Anti-Photoaging Effect of Rhodiola rosea Fermented by Lactobacillus plantarum on UVA-Damaged Fibroblasts

Abstract

UVA can cause oxidative stress and photoaging of cells. We established a UVA-induced oxidative stress model of human fibroblasts and focused on the antioxidant and anti-photoaging ability of Lactobacillus plantarum fermented Rhodiola rosea. Compared with the unfermented Rhodiola rosea, Lactobacillus plantarum fermented Rhodiola rosea has better DPPH free radical and hydroxyl free radical scavenging ability, significantly reduces the content of reactive oxygen species (ROS), and improves the antioxidant level. Further studies have shown that the Lactobacillus plantarum fermented Rhodiola rosea can activate the Nrf2/Keap1 signaling pathway and up-regulate heme oxygenase-1 (HO-1), NAD(P)H quinone dehydrogenase 1 (NQO1), catalase (CAT) and glutathione Peptide peroxidase (GSH-Px), and protect fibroblasts from oxidative stress caused by UVA. On the other hand, Lactobacillus plantarum fermented Rhodiola rosea significantly reduces the activity of metalloproteinases in the cell, thereby increasing the collagen and elastin in the cell, alleviating the photoaging caused by UVA. Finally, we concluded that the antioxidant capacity and anti-photoaging ability of Lactobacillus plantarum fermented Rhodiola rosea are better than that of unfermented Rhodiola rosea.

Biotransformation of Cacumen platycladi Extract by Lactiplantibacillus plantarum CCFM1348 Promotes Hair Growth in Mice

“…CP promotes hair growth through the Akt/GSK3β/β-catenin signaling pathway . The efficacy of active ingredients in herbs can be increased by in vitro fermentation or in vivo intake of lactic acid bacteria with relevant enzymatic activities. , Here, we observed that compared with nonfermented CP, CP fermented by L. plantarum CCFM1348 significantly stimulated the proliferation of HDPCs (Figure ), increased the expression of β -catenin , VEGF, and IGF-1 , and downregulated TGF-β1, TGF -β2, and DKK-1 (Figures and ).…”

“…13 The efficacy of active ingredients in herbs can be increased by in vitro fermentation or in vivo intake of lactic acid bacteria with relevant enzymatic activities. 23,24 Here, we observed that compared with nonfermented CP, CP fermented by L. plantarum CCFM1348 significantly stimulated the proliferation of HDPCs (Figure 1), increased the expression of βcatenin, VEGF, and IGF-1, and downregulated TGF-β1, TGF-β2, and DKK-1 (Figures 2 and 3). Therefore, we selected L. plantarumCCFM1348 as the most suitable strain for CP fermentation and verified this using a mice model of alopecia.…”

Enhancement of Human Epidermal Cell Defense against UVB Damage by Fermentation of Passiflora edulis Sims Peel with Saccharomyces cerevisiae

“…According to [ 18 ], the DPPH and hydroxyl radical scavenging rates of PF and PW were determined. The determination of total antioxidant capacity was determined with the ABTS and FRAP method total antioxidant capacity test kit, and the experimental procedure was carried out according to the reagent manufacturer’s instructions.…”

Light exposure and its applications in human health

“…Therefore, studying the impact of light on skin cells is crucial for the development of skin health care and the treatment of skin diseases. Fibroblasts are the most common connective tissue cells in the body and are frequently used in light studies [78,79]. Studies have revealed that light has a notable effect on the proliferation and differentiation of fibroblasts and can regulate the extracellular matrix produced by them.…”