Renal Aging: Causes and Consequences

O'Sullivan, Eoin D; Hughes, Jeremy; Ferenbach, David A

doi:10.1681/asn.2015121308

Cited by 261 publications

(253 citation statements)

References 201 publications

(174 reference statements)

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“…It is well known that kidney function gradually decreases with age [1,2] but may be affected as well by various insults, polypharmacy being one of the most relevant [3,4].…”

Section: Introductionmentioning

confidence: 99%

Acute Kidney Injury and Chronic Kidney Disease in the Elderly and Polypharmacy

Formica¹,

Politano

Marazzi³

et al. 2018

Blood Purif

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Background: Acute kidney injury (AKI) incidence is reported to be 10 times higher in aged people. Related to their higher prevalence of chronic kidney disease (CKD), older patients are at high risk of toxic effects driven by drugs. Methods: The demographics, hospitalizations, visits to the Emergency Department, pharmacological therapy, and lab tests were analyzed in 71,588 individuals. Results: Data showed a higher prevalence of AKI as well as CKD in the elderly as compared to the younger group, with an associated very high mortality. A broad number of drugs was prescribed, ranging from 1 to 35, the majority being between 5 and 9 drugs. Conclusion: Elderly patients who developed AKI had a higher number of hospitalizations (underlying frailty), were more likely to progress to more severe stages of CKD and to be affected by other non-renal pathologies (associated comorbidities) and to be given heavier pharmacological prescriptions (polypharmacy).

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“…It is well known that kidney function gradually decreases with age [1,2] but may be affected as well by various insults, polypharmacy being one of the most relevant [3,4].…”

Section: Introductionmentioning

confidence: 99%

Acute Kidney Injury and Chronic Kidney Disease in the Elderly and Polypharmacy

Formica¹,

Politano

Marazzi³

et al. 2018

Blood Purif

View full text Add to dashboard Buy / Rent full text

show abstract

“…[1][2][3][4][5] Similarly, ageing affects glucose metabolism gravely that may end up in diabetogenic results. [1][2][3][4][5] Similarly, ageing affects glucose metabolism gravely that may end up in diabetogenic results.…”

Section: Discussionmentioning

confidence: 99%

Matrix metalloproteinase-9, 10, and stress hyperglycaemia in acute kidney injury

Guvercin¹,

Karakuş

Aksit³

et al. 2018

Eur J Clin Invest

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“…Younger age is consistently found to be associated with renal recovery, whether the recovery definition is simply being alive and not requiring RRT or non‐progression to CKD . In fact, younger patients have less baseline chronic structural lesions and a more favourable transcriptomic, haemodynamic and physiologic profile (namely less senescent cells) that empower them with a higher regenerative potential . The absence of baseline CKD is also strongly associated with a higher probability of renal recovery .…”

Section: Clinical Factors Associated With Renal Recoverymentioning

confidence: 99%

Renal regeneration after acute kidney injury

Coelho

Cabral

Lopes³

et al. 2018

Nephrology

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Acute kidney injury is common and associated with negative renal and patient outcomes. The human kidney has a real but limited regeneration capacity. Understanding renal regeneration may allow us to manipulate this process and thus develop therapeutic weapons to improve patients' outcome. In the first part of this paper we discuss the clinical factors associated with renal recovery: baseline patient particularities, acute kidney injury characteristics and the medical approach taken in the short and long-term. In the second part, the cellular and molecular mechanisms underlying renal regeneration are explored. The immune system seems to have an important role, first promoting inflammation and then tissue healing. Other players, such as cellular senescence, mitochondrial dysfunction, renal haemodynamics and metabolic reprogramming also have a role in renal regeneration. We aim to develop a short review of renal regeneration, offering a holistic view of this process.

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Renal Aging: Causes and Consequences

Cited by 261 publications

References 201 publications

Acute Kidney Injury and Chronic Kidney Disease in the Elderly and Polypharmacy

Acute Kidney Injury and Chronic Kidney Disease in the Elderly and Polypharmacy

Matrix metalloproteinase-9, 10, and stress hyperglycaemia in acute kidney injury

Renal regeneration after acute kidney injury

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