Anti‐oxidative effect of the <i>β</i>‐blocker carvedilol on diabetic nephropathy in non‐obese type 2 diabetic rats

Yonekura, Yuriko; Fujii, Hideki; Nakai, Kentaro; Kono, Keiji; Goto, Shunsuke; Shinohara, Masami; Nishi, Shinichi

doi:10.1111/1440-1681.12447

Cited by 4 publications

(1 citation statement)

References 42 publications

(94 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…57 Declining Peroxisome Proliferator-Activated Receptor-g Levels Peroxisome proliferator-activated receptor-g (PPARg) is a nuclear receptor with activity Aged rats have reduced renal antioxidant capacity and enhanced renal injury. 78 Reduced oxidative stress lessens renal injury 197 Higher levels of oxidative stress in human aging and CKD. 73…”

Section: Increasing Wnt Activationmentioning

confidence: 99%

Renal Aging: Causes and Consequences

O’Sullivan

Hughes

Ferenbach

2016

JASN

369

307

View full text Add to dashboard Cite

Individuals age >65 years old are the fastest expanding population demographic throughout the developed world. Consequently, more aged patients than before are receiving diagnoses of impaired renal function and nephrosclerosis-age-associated histologic changes in the kidneys. Recent studies have shown that the aged kidney undergoes a range of structural changes and has altered transcriptomic, hemodynamic, and physiologic behavior at rest and in response to renal insults. These changes impair the ability of the kidney to withstand and recover from injury, contributing to the high susceptibility of the aged population to AKI and their increased propensity to develop subsequent progressive CKD. In this review, we examine these features of the aged kidney and explore the various validated and putative pathways contributing to the changes observed with aging in both experimental animal models and humans. We also discuss the potential for additional study to increase understanding of the aged kidney and lead to novel therapeutic strategies.

show abstract

Section: Increasing Wnt Activationmentioning

confidence: 99%

Renal Aging: Causes and Consequences

O’Sullivan

Hughes

Ferenbach

2016

JASN

369

307

View full text Add to dashboard Cite

show abstract

Renal protective effects of astragalus root in rat models of chronic kidney disease

et al. 2023

Self Cite

View full text Add to dashboard Cite

Background Astragalus root is a commonly used herb in traditional Chinese medicine. Although renoprotective effects have been reported in some clinical and experimental studies, the details remain unknown. Methods We used 5/6 nephrectomized rats as chronic kidney disease (CKD) models. At 10 weeks, they were divided into four groups, namely, CKD, low-dose astragalus (AR400), high-dose astragalus (AR800), and sham groups. At 14 weeks, they were sacrificed for the evaluation of blood, urine, mRNA expression in the kidney, and renal histopathology. Results Kidney dysfunction was significantly improved following astragalus administration (creatinine clearance: sham group; 3.8 ± 0.3 mL/min, CKD group; 1.5 ± 0.1 mL/min, AR400 group; 2.5 ± 0.3 mL/min, AR800 group; 2.7 ± 0.1 mL/min). Blood pressure, urinary albumin, and urinary NGAL levels were significantly lower in the astragalus-treated groups than those in the CKD group. Excretion of urinary 8-OHdG, an oxidative stress marker, and intrarenal oxidative stress were lower in the astragalus-treated groups than those in the CKD group. Furthermore, the mRNA expression of NADPH p22 phox, NADPH p47 phox, Nox4, renin, angiotensin II type 1 receptor, and angiotensinogen in the kidney was lower in the astragalus-treated groups compared with the CKD group. Conclusion This study suggests that astragalus root slowed CKD progression, possibly through the suppression of oxidative stress and the renin–angiotensin system.

show abstract