Anti-solvent crystallization of l-threonine in Taylor crystallizers and MSMPR crystallizer: Effect of fluid dynamic motions on crystal size, shape, and recovery

Process Intensification of Continuous Antisolvent Crystallization Using a Coiled Flow Inverter

“…Other researchers have observed a decrease in crystal size associated with the effectiveness of mixing. Lee et al used the Couette–Taylor (CT) crystallizer for the crystallization of l -threonine . They found that the size of the crystals was almost two times smaller than the l -threonine produced in a MSMPR crystallizer.…”

“…In 2017, Lee et al worked with the antisolvent crystallization of l -threonine in a CT crystallizer . They reported higher crystal recovery ratios and a better control of the crystal size and crystal morphology with the CT crystallizer when compared to the traditional MSMPR crystallizer.…”

Effect of Fluid Flow on Crystallization in a Segmented Flow Microchannel

“…is is commonly observed in a stirred tank where nucleation is promoted at a higher stirring rate (Lee et al, 2017). e strong shear in the segmented ow is considered to be advantageous for nucleation.…”

Development and characterisation of a cascade of moving baffle oscillatory crystallisers (CMBOC)

“…Therefore, it is not surprising that in the recent years increased research efforts have been made to develop and assess new crystallisers to achieve efficient process operation and enhanced particle control, these include mixed suspension mixed product removal (MSMPR) with single or multiple stages (cascade), plug flow reactors (PFRs) and Couette-Taylor crystallisers. [5][6][7][8][9][10][11][12] Also, well characterised experimental and digital design methodologies for process design, scale-up and optimisation of processes using these technologies have received considerable attention. 13 MSMPRs remain the most widely utilised platform for continuous crystallisation largely due to familiarity in terms of operation and control to existing batch equipment and these have been successfully operated at a range of scales from 1-10 L. 14 There are however, some recognised disadvantages of MSMPRs that include localised high shear near the impeller or agitator, non-uniform thermal control and nonlinear process scalability.…”

“…Manipulation of the Taylor vortex flow generated in the gap between two rotating co-axial cylinders has been used to effect control over the crystal size distribution, phase transformation, polymorphic form and agglomeration. 6 Another important consideration in the design of a crystalliser is its suitability for operating different crystallisation processes including antisolvent, cooling, combined antisolvent-cooling, reactive or pH controlled crystallisations. 15,30 Each crystallisation type requires means of control over particular process parameters.…”