Chemical composition, biological activities and traditional uses of plants from the segregated genus Caesalpinia sensu lato

Nascimento, Bruna Oliveira do; David, Jorge M.

doi:10.1007/s11101-023-09874-z

Cited by 3 publications

(1 citation statement)

References 174 publications

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“…Historically, this plant has been utilized as a carminative and to heal dizziness and fainting, indicating its potential safety and capacity as a medicinal agent. C. mimosoides Lamk exhibits promising biological activities, including anticancer, antibacterial, antioxidant, anti-inflammatory, and neuroprotective effects [23][24][25][26][27][28][29]. While the virucidal effects of this plant species have not yet been investigated, previous studies revealed that C. minax and C. latisiliqua, which belong to the same genus, were rich in flavonoids, stilbene, phenolics, and other bioactive constituents and demonstrated promising antiviral activity [30,31].…”

Section: Introductionmentioning

confidence: 99%

Unveiling the Potent Antiviral and Antioxidant Activities of an Aqueous Extract from Caesalpinia mimosoides Lamk: Cheminformatics and Molecular Docking Approaches

Klamrak,

Nabnueangsap,

Narkpuk

et al. 2023

Foods

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Our group previously demonstrated that Caesalpinia mimosoides Lamk exhibits many profound biological properties, including anticancer, antibacterial, and antioxidant activities. However, its antiviral activity has not yet been investigated. Here, the aqueous extract of C. mimosoides was prepared from the aerial parts (leaves, stalks, and trunks) to see whether it exerts anti-influenza (H1N1) effects and to reduce the organic solvents consumed during extraction, making it a desirable approach for the large-scale production for medical uses. Our plant extract was quantified to contain 7 g of gallic acid (GA) per 100 g of a dry sample, as determined using HPLC analysis. It also exerts potent antioxidant activities comparable to those of authentic GA. According to untargeted metabolomics (UPLC-ESI(-)-QTOF-MS/MS) with the aid of cheminformatics tools (MetFrag (version 2.1), SIRIUS (version 5.8.3), CSI:FingerID (version 4.8), and CANOPUS), the major metabolite was best annotated as “gallic acid”, phenolics (e.g., quinic acid, shikimic acid, and protocatechuic acid), sugar derivatives, and dicarboxylic acids were deduced from this plant species for the first time. The aqueous plant extract efficiently inhibited an influenza A (H1N1) virus infection of MDCK cells with an IC50 of 5.14 µg/mL. Of equal importance, hemolytic activity was absent for this plant extract, signifying its applicability as a safe antiviral agent. Molecular docking suggested that GA interacts with conserved residues (e.g., Arg152 and Asp151) located in the catalytic inner shell of the viral neuraminidase (NA), sharing the same pocket as those of anti-neuraminidase drugs, such as laninamivir and oseltamivir. Additionally, other metabolites were also found to potentially interact with the active site and the hydrophobic 430-cavity of the viral surface protein, suggesting a possibly synergistic effect of various phytochemicals. Therefore, the C. mimosoides aqueous extract may be a good candidate for coping with increasing influenza virus resistance to existing antivirals.

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