.g., PubMed, Scopus, Web of Science, and Google Scholar) were searched using various keywords and Boolean connectors to gather and summarize the information. Of the 31 native and naturalized species in the Flora of Mozambique, 17 are used in different regions of Africa and were described for their traditional uses. They were reported to treat more than 20 diseases, mostly infectious, in the gastrointestinal and oral cavity compartments. This work provides an overview of the therapeutical potential of Diospyros species and explores novel insights on the antimicrobial potential of extracts and/or isolated compounds of these Mozambican species.

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Phytochemistry, pharmacology and medicinal uses of Cola (Malvaceae) family: a review

Ekalu

Habila

2020

Med Chem Res

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Antitrypanosomal, antiplasmodial, and antibacterial activities of extracts from selected Diospyros and Annonaceae species

Cited by 8 publications

References 16 publications

Ethnobotanical study of plants used by the traditional healers to treat malaria in Mogovolas district, northern Mozambique

Ethnobotanical study of plants used by the traditional healers to treat malaria in Mogovolas district, northern Mozambique

The Genus Diospyros: A Review of Novel Insights into the Biological Activity and Species of Mozambican Flora

Phytochemistry, pharmacology and medicinal uses of Cola (Malvaceae) family: a review

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