Anti-sickling activities of two isolated compounds from the root of Combretum racemosum P. beauv. (Combretaceae)

Famojuro, Tayo I.; Adeyemi, Abiodun Adegoke; Ajayi, Temitayo O.; Fasola, F A; Fukushi, Yukiharu; Omotade, Olayemi O.; Moody, J. O.

doi:10.1016/j.jep.2021.113992

Cited by 3 publications

(1 citation statement)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The extract has an antisickling impact and a substantial membrane stabilizing (protective) effect. Another study conducted by Famojuro, Adeyemi, Ajayi, Fasola, Fukushi, Omotade, and Moody [ 77 ] reported that two isolated compounds from the root of Combretum racemosum P. beauv ( Combretaceae ) showed effective SCD management. These compounds are proved to trigger red cells’ membrane-bound enzymes Na + , K + -ATPase, and Ca 2+ -ATPase, which are engaged in the sickling process.…”

Section: Functional Food Exploited In Scd Managementmentioning

confidence: 99%

Sickle Cell Disease: Current Drug Treatments and Functional Foods with Therapeutic Potential

Gonçalves,

Smaoui,

Brito

et al. 2024

CIMB

View full text Add to dashboard Cite

Sickle cell anemia (SCA), the most common form of sickle cell disease (SCD), is a genetic blood disorder. Red blood cells break down prematurely, causing anemia and often blocking blood vessels, leading to chronic pain, organ damage, and increased infection risk. SCD arises from a single-nucleotide mutation in the β-globin gene, substituting glutamic acid with valine in the β-globin chain. This review examines treatments evaluated through randomized controlled trials for managing SCD, analyzes the potential of functional foods (dietary components with health benefits) as a complementary strategy, and explores the use of bioactive compounds as functional food ingredients. While randomized trials show promise for certain drugs, functional foods enriched with bioactive compounds also hold therapeutic potential. Further research is needed to confirm clinical efficacy, optimal dosages, and specific effects of these compounds on SCD, potentially offering a cost-effective and accessible approach to managing the disease.

show abstract

Section: Functional Food Exploited In Scd Managementmentioning

confidence: 99%