Anti-trypanosomal activity of (8-hydroxymethylen)-trieicosanyl acetate against infective forms of Trypanosoma cruzi

Jiménez‐Coello, Matilde; Acosta-Viana, Karla Y.; Guzmán-Marín, Eugenia; Gonzalez, Cuahutemoc Perez; Gutiérrez, M

doi:10.3109/13880200903241853

Cited by 8 publications

(4 citation statements)

References 27 publications

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“…Natural products isolated from different botanical sources exhibited activity against T. cruzi (see Table 2). [120][121][122][123][124][125][126][127][128][129][130][131][132] Several approaches have been developed focusing on identification and isolation of plantbased products with anti-T. cruzi activity 133,134 (Table 2). In this sense, extracts from different plants as Salvia, Valeriana, Hypericum, Silybum, Arnica, and Curcuma showed activity against T. cruzi.…”

Section: Natural Productsmentioning

confidence: 99%

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Review on Experimental Treatment Strategies Against Trypanosoma cruzi

Mazzeti

Capelari-Oliveira

Bahia

et al. 2021

JEP

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Chagas disease is a neglected tropical disease caused by the protozoan Trypanosoma cruzi . Currently, only nitroheterocyclic nifurtimox (NFX) and benznidazole (BNZ) are available for the treatment of Chagas disease, with limitations such as variable efficacy, long treatment regimens and toxicity. Different strategies have been used to discover new active molecules for the treatment of Chagas disease. Target-based and phenotypic screening led to thousands of compounds with anti- T. cruzi activity, notably the nitroheterocyclic compounds, fexinidazole and its metabolites. In addition, drug repurposing, drug combinations, re-dosing regimens and the development of new formulations have been evaluated. The CYP51 antifungal azoles, as posaconazole, ravuconazole and its prodrug fosravuconazole presented promising results in experimental Chagas disease. Drug combinations of nitroheterocyclic and azoles were able to induce cure in murine infection. New treatment schemes using BNZ showed efficacy in the experimental chronic stage, including against dormant forms of T. cruzi . And finally, sesquiterpene lactone formulated in nanocarriers displayed outstanding efficacy against different strains of T. cruzi , susceptible or resistant to BNZ, the reference drug. These pre-clinical results are encouraging and provide interesting evidence to improve the treatment of patients with Chagas disease.

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Section: Natural Productsmentioning

confidence: 99%

“…Isolated compound showed in vitro and in vivo activity against T. cruzi. [122,125] Zanthoxylum chiloperone…”

Section: Senna Villosa (8-hydroxymethylen)-trieicosanyl Acetatementioning

confidence: 99%

Review on Experimental Treatment Strategies Against Trypanosoma cruzi

Mazzeti

Capelari-Oliveira

Bahia

et al. 2021

JEP

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“…An aqueous extract is also used for the treatment of irregular menstruation and inflammatory problems [32]. It has been reported to have trypanocidal and antiprotozoal activities [33,34,35,36,37,38]. However, the anti-inflammatory activity of this plant and its active components has not yet been systematically studied.…”

Section: Introductionmentioning

confidence: 99%

Bioassay-Guided Chemical Study of the Anti-Inflammatory Effect of Senna villosa (Miller) H.S. Irwin & Barneby (Leguminosae) in TPA-Induced Ear Edema

et al. 2014

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Senna villosa (Miller) is a plant that grows in México. In traditional Mexican medicine, it is used topically to treat skin infections, pustules and eruptions and to heal wounds by scar formation. However, studies of its potential anti-inflammatory effects have not been performed. The aim of the present study was to determine the anti-inflammatory OPEN ACCESSMolecules 2014, 19 10262 effect of extracts from the leaves of Senna villosa and to perform a bioassay-guided chemical study of the extract with major activity in a model of ear edema induced by 12-O-tetradecanoylphorbol 13-acetate (TPA). The results reveal that the chloroform extract from Senna villosa leaves has anti-inflammatory and anti-proliferative properties. Nine fractions were obtained from the bioassay-guided chemical study, including a white precipitate from fractions 2 and 3. Although none of the nine fractions presented anti-inflammatory activity, the white precipitate exhibited pharmacological activity. It was chemically characterized using mass spectrometry and infrared and nuclear magnetic resonance spectroscopy, resulting in a mixture of three aliphatic esters, which were identified as the principal constituents: hexyl tetradecanoate (C 20 H 40 O 2 ), heptyl tetradecanoate (C 21 H 42 O 2 ) and octyl tetradecanoate (C 22 H 44 O 2 ). This research provides, for the first time, evidence of the anti-inflammatory and anti-proliferative properties of compounds isolated from Senna villosa.

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“…Hyun et al [170] extracted emodin, alaternin, gluco-aurantioobtusin, glucoobtusifolin, cassiaside, cassitoroside, chrysophanol triglucoside, toralactone gentiobioside, questin, and 2-hydroxyemodin 1methylether from the methanol extract. Jimenez-Coello et al [171] isolated (8-hydroxymethylen)-trieicosanyl acetate from the Senna villosa (Mill.) H.S.Irwin & Barneby.…”

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confidence: 99%

A Review of Recent Studies on the Antioxidant and Anti-Infectious Properties of Senna Plants

Alshehri

Quispe

Herrera‐Bravo

et al. 2022

Oxidative Medicine and Cellular Longevity

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The use of phytochemicals is gaining interest for the treatment of metabolic syndromes over the synthetic formulation of drugs. Senna is evolving as one of the important plants which have been vastly studied for its beneficial effects. Various parts of Senna species including the root, stem, leaves, and flower are found rich in numerous phytochemicals. In vitro, in vivo, and clinical experiments established that extracts from Senna plants have diverse beneficial effects by acting as a strong antioxidant and antimicrobial agent. In this review, Senna genus is comprehensively discussed in terms of its botanical characteristics, traditional use, geographic presence, and phytochemical profile. The bioactive compound richness contributes to the biological activity of Senna plant extracts. The review emphasizes on the in vivo and in vitro antioxidant and anti-infectious properties of the Senna plant. Preclinical studies confirmed the beneficial effects of the Senna plant extracts and its bioactive components in regard to the health-promoting activities. The safety, side effects, and therapeutic limitations of the Senna plant are also discussed in this review. Additional research is necessary to utilize the phenolic compounds towards its use as an alternative to pharmacological treatments and even as an ingredient in functional foods.

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Anti-trypanosomal activity of (8-hydroxymethylen)-trieicosanyl acetate against infective forms of Trypanosoma cruzi

Cited by 8 publications

References 27 publications

Review on Experimental Treatment Strategies Against Trypanosoma cruzi

Review on Experimental Treatment Strategies Against Trypanosoma cruzi

Bioassay-Guided Chemical Study of the Anti-Inflammatory Effect of Senna villosa (Miller) H.S. Irwin & Barneby (Leguminosae) in TPA-Induced Ear Edema

A Review of Recent Studies on the Antioxidant and Anti-Infectious Properties of Senna Plants

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