Anti-Quorum Sensing Agents from Natural Sources

Bouyahya, Abdelhakim; Omari, Nasreddine El; Menyiy, Naoual El; Guaouguaou, Fatima-Ezzahrae; Balahbib, Abdelaali; Chamkhi, Imane

doi:10.1007/978-981-16-3120-7_17

Cited by 4 publications

(3 citation statements)

References 62 publications

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“…In our model, we introduced a QQ which acts like an enzyme degrading the QS signal. Even for the AHL-type QS signals, there are many different sources of enzymatic degradation known, not only bacteria but also eukaryotes [4,32]. Models of other, maybe more specific quorum quenching systems, might require different formulations.…”

Section: Discussionmentioning

confidence: 99%

A mathematical model of quorum quenching in biofilm colonies and its potential role as an adjuvant for antibiotic treatment

et al. 2022

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We extend a previously presented mesoscopic (i.e. colony scale) mathematical model of the reaction of bacterial biofilms to antibiotics. In that earlier model, exposure to antibiotics evokes two responses: inactivation as the antibiotics kill the bacteria, and inducing a quorum sensing based stress response mechanism upon exposure to small sublethal dosages. To this model we add now quorum quenching as an adjuvant to antibiotic therapy. Quorum quenchers are modeled like enzymes that degrade the quorum sensing signal concentration. The resulting model is a quasilinear system of seven reaction-diffusion equations for the dependent variables volume fractions of upregulated (protected), downregulated (unprotected) and inert (inactive) biomass [particulate substances], and for concentrations of a growth promoting nutrient, antibiotics, quorum sensing signal, and quorum quenchers [dissolved substances]. The biomass fractions are subject to two nonlinear diffusion effects: (i) degeneracy, as in the porous medium equation, where biomass vanishes, and (ii) a super-diffusion singularity where as it attains its theoretically possible maximum. We study this model in numerical simulations. Our simulations suggest that for maximum efficacy quorum quenchers should be applied early on before quorum sensing induction in the biofilm can take place, and that an antibiotic strategy that by itself might not be successful can be notably improved upon if paired with quorum quenchers as an adjuvant.

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Section: Discussionmentioning

confidence: 99%

A mathematical model of quorum quenching in biofilm colonies and its potential role as an adjuvant for antibiotic treatment

et al. 2022

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“…Flavonoids are one of a large class of plant medicinal components with antioxidant, anti-inflammatory, antiallergic, anticancer, antiviral, and antifungal properties ( 15 ). Recent studies have shown that, in addition to antibacterial effects, some flavonoids also inhibit bacterial biofilm formation by affecting bacterial adhesion, motility, and quorum sensing (QS) ( 16 ). Chenopodium ambrosioides L., an annual or perennial herb, is widely distributed on the planet, and its derived essential oil is commonly used in folk medicine as an antirheumatic, anti-inflammatory, antipyretic, anthelmintic, antifungal, and antiulcer agent ( 17 – 21 ).…”

Section: Introductionmentioning

confidence: 99%

Global Downregulation of Penicillin Resistance and Biofilm Formation by MRSA Is Associated with the Interaction between Kaempferol Rhamnosides and Quercetin

Zhang

Cao

et al. 2022

Microbiol Spectr

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In this study, the synergistic antibacterial and antibiofilm effects of the traditional herb C. ambrosioides L. and the classic antibiotic penicillin G on MRSA provide a potential strategy to deal with the rapid development of MRSA antibiotic resistance. This study also provides a theoretical basis for further optimizing the combined effect of kaempferol rhamnosides, quercetin, and penicillin G and exploring anti-MRSA biofilm infection research with SarA and σB as drug targets.

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“…Today, there is an urgent need to discover ways to solve the problem of antibiotic resistance, and natural resources have gained importance at this point. In research in this field, the evaluation of antibacterial and antiquorum-sensing activities of medicinal herbs is becoming more popular day by day [2].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Potential Antibacterial Activity of Berberis Crataegina Dc.: With Focus on Quorum Sensing Inhibition of Chromobacterium Violaceum Atcc 12472

Dereli

Arin

Önem

2022

Ankara Ecz. Fak. Derg.

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Objective: In the present study described here, we set out to look into the quorum sensing inhibitory activity of the methanolic seed extract of Berberis crataegina DC. through quorum sensing -controlled inhibition of violacein pigment production in Chromobacterium violaceum ATCC 12472. In addition, the antibacterial activity of the extract on various Gram-negative and Gram-positive standard strains was evaluated. Also phenolic contents in the extract were detected by using HPLC analysis. Material and Method: “The phytochemical profile of the seed extract was performed by High-Performance Liquid Chromatography technique. Antibacterial activity assays were performed on the extract using the agar well method and inhibition of the violacein pigment production was investigated spectrophotometrically. Result and Discussion: According to antibacterial activity results Gram negative bacteria were more resistant than Gram positive bacteria and violacein pigment production was inhibited by 66% percentage. Phytochemical analysis results also showed that the major component in the extract is chlorogenic acid, with a value of 1974.91 µg/mL.

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Anti-Quorum Sensing Agents from Natural Sources

Cited by 4 publications

References 62 publications

A mathematical model of quorum quenching in biofilm colonies and its potential role as an adjuvant for antibiotic treatment

A mathematical model of quorum quenching in biofilm colonies and its potential role as an adjuvant for antibiotic treatment

Global Downregulation of Penicillin Resistance and Biofilm Formation by MRSA Is Associated with the Interaction between Kaempferol Rhamnosides and Quercetin

Evaluation of the Potential Antibacterial Activity of Berberis Crataegina Dc.: With Focus on Quorum Sensing Inhibition of Chromobacterium Violaceum Atcc 12472

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