Anti-SARS-CoV-2 Activity of Surgical Masks Infused with Quaternary Ammonium Salts

Selwyn, Gary S.; Ye, Chunyan; Bradfute, Steven B.

doi:10.3390/v13060960

Cited by 9 publications

(7 citation statements)

References 12 publications

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“…In this regard, natural anti-SARS-CoV-2 products could limit the concerns about in vivo usage, which remain to be thoroughly studied in all such surface inhibitory applications. Selwyn and colleagues [ 33 ] showed SARS-CoV-2 inactivation after 5, 20, and 60 min using a combination of a natural citric acid with 3% thymol and 1297 quaternary ammonium compound which was infused in surgical masks.…”

Section: Resultsmentioning

confidence: 99%

Copper-Silver Nanohybrids: SARS-CoV-2 Inhibitory Surfaces

et al. 2021

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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains a severe health threat. The COVID-19 infections occurring in humans and animals render human-animal interfaces hot spots for spreading the pandemic. Lessons from the past point towards the antiviral properties of copper formulations; however, data showing the “contact-time limit” surface inhibitory efficacy of copper formulations to contain SARS-CoV-2 are limited. Here, we show the rapid inhibition of SARS-CoV-2 after only 1 and 5 min on two different surfaces containing copper-silver (Cu-Ag) nanohybrids. We characterized the nanohybrids’ powder and surfaces using a series of sophisticated microscopy tools, including transmission and scanning electron microscopes (TEM and SEM) and energy-dispersive X-ray spectroscopy (EDX). We used culturing methods to demonstrate that Cu-Ag nanohybrids with high amounts of Cu (~65 and 78 wt%) and lower amounts of Ag (~7 and 9 wt%) inhibited SARS-CoV-2 efficiently. Collectively, the present work reveals the rapid SARS-CoV-2 surface inhibition and the promising application of such surfaces to break the SARS-CoV-2 transmission chain. For example, such applications could be invaluable within a hospital or live-stock settings, or any public place with surfaces that people frequently touch (i.e., public transportation, shopping malls, elevators, and door handles) after the precise control of different parameters and toxicity evaluations.

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Section: Resultsmentioning

confidence: 99%

Copper-Silver Nanohybrids: SARS-CoV-2 Inhibitory Surfaces

et al. 2021

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“…[ 12 ] On the other hand, Selwyn et al manufactured a surgical mask infused with QAS to inactivate SARS‐CoV‐2 in a rapid and safe manner. [ 13 ] Also, Ikner et al proposed and evaluated a QAS polymer coating against SARS‐CoV‐2. [ 14 ]…”

Section: Introductionmentioning

confidence: 99%

“…[6][7][8] Quaternary ammonium salts (QAS) represent an accessible antiseptic with antiviral properties that could be used against SARS-CoV-2 due to their ability to form active bonds capable of breaking the protein capsid of different viruses and bacteria. [9][10][11][12][13][14] Ogilvie et al formulated different quaternary ammonium disinfectants, demonstrating that their formulations rapidly inactivate SARS-CoV-2, making them potentially useful for controlling SARS-CoV-2 spread in hospitals and the community. [12] On the other hand, Selwyn et al manufactured a surgical mask infused with QAS to inactivate SARS-CoV-2 in a rapid and safe manner.…”

Section: Introductionmentioning

confidence: 99%

“…[12] On the other hand, Selwyn et al manufactured a surgical mask infused with QAS to inactivate SARS-CoV-2 in a rapid and safe manner. [13] Also, Ikner et al proposed and evaluated a QAS polymer coating against SARS-CoV-2. [14] SARS-CoV-2 presence can be probed by detecting its RNA by real-time reverse transcription-polymerase chain reaction (RT-PCR) assays targeting the RNAdependent RNA polymerase (RdRp), spike (S), and nucleocapsid (N) genes of SARS-CoV-2.…”

Section: Introductionmentioning

confidence: 99%

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Antiviral capacity of polypropylene/(1‐Hexadecyl) trimethyl‐ammonium bromide composites against COVID‐19

Guerrero‐Bermea

Fuentes

Cervantes‐Uc

et al. 2022

Polymer Engineering & Sci

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During the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) pandemic, scientists from different areas are looking for alternatives to fight it. SARS‐CoV‐2, the cause of the infectious respiratory disease COVID‐19, is mainly transmitted through direct or indirect contact with infected respiratory droplets. The integrity of the virus structure is crucial for its viability to attack human cells. Quaternary ammonium salts are characterized by having antiviral capabilities which alter or destroy the structure of the viral capsid. In this work, polypropylene (PP)/(1‐Hexadecyl) trimethyl‐ammonium bromide (CTAB) composites have been prepared in order to create an antiviral material. The composites were melt processed and blown to produce thin films. The CTAB content on the antiviral effect was evaluated using antibodies and serum from infected patients with the SARS‐CoV‐2 virus. In addition, the mechanical and thermal properties of blown films were investigated, and CTAB release kinetics from the films was followed by UV–Vis. The results indicate that the virus tends to remain less on the polymer surface by increasing the amount of CTAB in the PP matrix.

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“…It was found that BACs could effectively inactivate 99% of SARS-CoV-2 particles in one minute of contact and methicillin-resistant Staphylococcus aureus and Staphylococcus epidermis ( Martí et al, 2021 , Tuñón-Molina et al, 2021 ), indicating their possible preventive use among healthcare workers and researchers. Surgical masks infused with QACs were also reported to inactivate a high dose of up to 1 × 10 5 pfu (plaque-forming units) of live SARS-CoV-2 within minutes ( Selwyn et al, 2021 ).…”

Section: Classification Mechanism Of Action and Applications Of Qacsmentioning

confidence: 99%

Quaternary ammonium compounds of emerging concern: Classification, occurrence, fate, toxicity and antimicrobial resistance

Mohapatra

Yutao

Goh

et al. 2023

Journal of Hazardous Materials

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Anti-SARS-CoV-2 Activity of Surgical Masks Infused with Quaternary Ammonium Salts

Cited by 9 publications

References 12 publications

Copper-Silver Nanohybrids: SARS-CoV-2 Inhibitory Surfaces

Copper-Silver Nanohybrids: SARS-CoV-2 Inhibitory Surfaces

Antiviral capacity of polypropylene/(1‐Hexadecyl) trimethyl‐ammonium bromide composites against COVID‐19

Quaternary ammonium compounds of emerging concern: Classification, occurrence, fate, toxicity and antimicrobial resistance

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