Periodontitis and rheumatoid arthritis: What have we learned about their connection and their treatment?

González-Febles, Jerián; Sanz, Mariano

doi:10.1111/prd.12385

Cited by 77 publications

(48 citation statements)

References 165 publications

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“…; Sc, Streptococcus constellatus. References: [A] : Cardoso et al ( 2018 ); [B] : Bui et al ( 2019 ), [C] : Fine et al ( 2020 ), [D] : Gallimidi et al ( 2015 ), [E] : Ha et al ( 2015 ), [F] : Lamster and Pagan ( 2017 ), [G] : Jepsen et al ( 2020 ), [H] : Minty et al ( 2019 ), [I] : Torrungruang et al ( 2018 ), [J] : Suh et al ( 2019 ), [K] : Schenkein et al ( 2020 ), [L] : Singhal et al ( 2016 ), [M] : Cecoro et al ( 2020 ), [N] : Baeza et al ( 2020 ), [O] : Furutama et al ( 2020 ), [P] : Ferguson et al ( 2020 ) [Q] : Preshaw et al ( 2020 ), [R] : Sukumar and Tadepalli ( 2021 ), [S] : Badran et al ( 2020 ), [T] : Coke et al ( 2021 ), [U] : Han and Wang ( 2013 ), [V] : González-Febles and Sanz ( 2021 ), [W] : Maldonado et al ( 2020 ), [X] : Bunte and Beikler ( 2019 ), [Y] : Poole et al ( 2013 ), [Z] : Poole et al ( 2015 ), [Aa] : Stein et al ( 2012 ), [Ab] : Bobetsis et al ( 2020 ) .…”

Section: Medical Aspects Of Periodontal Inflammationmentioning

confidence: 99%

Periodontal Inflammation and Systemic Diseases: An Overview

2021

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Periodontitis is a common inflammatory disease of infectious origins that often evolves into a chronic condition. Aside from its importance as a stomatologic ailment, chronic periodontitis has gained relevance since it has been shown that it can develop into a systemic condition characterized by unresolved hyper-inflammation, disruption of the innate and adaptive immune system, dysbiosis of the oral, gut and other location's microbiota and other system-wide alterations that may cause, coexist or aggravate other health issues associated to elevated morbi-mortality. The relationships between the infectious, immune, inflammatory, and systemic features of periodontitis and its many related diseases are far from being fully understood and are indeed still debated. However, to date, a large body of evidence on the different biological, clinical, and policy-enabling sources of information, is available. The aim of the present work is to summarize many of these sources of information and contextualize them under a systemic inflammation framework that may set the basis to an integral vision, useful for basic, clinical, and therapeutic goals.

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Section: Medical Aspects Of Periodontal Inflammationmentioning

confidence: 99%

Periodontal Inflammation and Systemic Diseases: An Overview

2021

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“…Porphyromonas gingivalis , a Gram-negative anaerobic bacterium, possessing a complex of virulence factors including gingipains, lipopolysaccharide (LPS), and capsular polysaccharides, is a primary periopathogen in the initiation and development of periodontitis. P. gingivalis is also deemed to be a risk factor for various diseases and conditions, including atherosclerosis [ 3 ], rheumatoid arthritis [ 4 ], non-alcoholic steatohepatitis [ 5 ], and Alzheimer’s disease [ 6 ]. P. gingivalis can also diffuse to distal sites or the circulation from local sites of infection [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Inflammatory response of gut, spleen, and liver in mice induced by orally administeredPorphyromonas gingivalis

Liu

Huang

et al. 2022

Journal of Oral Microbiology

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Background Periodontitis is a chronic multifactorial inflammatory disease. Porphyromonas gingivalis is a primary periopathogen in the initiation and development of periodontal disease. Evidence has shown that P. gingivalis is associated with systemic diseases, including IBD and fatty liver disease. Inflammatory response is a key feature of diseases related to this species. Methods C57BL/6 mice were administered either PBS, or P. gingivalis . After 9 weeks, the inflammatory response in gut, spleen, and liver was analyzed. Results The findings revealed significant disturbance of the intestinal microbiota and increased inflammatory factors in the gut of P. gingivalis -administered mice. Administrated P. gingivalis remarkably promoted the secretion of IRF-1 and activated the inflammatory pathway IFN-γ/STAT1 in the spleen. Histologically, mice treated with P. gingivalis exhibited hepatocyte damage and lipid deposition. The inflammatory factors IL-17a, IL-6, and ROR-γt were also upregulated in the liver of mice fed with P. gingivalis . Lee’s index, spleen index, and liver index were also increased. Conclusion These results suggest that administrated P. gingivalis evokes inflammation in gut, spleen, and liver, which might promote the progression of various systemic diseases.

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“…As a chronic autoimmune disease, Rheumatoid arthritis is developed due to genetics and environmental risks, and periodontitis is one of the consistently reported risk factors ( González-Febles and Sanz, 2021 ). Most importantly, P. gingivalis is one of the commonly found bacterium in periodontitis patients ( Jia et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

The Relationship Between Porphyromonas Gingivalis and Rheumatoid Arthritis: A Meta-Analysis

Guo

Oduro

et al. 2022

Front. Cell. Infect. Microbiol.

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Rheumatoid arthritis (RA) is a systematical autoimmune disease, characterized by chronic synovial joint inflammation and hurt. Porphyromonas gingivalis(P. gingivalis) can cause life-threatening inflammatory immune responses in humans when the host pathogenic clearance machinery is disordered. Some epidemiological studies have reported that P. gingivalis exposure would increase the prevalence of RA. However, the results remain inconsistent. Therefore, a meta-analysis was done to systematically analyze the relationship between P. gingivalis exposure and the prevalence of rheumatoid arthritis. Database including Cochrane Library, Web of Science, PubMed, and EMBASE were searched for published epidemiological articles assessed the relationship between P. gingivalis and RA. Obtained studies were screened based on the predefined inclusion and exclusion criteria. The overall Odds Ratios (ORs) of incorporated articles were pooled by random-effect model with STATA 15.1 software. The literature search returned a total of 2057 studies. After exclusion, 28 articles were included and analyzed. The pooled ORs showed a significant increase in the risk of RA in individuals with P. gingivalis exposure (OR = 1.86; 95% CI: 1.43-2.43). Subgroup analysis revealed that pooled ORs from populations located in Europe (OR = 2.17; 95% CI: 1.46-3.22) and North America (OR = 2.50; 95% CI: 1.23-5.08) were significantly higher than that from population in Asia (OR = 1.11; 95% CI: 1.03-1.20). Substantial heterogeneity was observed but did not significantly influence the overall outcome. In conclusion, our results indicated P. gingivalis exposure was a risk factor in RA. Prompt diagnosis and management decisions on P. gingivalis antimicrobial therapy would prevent rheumatoid arthritis development and progression.

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Periodontitis and rheumatoid arthritis: What have we learned about their connection and their treatment?

Cited by 77 publications

References 165 publications

Periodontal Inflammation and Systemic Diseases: An Overview

Periodontal Inflammation and Systemic Diseases: An Overview

Inflammatory response of gut, spleen, and liver in mice induced by orally administeredPorphyromonas gingivalis

The Relationship Between Porphyromonas Gingivalis and Rheumatoid Arthritis: A Meta-Analysis

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