Anti-thrombotic effect of rutin isolated from Dendropanax morbifera Leveille

Choi, Jong-In; Kim, Dae‐Won; Park, Se-Eun; Lee, Hyo‐Jeong; Kim, Ki-Man; Kim, Kyung-Je; Kim, Myung-Kon; Kim, Sungjun; Kim, Seung

doi:10.1016/j.jbiosc.2014.12.012

Cited by 75 publications

(56 citation statements)

References 27 publications

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“…9,10 In this regard, D. morbifera leaves and stems have been used in oriental medicine in Korea and People's Republic of China and have been reported to have beneficial effects in numerous diseases. 7,17,18 In this study, D. morbifera leaves were used for the first time for the green synthesis of D-AgNPs and D-AuNPs, which were further studied for their in vitro anticancer efficacies.…”

Section: Resultsmentioning

confidence: 99%

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Rapid green synthesis of silver and gold nanoparticles using Dendropanax morbifera leaf extract and their anticancer activities

Kim¹,

Wang²,

Mathiyalagan³

et al. 2016

IJN

109

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Dendropanax morbifera Léveille is an oriental medicinal plant that is traditionally used in folk medicine and grows in a specific region of South Korea. We aimed to enhance the utilization of D. morbifera medicinal plants for synthesis of silver nanoparticles (AgNPs) and gold nanoparticles (AuNPs). D. morbifera leaf extract acted as both a reducing and a stabilizing agent that rapidly synthesized Dendropanax AgNPs (D-AgNPs) and Dendropanax AuNPs (D-AuNPs). The D-AgNPs and D-AuNPs were characterized by ultraviolet-visible spectroscopy, energy dispersive X-ray analysis, elemental mapping, field emission transmission electron microscopy, X-ray diffraction, and dynamic light scattering. The characterizations revealed that the D-AgNPs and D-AuNPs were in polygon and hexagon shapes with average sizes of 100–150 nm and 10–20 nm, respectively. The important outcomes were the synthesis of AgNPs and AuNPs within 1 hour and 3 minutes, respectively, avoiding the subsequent processing for removal of any toxic components or for stabilizing the nanoparticles. Additionally, D-AgNPs and D-AuNPs were examined for cytotoxicity in a human keratinocyte cell line and in A549 human lung cancer cell line. The results indicated that D-AgNPs exhibited less cytotoxicity in the human keratinocyte cell line at 100 µg/mL after 48 hours. On the other hand, D-AgNPs showed potent cytotoxicity in the lung cancer cells at the same concentration after 48 hours, whereas D-AuNPs did not exhibit cytotoxicity in both cell lines at the same concentration. However, both D-AgNPs and D-AuNPs at 50 µg/mL enhanced the cytotoxicity of ginsenoside compound K at 25 µM after 48 hours of treatment compared with CK alone. We believe that this rapid green synthesis of D-AgNPs and D-AuNPs is a valuable addition to the applications of D. morbifera medicinal plant. D-AuNPs can be used as carriers for drug delivery and in cancer therapy due to their lack of normal cell cytotoxicity.

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Section: Resultsmentioning

confidence: 99%

“…For example, the bioflavonoid rutin demonstrates antithrombic and anticoagulant activities. 7 Although different medicinal plants have been reported for green synthesis of silver nanoparticles (AgNPs) and gold nanoparticles (AuNPs), 8,9 we utilized the leaf extract of D. morbifera to increase the utility of this plant.…”

Section: Introductionmentioning

confidence: 99%

Rapid green synthesis of silver and gold nanoparticles using Dendropanax morbifera leaf extract and their anticancer activities

Kim¹,

Wang²,

Mathiyalagan³

et al. 2016

IJN

109

View full text Add to dashboard Cite

show abstract

“…[14,15]. Recently, there has been increasing interest to isolate thrombolytic and antithrombotic agents from food and natural sources, which are presumed to be effective and safe [16]. In the present study, the antithrombosis effect of WCSW were studied, and it was proved to be safe by oral administration and possessed significant inhibitory effect on ADP, AA and collagen induced platelet aggregation in rat PRP.…”

