Anti-proliferative and pro-apoptotic activities of two marine sponge-derived fungi extracts in HepG2, HCT116 and A375 cancer cell lines

Prata‐Sena, Maria; Ramos, Altina; Castro‐Carvalho, Bruno; Dethoup, Tida; Buttachon, Suradet; Kijjoa, Anake; Rocha, E

doi:10.1055/s-0034-1394594

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Cytotoxicity Of P Cyaneum Against Hepg2 Cell Lines1

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2017

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“…ESNA-A009 against LNcaP (prostate cancer), SK-BR3 (breast cancer), HT29 (colon cancer), and HELA (cervix cancer) (Cruz et al, 2006), Acremonium sp. against HCT-116 cells (Boot et al, 2007), Eurotium cristatum against MCF-7 (breast adenocarcinoma), NCI-H460 (lung cancer), and A375-C5 (melanoma) (Almeida et al, 2010), Xylaria psidii against bladder carcinoma cell line 5637 (ATCC HTB-9) (Tarman et al, 2011), Neosartorya siamensis against HepG2, HCT116 and A375 cancer cell lines (Prata-Sena et al, 2014) and Penicillium oxalicum against BGC823 gastric cancer and MOLT4 acute lymphoblastic leukemia cell lines (Bao et al, 2014) have been reported.…”

Section: Cytotoxicity Of P Cyaneum Against Hepg2 Cell Linesmentioning

confidence: 99%

In vitro Anticancer Activity of Marine Fungus Penicillium cyaneum

Salique¹,

Umamagheswari²

2017

Int.J.Curr.Res.Aca.Rev.

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Article InfoCancer is one of the most life-threatening diseases worldwide. Over the last few years, several metabolites produced by marine fungi have displayed potent anticancer effects. In the present study the anticancer activity of marine fungus Penicillium cyaneum against HepG 2 cells (human liver carcinoma cells) was assessed by in vitro cytotoxicity assay. The results revealed that P. cyaneum ethyl acetate extract showed potent cytotoxic effects in HepG 2 cells, with cell viability (29.5%) observed at 1000µg/mL. The IC 50 of ethyl acetate extract of P. cyaneum was 242.24 μg/mL.

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