Anti‐rheumatic medication and salivary MMP‐8, a biomarker for periodontal disease

Äyräväinen, Leena; Heikkinen, Anna Maria; Kuuliala, Antti; Ahola, Kirsi; Koivuniemi, Riitta; Moilanen, Eeva; Hämäläinen, Mari; Tervahartiala, Taina; Meurman, Jukka H.; Leirisalo‐Repo, Marjatta; Sorsa, Timo

doi:10.1111/odi.12930

Cited by 17 publications

(30 citation statements)

References 37 publications

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“…The salivary levels of TIMP-1 significantly decreased after treatment in both groups. In line with our findings, the MMP-8/TIMP-1 axis ratio in saliva has been positively associated with the periodontal inflammatory burden index [ 43 ], which suggests that the reduction in salivary levels of the MMP-8/TIMP-1 axis reflected the inflammatory status of the disease. To date, no study has evaluated the impact of peri-implant treatment on TIMP-1 levels.…”

Section: Discussionsupporting

confidence: 89%

Peri-Implant Surgical Treatment Downregulates the Expression of sTREM-1 and MMP-8 in Patients with Peri-Implantitis: A Prospective Study

Neves

Elangovan

Teixeira

et al. 2022

IJERPH

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sTREM-1 and its ligand PGLYRP1 play an essential role in the inflammatory process around teeth and implants. In this study, we aimed to evaluate the impact of peri-implant treatment on the salivary levels of the sTREM-1/PGLYRP-1/MMP-8 axis after 3 months. A total of 42 participants (with a mean age of 61 years old ± 7.3) were enrolled in this longitudinal study, 24 having peri-implant mucositis (MU) and 18 having peri-implantitis (PI). Clinical peri-implant parameters, such as probing pocket depth (PPD), % of plaque, and bleeding on probing (BOP), and the whole unstimulated saliva samples were evaluated at baseline and 3 months after treatment. The MU group received nonsurgical peri-implant treatment, while the PI group received open-flap procedures. The levels of sTREM-1, PGLYRP-1, MMP-8, and TIMP-1 were analyzed using enzyme-linked immunosorbent assays. BOP, plaque levels, and PPD significantly reduced after treatment in both groups. A significant decrease in the salivary levels of sTREM-1, MMP-8, and TIMP-1 in the PI group and PGLYRP1 and TIMP-1 in the MU group were observed. Salivary levels of sTREM-1 were significantly reduced in patients with PI but not with MU. Additionally, peri-implant treatment had a significantly higher impact on MMP-8 reduction in patients with PI than in those with MU.

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Section: Discussionsupporting

confidence: 89%

Peri-Implant Surgical Treatment Downregulates the Expression of sTREM-1 and MMP-8 in Patients with Peri-Implantitis: A Prospective Study

Neves

Elangovan

Teixeira

et al. 2022

IJERPH

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“…Given the likely bidirectional relationship between both diseases and the chronic inflammatory process, the key pathologic element in both, it is reasonable to hypothesize that rheumatoid arthritis treatment, based on host-modulating therapies, may have a significant impact on the periodontal status of rheumatoid arthritis patients with periodontitis [114][115][116][117][118][119][120][121][122][123][124][125][126][127][128][129] (Table 6). In one of the first studies on this premise, Pers et al 114 observed that antitumor necrosis factor-alpha treatment improved the periodontal status of rheumatoid arthritis patients with periodontitis.…”

Section: Effec T Of Rheumatoid Arthritis Tre Atment On Peri Odontitismentioning

confidence: 99%

Periodontitis and rheumatoid arthritis: What have we learned about their connection and their treatment?

González-Febles

Sanz

2021

Periodontology 2000

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Rheumatoid arthritis and periodontitis are chronic inflammatory diseases defined respectively by the destruction of the articular cartilage and tooth‐supporting periodontal tissues. Although the epidemiologic evidence for an association between these two diseases is still scarce, there is emerging scientific information linking specific bacterial periodontal pathogens, such as Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans, in the citrullination process, leading to autoantibody formation and compromised immunotolerance of the susceptible patient to rheumatoid arthritis. In this review, we update the existing information on the evidence, not only regarding the epidemiologic association, but also the biologic mechanisms linking these two diseases. Finally, we review information emerging from intervention studies evaluating whether periodontal treatment could influence the initiation and progression of rheumatoid arthritis.

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“…It is not yet well known whether treatment with biological DMARDS, besides its effect on the periodontal inflammatory burden, also results in changes in saliva and gingival crevicular fluid (GCF). For example, Äyräväinen et al, () recently showed that treatment of RA with synthetic or biologic DMARDs did not affect salivary MMP‐8 levels (Äyräväinen et al, ).…”

Section: Introductionmentioning

confidence: 99%

Cytokines in gingivocrevicular fluid of rheumatoid arthritis patients: A review of the literature

et al. 2019

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Objective Rheumatoid arthritis (RA) and periodontitis share several pathological features including bone and soft tissue destruction and high levels of circulating inflammatory proteins. Studies related to cytokines in the periodontal inflammatory exudate (gingivocrevicular fluid, GCF) of RA patients might provide insight into the association between periodontitis and RA. The aim of our study was to review the literature on cytokines in GCF of RA patients including the effect of anti‐rheumatic treatment with biological disease‐modifying anti‐rheumatic drugs (DMARDs) and periodontal treatment on these cytokines. Materials and methods MedLine/PubMed searches with different combinations of keywords “rheumatoid arthritis or RA” and “crevicular fluid or GCF” until June 2019 revealed 64 articles. Ten cross‐sectional observational studies and nine treatment studies fulfilled the inclusion criteria. Results Rheumatoid arthritis patients have increased circulating and GCF levels of pro‐inflammatory cytokines and proteins, despite anti‐rheumatic treatment with biological DMARDs. Presence of periodontitis was accompanied by higher cytokine and protein levels. Treatment of periodontitis resulted in a decrease of these levels. Conclusion Analysis of GCF of RA patients reveals that the relationship between periodontitis and RA is bidirectional, probably caused by a non‐specific inflammatory burden. Data for a specific relationship are barely present in GCF.

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Anti‐rheumatic medication and salivary MMP‐8, a biomarker for periodontal disease

Abstract: The use of synthetic or biologic DMARDs did not affect salivary MMP-8 levels in RA patients regardless the duration of RA.

Cited by 17 publications

References 37 publications

Peri-Implant Surgical Treatment Downregulates the Expression of sTREM-1 and MMP-8 in Patients with Peri-Implantitis: A Prospective Study

Peri-Implant Surgical Treatment Downregulates the Expression of sTREM-1 and MMP-8 in Patients with Peri-Implantitis: A Prospective Study

Periodontitis and rheumatoid arthritis: What have we learned about their connection and their treatment?

Cytokines in gingivocrevicular fluid of rheumatoid arthritis patients: A review of the literature

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