Section: Discussionmentioning

confidence: 75%

Anti-thrombotic and anti-tumor effect of water extract of caulis of Sargentodoxa cuneata (Oliv) Rehd et Wils (Lardizabalaceae) in animal models

Chen¹,

Wan²,

Zhou³

2016

Trop. J. Pharm Res

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“…This set of detected flavonoids have been reported to possess some health benefits like antioxidant [38], antifungal and antileishmanial [39]. Kaempherol was reported by Choi et al, [40] to inhibits thrombosis and platelet activation while rutin isolated from Dendropanax morbifera L. was also discovered to have anti-thrombotic effect [41]. Furthermore, dietary flavonoids has also been implicated in the amelioration of cataract induced by sugar [42].…”

Section: Figure 5: Effects Of Curcuma Longa Extract On Zebrafish Larvmentioning

confidence: 99%

Phytochemical evaluation, Embryotoxicity and Teratogenic effects of Curcuma longa extract in Zebrafish (Danio rerio)

Alafiatayo

Song

Ahmad

et al. 2019

Preprint

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Curcuma longa L. is a rhizome plant often used as traditional medicinal preparations in Southeast Asia. The dried powder is commonly known as cure-all herbal medicine with a wider spectrum of pharmaceutical activities. In spite of the widely reported therapeutic applications of C. longa, research on its safety and teratogenic effects on zebrafish embryos and larvae is still limited. Hence, this research was aimed to assess the toxicity of C. longa extract on zebrafish. Using a reflux flask, methanol extract of C. longa was extracted and the identification and quantification of total flavonoids were carried out with HPLC. Twelve fertilized embryos were selected to test the embryotoxicity and teratogenicity at different concentration points. The embryos were exposed to the extract in the E3M medium while the control was only exposed to E3M and different developmental endpoints were recorded with the therapeutic index calculated using the ratio of LC50/EC50. C. longa extract was detected to be highly rich in flavonoids with catechin, epicatechin and naringenin as the 3 most abundant with concentrations of 3,531.34, 688.70 and 523.83μg/mL respectively. The toxicity effects were discovered to be dose-dependent at dosage above 62.50μg/mL, while at 125.0μg/mL, mortality of embryos was observed and physical body deformities of larvae was recorded among the hatched embryos at higher concentrations. Teratogenic effect of the extract was severe at higher concentrations producing physical body deformities such as kink tail, bend trunk, enlarged yolk sac edema. Finally, the Therapeutic Index (TI) values calculated were approximately same for different concentration points tested. Overall, the result revealed that plants having therapeutic potential could also pose threats when consumed at higher doses especially on the embryos. Therefore, detailed toxicity analysis should be carried out on medicinal plants to ascertain their safety on the embryos and its development. Abbreviations:DMSO, dimethyl sulfoxide; HPLC, high performance liquid chromatography; OECD, organisation for economic cooperation and development; FET, fish embryo acute toxicity test; hpf, hour of post fertilization.

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Anti-thrombotic effect of rutin isolated from Dendropanax morbifera Leveille

Cited by 75 publications

References 27 publications

Rapid green synthesis of silver and gold nanoparticles using<em> Dendropanax morbifera</em> leaf extract and their anticancer activities

Rapid green synthesis of silver and gold nanoparticles using<em> Dendropanax morbifera</em> leaf extract and their anticancer activities

Anti-thrombotic and anti-tumor effect of water extract of caulis of <i>Sargentodoxa cuneata</i> (Oliv) Rehd et Wils (Lardizabalaceae) in animal models

Phytochemical evaluation, Embryotoxicity and Teratogenic effects of Curcuma longa extract in Zebrafish (Danio rerio)

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