Anti-Thyroid Peroxidase Antibodies in Thyroid Disorders and Non-Thyroid Autoimmune Diseases

Feldt‐Rasmussen, Ulla; Høier‐Madsen, Mimi; Bech, K; Blichert-Toft, M; Bliddal, Henning; Date, J.; Danneskiold‐Samsøe, Bente; Hegedűs, László; Hippe, Erik; Hornnes, Peter; Kriegbaum, N. J.; Müller, Klaus; Perrild, Hans; Rasmussen, Nini; Rasmusson, Bente; Schouboe, A.

doi:10.3109/08916939109007650

Cited by 73 publications

(39 citation statements)

References 13 publications

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“…Another possibility could be that the lower prevalence of subclinical hypothyroidism in smokers is secondary to the lower prevalence of thyroid autoantibodies. The present study does not directly support this hypothesis as one would expect a stronger association between smoking and TPO-Ab, which has been shown in several studies to correlate better to impaired thyroid function than Tg-Ab (31,37).…”

Section: Gender and Age (Years)contrasting

confidence: 93%

“…The major cause for spontaneous overt hypothyroidism is an autoimmune destruction of the thyroid gland (29). Nearly all patients with newly diagnosed overt hypothyroidism are TPO-Ab-and/or Tg-Ab-positive with TPO-Ab being more common than Tg-Ab (30)(31)(32). Only a modest correlation between the two antibodies has been found and it has been suggested that it is more or less random which antibody is produced (30).…”

Section: Gender and Age (Years)mentioning

confidence: 99%

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Smoking is negatively associated with the presence of thyroglobulin autoantibody and to a lesser degree with thyroid peroxidase autoantibody in serum: a population study

Pedersen¹,

Laurberg²,

Knudsen³

et al. 2008

European Journal of Endocrinology

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Background: Autoimmune thyroid diseases are common and the prevalence of circulating thyroid antibodies (thyroid peroxidase antibody, TPO-Ab and thyroglobulin antibody, Tg-Ab) is high in the population. The knowledge of a possible association between lifestyle factors and circulating thyroid antibodies is limited. Aim: To evaluate the correlation between smoking habits and the presence of circulating TPO-Ab and Tg-Ab. Material and methods: In a cross-sectional comparative population study performed in two areas of Denmark with moderate and mild iodine deficiency, 4649 randomly selected subjects from the population in some predefined age groups between 18 and 65 years were examined. Blood tests were analysed for TPO-Ab and Tg-Ab using assays based on the RIA technique. The participants answered questionnaires, were clinically examined and blood and urine samples collected. Results: Data were analysed in multivariate logistic regression models. There was a negative association between smoking and the presence of thyroid autoantibodies in serum. This association was observed for the presence of TPO-Ab and/or Tg-Ab, TPO-Ab (without respect to Tg-Ab status), Tg-Ab (without respect to TPO-Ab status) and both antibodies together. The association between smoking and thyroid autoantibodies was stronger for Tg-Ab than for TPO-Ab. There was no association between smoking and TPO-Ab measured alone or between smoking and TPO-Ab when Tg-Ab was included in the model as an explanatory variable. Conclusion: Smoking was negatively associated with the presence of thyroid autoantibodies with the strongest association between smoking and Tg-Ab. The study design precludes any conclusions as to the cause of the negative association between smoking thyroid autoantibodies.

