Anti-plasmodial activities and X-ray crystal structures of rotenoids from Millettia usaramensis subspecies usaramensis

New Rotenoids and Coumaronochromonoids from the Aerial Part of <i>Boerhaavia erecta</i>

“…However, a literature search showed that the geometry of the B/C-ring junction of 12a-hydroxyrotenoids could be assigned by analysis of their chemical shift value of H-1 in their 1 H-NMR spectra as well as the comparison of their optical rotation value with those of known compounds. Literature revealed that the chemical shift value of H-1 would be δ H 6.6-7.0 for a cis-junction as in 4′,5′-dihydro-11,5′-dihydroxy-4′-methoxytephrosin, 20) or in (6aα,12aα)-12a-hydroxyelliptone, 21) and around δ H 8.0 for a trans-junction as in boeravinone C. 13) Further it has been observed that natural trans-junction 12a-hydroxyrotenoids would be either 6aα,12aβ-configuration as in coccineone E 19) and abronione 22) or 6aβ,12aα-configuration as in (+)-12a-epimilletosin 23) and usararotenoid C. 24) Those with a 6aα,12aβ-configuration display negative specific rotation, 13,19,22) while those with a 6aβ,12aα-configuration display positive specific rotation. 23,24) The chemical shift value for H-1 (δ H 8.33) of 3 is strongly deshielded when compared to the value observed for rotenoids with cis-B/C ring junction indicating that the B/C ring junction in 3 has a trans-geometry.…”

Barbigerone Inhibits Tumor Angiogenesis, Growth and Metastasis in Melanoma

“…This compound has exhibited profound pharmacological properties, such as antioxidant, 15-lipoxygenase inhibitory activity (Wangensteen et al, 2006), and anti-plasmodial activity (Yenesew et al, 2003). Our previous study has shown that BA exhibited antitumor activity on murine and human cancer cells by inducing apoptosis , and inhibits tumor angiogenesis and human non-small-cell lung cancer xenografts growth through VEGFR2 signaling pathways (Li et al, 2012).…”

Synthesis and biological evaluation of pyranoisoflavone derivatives as anti-inflammatory agents

“…1), a naturally occurring pyranoisoflavone, was first isolated from the seeds of Tephrosia barbigeria and can be obtained from other plants [14][15][16][17]. Previous studies discovered that barbigerone exhibited various pharmacological properties, such as anti-plasmodia, antioxidant and 15-lipoxygenase inhibitory activity [18,19]. Recently, barbigerone was also found to inhibit the proliferation of several cancer cell lines [16,20,21].…”