Anti- Saccharomyces cerevisiae Antibody in Intestinal Behçet's Disease Patients: Relation to Clinical Course

Choi, Chang Hwan; Kim, Tae Il; Kim, Jae Hak; Shin, Sung Jae; Lee, Sang Kil; Kim, Hyun Sook

doi:10.1007/s10350-006-0706-z

Cited by 50 publications

(27 citation statements)

References 41 publications

(43 reference statements)

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“…Hence, further prospective studies with international validation are needed, and histopathologic and laboratory tests specifi c for intestinal BD, such as HLA-B51 or ASCA (anti-Saccharomyces cerevisiae antibody), might be included in the next version of the criteria. In an anecdotal report, ASCA was reported to be associated with intestinal BD and patients with ASCA were more likely to receive surgical treatment (30) . Finally, because only patients with ulcerations…”

Section: Inflammatory Bowel Diseasementioning

confidence: 99%

Development and Validation of Novel Diagnostic Criteria for Intestinal Behçet's Disease in Korean Patients With Ileocolonic Ulcers

et al. 2009

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Section: Inflammatory Bowel Diseasementioning

confidence: 99%

Development and Validation of Novel Diagnostic Criteria for Intestinal Behçet's Disease in Korean Patients With Ileocolonic Ulcers

et al. 2009

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Section: Autoantibodiesmentioning

confidence: 99%

“…Among them the most described were anti-Saccharomyces cerevisiae antibodies (ASCAs) [198][199][200][201] and anti-endothelial cell antibodies (AECAs) [202][203][204][205]. ASCAs were linked more to gastrointestinal manifestations in BD [198][199][200][201][202] and their healthy relatives [201]. AECA has been implicated with vascular [202,204] and intestinal [205] involvement in BD and several studies demonstrated that alpha-enolase is the target antigen of AECA in BD patients [203][204][205].…”

Section: Autoantibodiesmentioning

confidence: 99%

Etiology, Immunopathogenesis and Biomarkers in Behçet’s disease

Adeeb¹,

Khan²,

Stack³

et al. 2017

Behcet's Disease

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Behçet's disease (BD) is a type of vasculitis with many distinctive clinical manifestations and multifactorial immunopathogenesis. The cause of BD remains unknown, but it has been postulated that in a genetically predisposed or susceptible population, exogenous agents trigger the dysregulation of both autoinflammatory and autoimmune responses resulting in multisystem vasculitis. There are robust ongoing efforts across the globe to elucidate and identify signature markers to improve and assist in rapid diagnosis of the disease and to tailor the best therapy accordingly. While association of human leukocyte antigen (HLA)-B * 51 (B * 51:01 subtype) allele is well recognized as the strongest genetic susceptibility gene so far among genetically predisposed BD patients, further investigations using the latest technology have led to the identification of several novel single nucleotide polymorphisms (SNPs) and other associated genes involved in the pathogenesis. There are several "established" cytokines known to be involved in the pathogenesis of BD, which have been further implicated in the genome-wide association studies (GWAS)-based cytokine/receptor gene loci studies, as well as numerous "novel" cytokines, which are currently being studied and identified. This chapter offers insights into current knowledge and thoughts regarding the future of biomarkers in BD.

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“…Fresko et al reassessed the level of IgG and IgA ASCA in 85 BD patients and found no significant difference between BD and group of diseased and healthy controls; however, there was a significant trend for patients with gastrointestinal (GI) involvement with BD to be more positive for ASCA compared with the rest of the patients with BD [141]. In another study, ASCA positive rate in BD, intestinal BD and healthy control subjects was shown to be 3.3%, 44.3%, and 8.8% respectively; however, clinical findings at diagnosis and cumulative relapse rates of intestinal BD were not found to be associated with ASCA expression [142]. There is also a report of a relatively high percentage of seropositivity for anti-S. cerevisiae Mannan antibody in patients with Crohn's disease and patients with BD compared with normal controls [143].…”

Section: Saccharomyces Cerevisiaementioning

confidence: 99%

Behcet’s disease: from heat shock proteins to infections

2014

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Background: Behcet's disease (BD) is a chronic, inflammatory multisystemic condition of unknown etiology. Although the cause of BD is not clear, it is believed to be the result of an autoimmune process triggered by an infectious or environmental agent (possibly local to a geographic region) in a genetically predisposed individual. Objective: To detail current knowledge of the role of microorganisms in the pathogenesis of BD and review the infectious etiology of this disease. Methods: The review based on publication in SCOPUS, Science direct, and PubMed. Results: A microbial infection has been implicated in the development of the disease to explain the strong inflammatory reactions observed, the activation of monocytes and macrophages, and the induction of proinflammatory cytokines and chemokines detected. Common factors linking some of the possible pathogenetic agents are extrinsically induced tissue stress or heat shock proteins, which react with host tissues and elicit significant T-helper type 1 cell responses. Conclusion: Based on collected data, we conclude that the microorganisms discussed seem to participate and, at least in part, act as triggers during the course of BD. By clarifying the microbial associations of BD and finding its etiology, particularly the causative antigens leading to BD, it would be easier to suggest more effective treatment and preventive strategies for this disease.

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Anti- Saccharomyces cerevisiae Antibody in Intestinal Behçet's Disease Patients: Relation to Clinical Course

Cited by 50 publications

References 41 publications

Development and Validation of Novel Diagnostic Criteria for Intestinal Behçet's Disease in Korean Patients With Ileocolonic Ulcers

Development and Validation of Novel Diagnostic Criteria for Intestinal Behçet's Disease in Korean Patients With Ileocolonic Ulcers

Etiology, Immunopathogenesis and Biomarkers in Behçet’s disease

Behcet’s disease: from heat shock proteins to infections

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