Anti-phospholipid antibodies in serum from patients with Guillain-Barré syndrome

Nakos, George; Tziakou, E.; Maneta-Peyret, Lilly; Nassis, Christos; Lekka, Marilena E.

doi:10.1007/s00134-005-2736-8

Cited by 19 publications

(9 citation statements)

References 33 publications

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“…Association of autoimmune diseases such as systematic lupus erythematosus, scleroderma with GBS (96) led researchers (Nakos et al) to ascertain the role of few antiphospholipid antibodies which include phosphatidic acid (PA), cardiolipin, phosphatidylethanolamine (PE), phosphatidylcholine (PC), phosphatidylserine (PS), phosphatidylinositol (PI), phosphatidylglyecerol (PG), and cardiolipin. The antibody levels were shown to decrease following 1-day treatment with γ-globulin (IVIG) and increased 2 days following cessation of treatment (82). This indicates that serum levels of anti-PI and anti-cardiolipin antibodies may be useful to monitor the response of the patient toward treatment with IVIG in GBS patients (82).…”

Section: Myelin Sheath-associated Markersmentioning

confidence: 99%

“…The antibody levels were shown to decrease following 1-day treatment with γ-globulin (IVIG) and increased 2 days following cessation of treatment (82). This indicates that serum levels of anti-PI and anti-cardiolipin antibodies may be useful to monitor the response of the patient toward treatment with IVIG in GBS patients (82).…”

Section: Myelin Sheath-associated Markersmentioning

confidence: 99%

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Peripheral Demyelinating Diseases: From Biology to Translational Medicine

et al. 2019

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Demyelinating diseases represent a spectrum of disorders that impose significant burden on global economy and society. Generally, the prognosis of these diseases is poor and there is no available cure. In recent decades, research has shed some light on the biology and physiology of Schwann cells and its neuroprotective effects in the peripheral nervous system (PNS). Insults to the PNS by various infectious agents, genetic predisposition and immune-related mechanisms jeopardize Schwann cell functions and cause demyelination. To date, there are no effective and reliable biomarkers for PNS-related diseases. Here, we aim to review the following: pathogenesis of various types of peripheral demyelinating diseases such as Guillain-Barre syndrome, Chronic Inflammatory Demyelinating Polyradiculoneuropathy, Anti-Myelin Associated Glycoprotein Neuropathy, POEMS syndrome, and Charcot-Marie-Tooth disease; emerging novel biomarkers for peripheral demyelinating diseases, and Schwann cell associated markers for demyelination.

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Section: Myelin Sheath-associated Markersmentioning

confidence: 99%

Section: Myelin Sheath-associated Markersmentioning

confidence: 99%

Peripheral Demyelinating Diseases: From Biology to Translational Medicine

et al. 2019

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“…α 6 β 4 immunoreactivity was detected in 66% of GBS patients [ 117 ]. Anti-phospholipid antibodies were detected in GBS patients and were downregulated by IVIg [ 118 ]. Patients with Gal-C-GBS were more frequently involved with sensory deficits, autonomic dysfunctions, and antecedent Mycoplasma pneumonia infections [ 119 ].…”

Section: Biomarkers Of Gbs ( Table 1 )mentioning

confidence: 99%

Biomarkers of Guillain‐Barré Syndrome: Some Recent Progress, More Still to Be Explored

Wang

Sun

Zhu

et al. 2015

Mediators of Inflammation

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Guillain-Barré syndrome (GBS), the axonal subtype of which is mainly triggered by C. jejuni with ganglioside-mimicking lipooligosaccharides (LOS), is an immune-mediated disorder in the peripheral nervous system (PNS) accompanied by the disruption of the blood-nerve barrier (BNB) and the blood-cerebrospinal fluid barrier (B-CSF-B). Biomarkers of GBS have been extensively explored and some of them are proved to assist in the clinical diagnosis and in monitoring disease progression as well as in assessing the efficacy of immunotherapy. Herein, we systemically review the literature on biomarkers of GBS, including infection-/immune-/BNB, B-CSF-B, and PNS damage-associated biomarkers, aiming at providing an overview of GBS biomarkers and guiding further investigations. Furthermore, we point out further directions for studies on GBS biomarkers.

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“…A SGB, uma polineuropatia inflamatória aguda mediada imunologicamente, é a desordem do SNP mais freqüentemente relacionada à SAF. Num estudo prospectivo, controlado e não randomizado, os aFL das classes IgA, IgM e IgG foram encontrados no grupo de pacientes com SGB, mas em nenhum dos nove pacientes do grupo controle (24) . O estudo ENMG dos pacientes revelou polineuropatia desmielinizante aguda.…”

Section: Manifestações Neurológicas Periféricas Na Safunclassified