Anti-Toxocara spp. antibodies in an adult healthy population: serosurvey and risk factors in Southeast Brazil

Negri, Elaine Cristina; Santarém, Vamilton Álvares; Rubinsky-Elefant, Guita; Giuffrida, Rogério

doi:10.1016/s2221-1691(13)60052-0

Cited by 35 publications

(29 citation statements)

References 32 publications

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“…among professionals and students who handle infective forms of the nematode T. canis. The overall prevalence rate in the entire study population was 14.9% (11/74), which was similar to that recorded in adults in Goiania (14.7%), 23 greater than that observed in São Paulo (8.7%) 5 and less than that observed in Salvador (46.3%). 4 It is worth emphasizing that prevalence rates vary according to the region and population studied.…”

Section: Discussionsupporting

confidence: 78%

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Human Toxocariasis: Prevalence and Factors Associated with Biosafety in Research Laboratories

Mattos

Santos

Telmo

et al. 2016

The American Society of Tropical Medicine and Hygiene

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Abstract. Human toxocariasis is a neglected parasitic disease worldwide. Researchers studying this disease use infectious strains of Toxocara for experiments. Health workers are at risk in the course of their daily routine and must adhere to biosafety standards while carrying out the activities. Researchers on biosafety concerning working with these parasites are insufficient. The aim of this study was to determine the rate of seroprevalence of Toxocara species among health-care research laboratory workers (professors, technicians, and students), and to investigate the risk factors of Toxocara infection associated with laboratory practices. This cross-sectional study involved 74 researchers at two federal universities in southern Brazil from February 2014 to February 2015; 29 researchers manipulated infective strains of Toxocara canis (test group) and 45 did not (control group). Serum samples were examined using enzymelinked immunosorbent assay. Epidemiological data were obtained via a questionnaire containing information about laboratory routine, eating behavior, and contact with dogs. The seroprevalence of anti-T. canis IgG was 14.9% (11/74; 13.8% [4/29] in the test group and 15.6% [7/45] in the control group). Most individuals in the test group correctly understood the primary mode of infection; however, 13.8% did not use gloves while manipulating T. canis eggs. Knowledge of biosafety must be well understood by health-care professionals doing laboratory work with biological agents. To our knowledge, this is the first study to investigate the rate of seroprevalence of IgG against Toxocara spp. among professionals and students who handle infective forms of the nematode T. canis.

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Section: Discussionsupporting

confidence: 78%

“…in the adult population range from 8.7% to 46.3%. 4,5 The nematode Toxocara canis, an intestinal parasite of dogs, is the etiological agent most associated with toxocariasis. 2 In recent decades, there has been an increase in researchers related to the diagnosis and control of this disease.…”

Section: Introductionmentioning

confidence: 99%

Human Toxocariasis: Prevalence and Factors Associated with Biosafety in Research Laboratories

Mattos

Santos

Telmo

et al. 2016

The American Society of Tropical Medicine and Hygiene

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“…As a result, eggs of T. canis are frequently detected in areas where dogs defecate. Nowadays, toxocariasis is a recognized public health problem in the adult population (Deutz et al 2005;Negri et al 2013;Poeppl et al 2013). Young children, however, are at higher risk of contracting the disease, due to their play habits and a tendency to put the hands in the mouth.…”

Section: Introductionmentioning

confidence: 99%

Environmental contamination with Toxocara eggs and seroprevalence of toxocariasis in children of northeastern Poland

et al. 2015

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Toxocariasis is a worldwide distributed zoonotic disease. Soil contaminated with Toxocara eggs appears to be the main source of infection for humans. The aim of our study was to estimate the environmental contamination with Toxocara eggs in public areas in northeastern Poland followed by the assessment of seroprevalence of toxocariasis in the children's population inhabiting the areas. A total of 168 soil samples were collected in June and September from public areas, and 28 from patients' residences. They were all examined for Toxocara eggs using the centrifugal flotation technique. Two-step serological tests comprising enzyme-linked immunosorbent assay (ELISA) and Western blot (WB) were performed in 190 children aged 2-17 without any symptoms of toxocariasis. The positive samples accounted for 36 and 32 % in the urban area, 39 and 18 % in the suburbs, and 39 and 46 % in parks, for June and September, respectively. All the sites located near the patients' residences with confirmed persistent toxocariasis were found contaminated with Toxocara eggs. A significant drop in the mean number of eggs was noted in the suburbs after summer (0.64 vs 0.18, p < 0.05). High and constant contamination was documented in soil from urban sandboxes and parks. The overall seroprevalence in children tested for toxocariasis was 4.2 % as determined by ELISA and WB (3.0 % in preschool children and 7.7 % in school children). The current study revealed high contamination of public areas in northeastern Poland with Toxocara eggs as well as marked seroprevalence in asymptomatic children. There is an urgent need to introduce and promote preventive health measures to limit spread of toxocariasis.

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“…10,[24][25][26][27][28][29][31][32][33][34][36][37][38][39][40][41][42][43][44] One study did not describe the diagnostic methodology applied. 35 As T. canis and T. cati cannot be distinguished serologically, we identified the study population as having toxocariasis.…”

Section: Resultsmentioning

confidence: 99%

A Systematic Review of Toxocariasis: A Neglected But High-Prevalence Disease in Brazil

Fialho¹,

Corrêa²

2016

The American Society of Tropical Medicine and Hygiene

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Abstract. Toxocariasis is an anthropozoonosis that occurs in all parts of the world. In particular, this disease can often be found in developing countries and in regions, where basic sanitation conditions are poor. However, industrialized countries have reported seroprevalence rates as high as 14.2% in humans. The definitive hosts of the disease are dogs and cats, whereas humans are a paratenic host. To determine the burden of toxocariasis in Brazil, we followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines to conduct a systematic review of the literature. Using keywords and applying the established criteria, we identified 160 publications and selected 22 articles for further analysis. The seroprevalence of toxocariasis in various regions of the country ranged from 4.2% to 65.4%. The highest prevalence was found in the northeast region, although the majority of the studies identified were from the southeast region. The findings suggest the importance of raising awareness among health professionals and public authorities about the fact that toxocariasis is a health problem.

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Anti-Toxocara spp. antibodies in an adult healthy population: serosurvey and risk factors in Southeast Brazil

Cited by 35 publications

References 32 publications

Human Toxocariasis: Prevalence and Factors Associated with Biosafety in Research Laboratories

Human Toxocariasis: Prevalence and Factors Associated with Biosafety in Research Laboratories

Environmental contamination with Toxocara eggs and seroprevalence of toxocariasis in children of northeastern Poland

A Systematic Review of Toxocariasis: A Neglected But High-Prevalence Disease in Brazil

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