Anti-thyroidal peroxidase antibodies are associated with thyrotropin levels in hypothyroid patients and in euthyroid individuals

Abstract

Objective. The study was designed to evaluate the relationship between thyroid antibodies and gland dysfunction, with the aim of finding a clinically useful threshold value of thyreoperoxidase antibodies, which could prove to be predictive for thyroid failure. Materials and method. The study was conducted on 99 women, ages ranging from 18-91 years (mean age: 45.5 ±17.0), were treated as outpatients in the Department of Endocrinology, Metabolism and Internal Medicine. Analysis of serum samples for TSH concentration and anti-TPO titers was conducted. Results. The most common disorder was hypothyroidism. Anti-TPO titers above reference range values were observed in 35 patients (35.4%): 21 (60%) were hypothyroid and 11 (31.4 %) were euthyroid. The anti-TPO and TSH serum levels correlated both in patients with high thyroid antibody titers, and in the anti-TPO negative groups. To find the threshold value of anti-TPO that would help predict hypothyroidism, receiver operating curves were used. With this approach, TPO antibody titers over 17 IU/ml indicated hypothyroidism with a 90% sensitivity and 75% sensibility. Conclusion. It can be postulated that the cutoff values of anti-TPO in the general population should be decreased in order to improve autoimmune thyroid disorder screening. Obviously, using that margin may lead initially to the detection of some false positive subjects. However, with lower cut-off values, more patients can be enrolled into thyroid follow-up groups. In this way, many people could avoid complications of undiagnosed, insidious thyroid failure.

Subclinical Hypothyroidism in Families Due to the Chronic Consumption of Nitrate-contaminated Water in Rural Areas of Durango, Mexico.

“…This is accompanied by the presence of anti-thyroid antibodies, mainly TPO and anti-thyroglobulin antibodies, which are considered biomarkers of thyroid gland damage (Radetti 2014). In contrast with the 60% established by Bromińska et al (2017) and Malathi et al (2013) and the 50% established by Jayashankar et al (2015), the present study found an SCH level of 15.7% in the presence of TPO-Ab (> 35 UI/ml). Therefore, autoimmune disorders would not be the main cause of SCH in the families of the study population.…”

Thyroid Hormones and Autoantibodies in Iraqi Hyperthyroid Patients

“…In contrast, Fawzi et al [17] found that T3, T4 and TSH are recorded a high significant difference between healthy and hyperthyroidism patients. On the other hand, our results seem to agree with those obtained by Nadhaif et al [18] who found significant differences in TPO antibodies levels between healthy and hyperthyroidism patients. Other studies found a slight increase in TPO antibodies level in hyperthyroidism patients [18].…”

Thyroid dysfunction and autoantibodies among patients infected with Covid 19 in Erbil city /IRAQ

“…Regarding gender association Anti TPO Ab was found among (71) females while only six male cases found to be Anti TPO Ab positive with significant differences (p value 0.032). and this were in agreement with a study done by Bromińska, et al 19 In our study; we found that Anti-TSH receptor Ab was higher among hyperthyroid cases which was positive in (18 from a total 21 cases 86%) with significant differences (p value 0.019). and this result was agreed by (Mistry et al).…”