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Section: Gender and Age (Years)contrasting

confidence: 93%

Section: Gender and Age (Years)mentioning

confidence: 99%

Smoking is negatively associated with the presence of thyroglobulin autoantibody and to a lesser degree with thyroid peroxidase autoantibody in serum: a population study

Pedersen¹,

Laurberg²,

Knudsen³

et al. 2008

European Journal of Endocrinology

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“…It has been questioned whether Tgab provides further diagnostic information compared with the single use of TPOab (or Micab) in the diagnosis of autoimmune thyroid disease (1,8,23). In our study Tab were with equal frequency directed against Tg and TPO with 14 of 17 of antibody-positive patients having Tgab and 13 of 17 having TPOab.…”

Section: Discussionmentioning

confidence: 91%

“…The Tab detected in previous studies have primarily been against thyroglobulin (Tgab) and microsomal antigens (Micab). It is now possible to measure the more sensitive and antigen-specific anti-thyroid peroxidase antibodies (TPOab) (8,9). However, Tab in serum do not always appear in autoimmune thyroid diseases (10).…”

Section: Introductionmentioning

confidence: 99%

Thyroid function, morphology and autoimmunity in young patients with insulin-dependent diabetes mellitus

Hansen

Bennedbæk²,

Hansen³

et al. 1999

European Journal of Endocrinology

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Objective: An association between insulin-dependent diabetes mellitus (IDDM) and autoimmune thyroid disease is well recognized. We have studied the prevalence of thyroid dysfunction, autoimmunity and morphological abnormalities by ultrasonography in young diabetics. Subjects and methods: Among young IDDM patients less than 18 years old and living in the county of Funen, Denmark, 105 of 116 eligible patients participated. They were compared with 105 healthy children matched for sex and age. Routine thyroid function parameters (thyroxine (T 4 ), tri-iodothyronine (T 3 ), T 3 resin uptake and TSH) and thyroid autoantibodies (anti-thyroid peroxidase, TPOab, and thyroglobulin antibodies, Tgab) were measured. Thyroid size and morphology were determined by ultrasonography. Results: Two of the diabetics had previously diagnosed hypothyroidism and three new cases of subclinical hypothyroidism were found.

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“…An elevated level of antibodies to TPO (TPOab) was reported to be the major risk factor for AITD (16). With sensitive assay techniques, 95% of the patients with hypothyroidism (Hashimoto's thyroiditis) and 85% of those with hyperthyroidism (Graves' disease) have detectable levels of TPOab (17).…”

Section: Introductionmentioning

confidence: 99%

Antithyroid peroxidase antibody positivity is associated with lower incidence of metastasis in breast cancer

Kemal

Demirağ

Ekiz

et al. 2015

Molecular and Clinical Oncology

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Abstract. Thyroid extracts were first used to treat patients with metastatic breast cancer over a century ago. Since then, a number of studies have investigated the association between thyroid disorders and breast cancer. The presence of antibodies to thyroid peroxidase (TPOab) was recently reported to be associated with improved outcome in these patients. The aim of the present study was to evaluate the association between TPOab positivity and clinicopathological characteristics in breast cancer patients. The study included 318 newly diagnosed cases of breast cancer treated at Ondokuz Mayis University Hospital, Samsun, Turkey, between 2008 and 2012. Serum thyroid-stimulating hormone, free triiodothyronine and free thyroxine levels were measured at the time of diagnosis. Of the 318 patients, 253 were considered to be TPOab-negative (TPOab ≤34 IU/ml) and 65 TPOab-positive (TPOab >34 IU/ml). No cases with distant metastases were found in the TPOab-positive group. However, 20 (7.9%) of the 253 patients displayed distant metastases in the TPOab-negative group (P=0.01). Therefore, TPOab positivity was found to be associated with a lower incidence of metastasis in breast cancer patients.

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Anti-Thyroid Peroxidase Antibodies in Thyroid Disorders and Non-Thyroid Autoimmune Diseases

Cited by 73 publications

References 13 publications

Smoking is negatively associated with the presence of thyroglobulin autoantibody and to a lesser degree with thyroid peroxidase autoantibody in serum: a population study

Smoking is negatively associated with the presence of thyroglobulin autoantibody and to a lesser degree with thyroid peroxidase autoantibody in serum: a population study

Thyroid function, morphology and autoimmunity in young patients with insulin-dependent diabetes mellitus

Antithyroid peroxidase antibody positivity is associated with lower incidence of metastasis in breast cancer

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