Anti-rheumatic effect of quercetin and recent developments in nano formulation

Guan, Feng; Wang, Qi; Bao, Yongping; Chao, Yimin

doi:10.1039/d0ra08817j

Cited by 26 publications

(12 citation statements)

References 101 publications

(121 reference statements)

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“…Overall, there are several strategies that can be adopted to increase the solubility and subsequent bioavailability of flavonoids with therapeutic potential. Although much progress has been recently made, novel drug delivery systems suitable for an optimized topical application should continue to be explored [ 112 , 154 , 155 , 156 , 157 ]. A summary of the therapeutic application of flavonoids and the different nanocarriers used to enhance their delivery to the skin is described in Table 3 .…”

Section: Cutaneous Delivery Systems Of Flavonoids For Treatment Of Skin Pathologiesmentioning

confidence: 99%

On the Development of a Cutaneous Flavonoid Delivery System: Advances and Limitations

2021

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Flavonoids are one of the vital classes of natural polyphenolic compounds abundantly found in plants. Due to their wide range of therapeutic properties, which include antioxidant, anti-inflammatory, photoprotective, and depigmentation effects, flavonoids have been demonstrated to be promising agents in the treatment of several skin disorders. However, their lipophilic nature and poor water solubility invariably lead to limited oral bioavailability. In addition, they are rapidly degraded and metabolized in the human body, hindering their potential contribution to the prevention and treatment of many disorders. Thus, to overcome these challenges, several cutaneous delivery systems have been extensively studied. Topical drug delivery besides offering an alternative administration route also ensures a sustained release of the active compound at the desired site of action. Incorporation into lipid or polymer-based nanoparticles appears to be a highly effective approach for cutaneous delivery of flavonoids with good encapsulation potential and reduced toxicity. This review focuses on currently available formulations used to administer either topically or systemically different classes of flavonoids in the skin, highlighting their potential application as therapeutic and preventive agents.

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Section: Cutaneous Delivery Systems Of Flavonoids For Treatment Of Skin Pathologiesmentioning

confidence: 99%

On the Development of a Cutaneous Flavonoid Delivery System: Advances and Limitations

2021

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“…In certain diseases like rheumatoid arthritis, ulcer, etc., inflammation worsens the disease profile due to the release of inflammatory mediators. Research confirmed quercetin’s anti-inflammatory effect was due to inhibition of proinflammatory cytokines, ATP and nuclear factor kappa B (IkBa) binding sites [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

An insight into anticancer, antioxidant, antimicrobial, antidiabetic and anti-inflammatory effects of quercetin: a review

et al. 2022

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Flavonoids are present naturally in many fruits and vegetables including onions, apples, tea, cabbage, cauliflower, berries and nuts which provide us with quercetin, a powerful natural antioxidant and cytotoxic compound. Due to antioxidant property, many nutraceuticals and cosmeceuticals products contain quercetin as a major ingredient nowadays. Current review enlightened sources and quercetin’s role as an antioxidant, antimicrobial, antidiabetic, anticancerous and anti-inflammatory agent in medical field during last 5 to 6 years. Literature search was systematically done using scientific for the published articles of quercetin. A total of 345 articles were reviewed, and it was observed that more than 40% of articles were about quercetin’s use as an antioxidant agent, more than 25% of studies were about its use as an anticancer agent, and articles on antimicrobial activity were more than 15%. 10% of the articles showed anti-inflamamatory effects of quercetin. Literature search also revealed that quercetin alone and its complexes with chitosan, metal ions and polymers possessed good antidiabetic properties. Thus, the review focuses on new therapeutic interventions and drug delivery system of quercetin in medical field for the benefit of mankind.

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“… 35 Recently, the potential effects of important natural plant-based compounds and their derivatives such as resveratrol, curcumin, matrine, quercetin, and sylimarin, have been extensively investigated on a variety of disorders including autoimmunity. 16 , 36 – 43 The majority of natural/herbal medications can control different diseases by inhibiting pro-inflammatory mediators and increasing the frequency and activity of Tregs. 36 , 44 – 46 Therefore, medicinal plants are important sources for development of new immunomodulatory and anti-inflammatory drugs.…”

Section: Discussionmentioning

confidence: 99%

Dose-dependent effects of oleuropein administration on regulatory T-cells in patients with rheumatoid arthritis: An in vitro approach

Yousefi

Mirsanei

Bitaraf

et al. 2022

Int J Immunopathol Pharmacol

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Introduction: Rheumatoid arthritis (RA) is an autoimmune disease that is identified with chronic inflammation and progressive destruction of the joints. The defective activity of regulatory T cells (Tregs) plays a crucial role in RA development. Oleuropein (OLEU) is the most common polyphenolic compound in olive leaf extracts with numerous pharmacological activities. In this study, the potential effects of OLEU in shifting CD4+ T cells toward Tregs are evaluated in patients with RA. Methods 32 healthy controls (HC) and 45 RA patients were included in two groups. The immunoturbidometric technique was used to measure serum levels of c-reactive protein (CRP) and rheumatoid factor (RF). Isolated CD4+ T cells from peripheral blood mononuclear cells (PBMCs) of HC and RA patients were cultured with appropriate concentrations of OLEU. The cytotoxicity effects of OLEU were determined using the MTT assay at 24, 48, and 72 h. The percentage of CD4+CD25 + FoxP3 regulatory T lymphocytes (Tregs) and the expressions of IL-10 and TGF-β were evaluated by flow cytometry and immunoassay techniques after treatment of cells with different concentrations of OLEU for 24 h. The serum levels of RF and CRP in patients with RA were 11.8 ± 5.32 IU/ml and 6.36 ± 5.82 mg/l, respectively. Results OLEU had a dose-dependent effect on the CD4+ T cells via increasing the frequency of CD4+CD25 + FoxP3 Tregs ( p = 0.0001). Moreover, it induced the production of IL-10 ( p = 0.0001) and TGF-β ( p < 0.01) in both HC and RA patients. Conclusion The findings of this study suggest that OLEU may have immunomodulatory effects by inducing Tregs, and it might help in developing a novel nutrition strategy for management of autoimmune diseases such as RA.

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Anti-rheumatic effect of quercetin and recent developments in nano formulation

Abstract: Quercetin is a potential anti-rheumatoid drug. Nano formulation strategies could improve its solubility and efficacy.

Cited by 26 publications

References 101 publications

On the Development of a Cutaneous Flavonoid Delivery System: Advances and Limitations

On the Development of a Cutaneous Flavonoid Delivery System: Advances and Limitations

An insight into anticancer, antioxidant, antimicrobial, antidiabetic and anti-inflammatory effects of quercetin: a review

Dose-dependent effects of oleuropein administration on regulatory T-cells in patients with rheumatoid arthritis: An in vitro approach

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