Anti-recurrent Immunocorrection in Gynecology Andrology and Proctology

Бенюк, В. О.; Goncharenko, V.M.; Kurchenko, Andrii; Tatskyy, O.F.; Konovalenko, Sergii; Vintoniuk, Svitlana; Melnikov, S.M.; Нуріманов, К. Р.; Подпрятов, С. С.

doi:10.11648/j.iji.20200801.11

Cited by 3 publications

(6 citation statements)

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“…In this sense, it seems promising to use natural immune peptides, which enhance the immune surveillance over the endometrioma and prevent relapses. [37]…”

Section: Discussionmentioning

confidence: 99%

“…In this regard, the most interesting is the nonspecific mechanism of activation by immune proteins of immunocompetent cells. Due to the effect of tissue accumulation, immune peptides attach to cell membranes in the target organ and thus provoke their more productive interactions with T-lymphocytes, NK-cells and macrophages [33,34,37]. On the one hand, interacting with the ectopically located endometrial tissue, RJP-1 reduces perifocal inflammation, on the other hand, defensins stimulate the synthesis of TNF-α by macrophages.…”

Section: Figure 1 Immunolocalization Of Cd26 In the Eutopic (A-c) Anmentioning

confidence: 99%

“…The effect of tissue accumulation of exogenous immune peptides creates an active competitive environment in the microenvironment of ectopia and predictably disrupts the ability of ectopic cells to resist immune surveillance, that is, to synthesize the required amount of ICAM-1, IL-6, IL-8, as well as FasL to provoke apoptosis of T-lymphocytes. This restores immune homeostasis and restarts the productive work of the immune system against endometriotic foci ( Figure 2) [1,14,15,37]. Clinical experience confirms that the achievement of a significant effect of immunocorrection in endometriosis requires the use of Arecur suppositories 2 times a day for 20 days, the course can be repeated up to 4 times a year.…”

Section: Figure 1 Immunolocalization Of Cd26 In the Eutopic (A-c) Anmentioning

confidence: 99%

“…Clinical experience confirms that the achievement of a significant effect of immunocorrection in endometriosis requires the use of Arecur suppositories 2 times a day for 20 days, the course can be repeated up to 4 times a year. Arecur does not drain the immune system, is compatible with antibiotics, hormone therapy and chemotherapy drugs [37].…”

Section: Figure 1 Immunolocalization Of Cd26 In the Eutopic (A-c) Anmentioning

confidence: 99%

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Prospects for the Treatment of Endometriosis: The Effect of Immune Peptides on the Reactivation of Immune Surveillance over Ectopic Endometrial Cells

Захаренко¹,

Tatskiy²,

Konovalenko³

2020

JGO

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“…In this sense, it seems promising to use natural immune peptides, which enhance the immune surveillance over the endometrioma and prevent relapses. [37]…”

Section: Discussionmentioning

confidence: 99%

Section: Figure 1 Immunolocalization Of Cd26 In the Eutopic (A-c) Anmentioning

confidence: 99%

Section: Figure 1 Immunolocalization Of Cd26 In the Eutopic (A-c) Anmentioning

confidence: 99%

Section: Figure 1 Immunolocalization Of Cd26 In the Eutopic (A-c) Anmentioning

confidence: 99%

See 2 more Smart Citations

Prospects for the Treatment of Endometriosis: The Effect of Immune Peptides on the Reactivation of Immune Surveillance over Ectopic Endometrial Cells

Захаренко¹,

Tatskiy²,

Konovalenko³

2020

JGO

Self Cite

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“…[12,16,18,19]. Most importantly, contact of exogenous peptides with the mucosa stimulates the membranes of immunocompetent cells and increases the expression of secretory immunoglobulin A -the body's main weapon against pathogenic bacteria and viruses (Figure 2) [25].…”

Section: Figure 2 Increased Levels Of Siga (Pkg / Ml) Of the Mucosa A...mentioning

confidence: 99%

COPD: Perspectives of Immune Peptide Therapy and Lung Cancer Prevention

Panashchuk¹,

Tatskyi²,

Konovalenko³

2021

AJIM

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Background: Chronic obstructive pulmonary disease (COPD) occurs due to chronic inflammation, which leads to thickening of the airway walls, increased mucus production and, ultimately, permanent changes in lung structure. Meta-analysis indicates an increased risk of lung cancer in patients with COPD, so timely and comprehensive cancer prevention is extremely important. Objective: Determine the mechanisms of interaction between immune peptides and immunocompetent cells, which lead to the elimination of pathogens and prevent the development of metaplasia on the background of chronic inflammation. Methods: Selection and analysis of open access scientific publications. Results: Restoring the ability of secretory cells to synthesize IgA and maintaining this synthesis at the appropriate level can provide the necessary protection of the respiratory system from infection. Strengthening immune surveillance over the mucous membrane promotes not only the elimination of pathogens, but also to the destruction and removal of disabled and infected cells and cells that have undergone metaplasia -this is how the immunity program is implemented to counteract infection and prevent cancer. Conclusion: The use of exogenous anti-infective peptides for the treatment and prevention of exacerbations of COPD in the context of antibiotic resistance, to stimulate airway immune function and to prevent cancer is currently considered a promising area in clinical pulmonology.

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Expression of SARS-CoV-2 Host Cell Entry Factors in Immune System Components of Healthy Individuals and Its Relevance for COVID-19 Immunopathology

Kumar

Narayan

et al. 2021

Viral Immunology

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Intense immunological dysregulation including immune cell lesions has been characteristically observed in severe cases of coronavirus disease-2019 (COVID-19), for which molecular mechanisms are not properly understood. A study of physiological expressions of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) host cell entry-related factors in immune system components may help explain molecular mechanisms involved in COVID-19 immunopathology. We analyzed transcriptomic and proteomic expression metadata for SARS-CoV-2 host cell entry receptor ACE2 and entry associated proteases (TMPRSS2, CTSL, and FURIN) in silico across immune system components including the blood lineage cells. ACE2 was not detected in any of the studied immune cell components; however, varying transcriptomic and proteomic expressions were observed for TMPRSS2, CTSL, and FURIN. Nondetectable expressions of SARS-CoV-2 host cell entry receptor ACE2 in immune system components or blood lineage cells indicate it does not mediate immune cell lesions in COVID-19. Alternative mechanisms need to be explored for COVID-19 immunopathogenesis.

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Anti-recurrent Immunocorrection in Gynecology Andrology and Proctology

Cited by 3 publications

References 0 publications

Prospects for the Treatment of Endometriosis: The Effect of Immune Peptides on the Reactivation of Immune Surveillance over Ectopic Endometrial Cells

Prospects for the Treatment of Endometriosis: The Effect of Immune Peptides on the Reactivation of Immune Surveillance over Ectopic Endometrial Cells

COPD: Perspectives of Immune Peptide Therapy and Lung Cancer Prevention

Expression of SARS-CoV-2 Host Cell Entry Factors in Immune System Components of Healthy Individuals and Its Relevance for COVID-19 Immunopathology

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