Anti-Toxoplasma Effects of Methanol Extracts of Feijoa sellowiana, Quercus castaneifolia, and Allium paradoxum

Ebrahimzadeh, Mohammad Ali; Taheri, Mohammad Mohammad; Ahmadpour, Ehsan; Montazeri, Mahbobeh; Sarvi, Shahabeddin; Akbari, Mohammad Esmail; Daryani, Ahmad

doi:10.3831/kpi.2017.20.026

Cited by 22 publications

(5 citation statements)

References 27 publications

(34 reference statements)

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“…The fruit extract containing 100 g of the dried plant with 300 ml of methanol was prepared based on our recently published paper (Ebrahimzadeh et al, 2017). The next day, methanol was separated and a new solvent was added again.…”

Section: Drugs and Chemicalsmentioning

confidence: 99%

Protective effect of Feijoa sellowianan fruit on testicular toxicity‐induced by cadmium chloride

et al. 2020

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Cadmium chloride (CdCl 2) as an environmental and industrial toxin has a significant detrimental effect on the testis (Nna et al., 2017). CdCl 2 is in the heavy metal group that is primarily released from colour pigments, TV screens, plating, battery manufacturing, plastics and fertilisers, and mining activities (Saini & Dhania, 2020). This combination enters the human body through contaminated food, drinking water and inhalation of air containing CdCl 2 particles or smoke containing CdCl 2 due to occupational exposure or air pollution caused by jungle fire (Rehman et al., 2018). Also, nutrition is the main source of absorption of CdCl 2. Vegetables and grains that grow in CdCl 2-contaminated soils or soils that are naturally high in CdCl 2 to be the main source of nonworking conditions exposure (Chunhabundit, 2016). Tobacco plants selectively absorb CdCl 2 from the soil and tobacco consumption increases the level of CdCl 2 in the human body. CdCl 2 can enter the lungs through tobacco smoke (Ganguly et al., 2018) and then circulate CdCl 2 throughout the body. In the liver, CdCl 2 with proteins forms a complex that is eventually secreted by the kidneys (Shirriff & Heikkila, 2017). CdCl 2 concentration in the blood of smokers is 4-5 times and in kidney 2-3 times higher than nonsmokers (Mannino et al., 2004; Mazur et al., 2018). The half-life of cadmium in the blood is estimated at 75-128 days, which means that CdCl 2 is deposited in organs including the liver, kidney and reproductive system and is not excreted from the body (Thompson & Bannigan, 2008). CdCl 2 causes hepatotoxicity (Almeer et al., 2018), nephrotoxicity (Sadek et al., 2017) hematotoxicity (Pagano et al., 2017), cardiotoxicity (Shrivastava et al., 2019) and skeletal muscle injury (Al-Sawafi et al., 2017). Epidemiological studies have shown that CdCl 2 has negative effects on sex hormone concentrations, sperm parameters and male infertility (Olaniyan et al., 2018). Cd with rupture

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Section: Drugs and Chemicalsmentioning

confidence: 99%

Protective effect of Feijoa sellowianan fruit on testicular toxicity‐induced by cadmium chloride

et al. 2020

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“…Our findings demonstrated an increasing trend in cell proliferation until day 4 th . The increasing trend in proliferation of hBMSCs during the first 4 days of our study can be related to antioxidant, anti-inflammatory and modulating activities of the Feijoa (4,11,19,20) due to presence of several essential minerals, vitamins, phenolic acids, and polyphenols in the fruit (6). These properties made the fruit to have nutritional value to protect human red blood cells from mercury-induced cellular toxicity (21).…”

