Anti-Thrombotic, anti-platelet and fibrinolytic therapy: Current management of acute myocardial infarction

Helft, Gérard; Worthley, Stephen G.

doi:10.1046/j.1444-2892.2001.00086.x

Cited by 6 publications

(3 citation statements)

References 46 publications

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“…In addition to their role in clot formation, platelets are now recognized as important players in inflammatory processes, cancer, atherosclerosis, and vascular integrity, among other pathophysiological states [2,3]. Platelet function is tightly controlled as any disturbance may cause fatal bleeding or occlusion of blood vessels [4]. Platelets interact with the damaged vessel wall in a process that involves specific surface receptors that promote rolling and adhesion over the endothelium and the extracellular matrix.…”

Section: Introductionmentioning

confidence: 99%

Cbl proteins in platelet activation

et al. 2012

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Platelets play a fundamental role in hemostasis. Their functional responses have to be tightly controlled as any disturbance may lead to bleeding disorders or thrombosis. It is thus important to clearly identify and understand the signaling mechanisms involved in platelet function. An important role of c-Cbl and Cbl-b ubiquitin ligases in platelet functional responses and in hematological malignancies has been recently described. Cbl proteins perform negative and positive regulation of several signaling pathways in platelets. In this review, we explore the role of Cbl proteins in platelet functional responses.

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Section: Introductionmentioning

confidence: 99%

Cbl proteins in platelet activation

et al. 2012

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“…Blood platelets are implicated in the haemostatic process and also in thrombus formation, which is one of the important contributor to pathogenesis of many circulatory diseases and inflammatory conditions (Helf and Worthley, 2001;Rand et al, 2003;Savage et al, 2001;Steinhubl and Moliterno, 2005). Thus, anti-platelet compounds have wide therapeutic potential for various circulatory diseases.…”

Section: Introductionmentioning

confidence: 99%

Anti-platelet effects of flavonoids and flavonoid-glycosides from Sophora japonica

Kim

Yun‐Choi

2008

Arch. Pharm. Res.

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A methanol extract of Sophora japonica was subjected to anti-platelet activity guided fractionation affording the isolation of four flavonoids and six flavonoid-glycosides: biochanin A (1), irisolidone (2), genistein (3), sissotrin (4), sophorabioside (5), genistin (6), tectoridin (7), apigenin (8), quercitrin (9), and rutin (10). The structure of each compound was determined by a variety of spectroscopic methods. Among the compounds, 1, 3, and 7 showed approximately 2.5-6.5 fold greater inhibitory effects on arachidonic acid (AA) and U46619 induced platelet aggregation (IC50: 19.9 and 99.8 microM; 20.3 and 53.8 microM; 25.9 and 123.4 microM, respectively) than acetylsalicylic acid (ASA, IC50: 63.0 and 350.0 microM). Compound 2 was an approximately 22-40 fold stronger inhibitor than ASA on AA and U46619 induced aggregation (IC50: 1.6 and 15.6 microM, respectively).

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“…[16171819] Thus, anti-platelet compounds have wide therapeutic potential for various circulatory diseases.…”

Section: Introductionmentioning

confidence: 99%

ACE and platelet aggregation inhibitors from Tamarix hohenackeri Bunge (host plant of Herba Cistanches) growing in Xinjiang

Xing¹,

Liao²,

Tang³

et al. 2014

Phcog Mag

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Background:Tamarix hohenackeri Bunge is a salt cedar that grows widespread in the desert mountains in Xinjiang. T. hohenackeri has not been investigated earlier, although there are many reports of phytochemical work on other Tamarix species.Materials and Methods:To find out natural angiotensin-converting enzyme (ACE) inhibitor and platelet aggregation inhibitors, the bioactive extract (ethyl acetate [EtOAc] fraction) from the dried aerial parts of T. hohenackeri were investigated. The active fraction was purified by repeated column chromatography, including silica gel, Sephadex LH-20 column, medium-pressure liquid chromatography (MPLC) (polyamide column) and high-performance liquid chromatography (HPLC). The isolated major constituents were tested for their anti-platelet aggregation activity.Results:Bioassay-directed separation of the EtOAc fraction of the 70% ethanol extract from the air-dried aerial parts of T. hohenackeri led to the isolation of a new triterpenoid lactone (1), together with 13 known compounds (2-14). It was the first time to focus on screening bioactive constituents for this plant. The chemical structures were established on the basis of spectral data (ESI-MS and NMR). The results showed that the flavonoid compounds (7 and 8) and phenolic compounds (9, 10, 11, and 14) were potential ACE inhibitors. And the flavonoid compounds (5 and 7) showed significant anti-platelet aggregation activities.Conclusion:On the basis of the chemical and biological data, the material basis of ACE inhibitory activity for the active part was the phenolic constituents. However, the flavonoid compounds were responsible for the anti-platelet aggregation. The primary structure and activity relationship were also discussed respectively.

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Anti-Thrombotic, anti-platelet and fibrinolytic therapy: Current management of acute myocardial infarction

Cited by 6 publications

References 46 publications

Cbl proteins in platelet activation

Cbl proteins in platelet activation

Anti-platelet effects of flavonoids and flavonoid-glycosides from Sophora japonica

ACE and platelet aggregation inhibitors from Tamarix hohenackeri Bunge (host plant of Herba Cistanches) growing in Xinjiang

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