Anti-proliferative cassane-type diterpenoids from the seeds of <i>Caesalpinia minax</i>

Xu, Yunshao; Shi, Wei; Lu, Feng; Cao, Jun; Zhang, Qingwen; Lu, Jin‐Jian; Yang, Yuxiang; Lin, Ligen

doi:10.1080/14786419.2020.1853729

Cited by 7 publications

(1 citation statement)

References 24 publications

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“…Previous phytochemical investigations have reported many cassane‐type diterpenoids, [3,4] sterols [5] and flavonoids [6,7] from different parts of C. bonduc . As the main chemical constituents, cassane‐type diterpenoids show a variety of pharmacological activities, such as antiviral, [8] antiproliferative, [9,10] antioxidant, [11] antimalarial, [12] antibacterial, [11] antihelmintic, [13] antineoplastic, [14] anti‐inflammatory, [15] cytotoxic [16] and pro‐apoptotic [16] activities. In our searching for bioactive constituents of traditional Chinese medicines, ten cassane‐type diterpenoids ( 1 – 10 ) were isolated from the seeds of C .…”

Section: Introductionmentioning

confidence: 99%

Cassane‐Type Diterpenoids from the Seeds of Caesalpinia bonduc (L.) Roxb.

Cao

Lou

et al. 2021

Chemistry & Biodiversity

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Ten new cassane‐type diterpenoids were isolated from the seeds of Caesalpinia bonduc (L.) Roxb., including 6α‐hydroxycaesalpinin P (1), 14‐epi‐caesalpinin E1 (2), 6‐deacetylcaesalmin Z (3), 14‐epi‐caesalmin Z (4), caesalpinolides I (5), K (6), L (7), M (9) and N (10), and 14‐epi‐neocaesalpin L (8). Their planar structures and absolute configurations were fully determined by comprehensive spectroscopic methods, including 2D NMR and electronic circular dichroism spectra. Compounds 1–4 are tetracyclic cassane diterpenoids possessing a furan ring, and compounds 5–10 are tetracyclic cassane diterpenoids possessing a fused butenolide moiety. The anti‐inflammatory and cytotoxic activities of the isolates were evaluated, while none of them showed obvious effects. The current study identified ten new cassane‐type diterpenoids from the seeds of C. bonduc (L.) Roxb., which enriched the chemical diversity of the titled herbal medicine.

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