Section: Discussionmentioning

confidence: 78%

Screening of Feijoa (Acca Sellowiana (O. Berg) Burret) Fruit Effect on Proliferation and Apoptosis using Bone Marrow derived Stem Cells Model

et al. 2020

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Background and Objective: Curative properties of Feijoa sellowiana Bert. (Myrtaceae, Acca sellowiana), have been often claimed, while investigations into details of its bioactivities are still lacking. This study investigated the effect of acetonic extract of Feijoa (Acca sellowiana (O. Berg) Burret) fruit on proliferation and apoptosis of bone marrow derived stem cells. Methodology: Human bone marrow stem cells (hBMSCs) were characterized before experiments. MTT Assay was performed to determine the toxicity of Feijoa. The growth kinetics was also investigated until 7 days. Real time PCR assessed the expression of apoptosis genes. Results: In MTT assay, Feijoa at doses ≤ 5 ng/ml did not show any cytotoxic effect on hBMSCs and increased the cell proliferation until day 4 th followed by a decrease until day 7 th. Population doubling time (PDT) decreased until day 4 th followed by an increase until day 7 th. A significant increase in expression of Bax and decrease Bcl-2 expression were recorded on day 7 th. Conclusion: The antioxidant, anti-inflammatory and modulatory activities of Feijoa can explain the increasing effect on cell proliferation till day 4 th , but the apoptotic activity of Feijoa noted after four days is reported for the first time denoting to the short term antioxidant, anti-inflammatory and modulatory properties of Feijoa that should be considered for curative activity of this fruit.

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“…For in vivo determination of anti‐ Toxoplasma activity, 60 female Balb/c mice between 4 and 6 weeks of age were used. The animals received an intraperitoneal (IP) injection of T. gondii RH (2 × 10 4 tachyzoites) and then divided into 6 groups of 10 mice (Ebrahimzadeh et al., 2017). After inoculation, batch treatment was immediately started and continued for 5 days at regular 24‐hr intervals as follows: essential oil (200, 100, and 50 mg/kg‐1/day‐1), pyrimethamine (25 mg/kg‐1/day‐1), PBS (negative control), and sulfadiazine (500 mg kg −1 day −1 ) (positive control).…”

Section: Methodsmentioning

confidence: 99%

In vitro and in vivo Anti‐Toxoplasma activity of Dracocephalum kotschyi essential oil

Khamesipour

Razavi

Hejazi‬

et al. 2020

Food Science & Nutrition

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Toxoplasma gondii is a zoonotic parasite of worldwide importance, responsible for toxoplasmosis in homeotherms. Although treatment options are readily available, most drugs often cause serious side effects. Extracts of Dracocephalum kotschyi (D. kotschyi) have shown significant pharmacological activity against various parasites, viruses, and bacteria. In this study, we evaluated the anti‐T. gondii activity in vitro and in vivo of D. kotschyi essential oil. The thiazolyl blue tetrazolium bromide (MTT) method was used to assess the anti‐T. gondii activity and cytotoxicity of the essential oil. The presence of T. gondii was observed by Giemsa staining, and the viability was evaluated by the trypan blue staining method. Furthermore, the survival rate of acutely infected mice was evaluated by intraperitoneal injecting of the essential oil (50, 100, and 200 mg kg−1 day−1) for five days after infection with 2 × 104 tachyzoites. Essential oil, negative, and positive controls that showed the best toxoplasmacidal activity were assayed in triplicate at each concentration. The essential oil exhibited the highest anti‐Toxoplasma activity with a half‐maximal inhibitory concentration (IC50) of 9.94 ± 0.38 µg, with a selectivity index of 2.463. On Vero cells, the CC50 of the oil was 24.49 ± 0.96 µg and exhibited a significant anti‐Toxoplasma activity. Moreover, the treatment by essential oil significantly increased the survival rate compared to untreated infected control. In conclusion, the essential oil might be a useful compound, and with more testing, it may be an excellent alternative to standard chemical drugs in the treatment of toxoplasmosis.

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Anti-Toxoplasma Effects of Methanol Extracts of Feijoa sellowiana, Quercus castaneifolia, and Allium paradoxum

Cited by 22 publications

References 27 publications

Protective effect of Feijoa sellowianan fruit on testicular toxicity‐induced by cadmium chloride

Protective effect of Feijoa sellowianan fruit on testicular toxicity‐induced by cadmium chloride

Screening of Feijoa (<i>Acca Sellowiana</i> (<i>O. Berg</i>) <i>Burret</i>) Fruit Effect on Proliferation and Apoptosis using Bone Marrow derived Stem Cells Model

In vitro and in vivo Anti‐Toxoplasma activity of Dracocephalum kotschyi essential oil

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