Anti-oxidative Effect of Fluvastatin in Hyperlipidemic Type 2 Diabetic Patients

Abstract

Abstract. An open-label prospective cross-over trial was performed to evaluate the antioxidative effect of fluvastatin in Japanese type 2 diabetics with hyperlipidemia. The study subjects were 10 patients who were on pravastatin (10 mg/day) or simvastatin (5 mg/day). After at least 12 weeks of continuous pravastatin or simvastatin therapy, the drugs were washed out for 12 weeks and replaced with fluvastatin (30 mg/day), then the treatment was continued for another 12 weeks. Total cholesterol and LDL cholesterol were efficiently and comparably reduced by all three statin agents. There were no differences in serum parameters of oxidative stress such as malondialdehyde-modified low-density lipoprotein, thiobarbituric acid-reactive substances, and 8-iso-prostaglandin F2a between pravastatin/simvastatin and fluvastatin. However, fluvastatin, but not pravastatin/simvastatin, significantly reduced 3,5,7-cholestatriene in erythrocyte membrane, representing the extent of membrane cholesterol peroxidation. Our data demonstrated that fluvastatin has a unique anti-oxidative effect in patients with type 2 diabetes and hyperlipidemia, compared with other statins.

Statins inhibit expression of Thioredoxin reductase 1 in rat and human liver and reduce tumour development

“…As discussed more thoroughly in Paper III, the antioxidative capacity of fluvastatin has been reported by others in other model systems, such as human aortic smooth muscle cells [173] and on the plasma lipids of hyperlipidemic subjects [174]. This is proposed to be a consequence of its unique structure compared to other statins, giving it a free radical-scavenging activity against the superoxide anion and hydroxyl radical [175,176] that is independent of its HMG-CoA reductase inhibition capacity [177].…”

Amelioration of Hyperglycaemia, Oxidative Stress and Dyslipidaemia in Alloxan-Induced Diabetic Wistar Rats Treated with Probiotic and Vitamin C

“…As a form of treatment in order to ameliorate the negative effect of oxidative stress, antioxidant therapy is a very promising intervention in minimizing the complications associated with oxidative stress in diabetes mellitus [ 31 , 32 ]. Thus, the present study showed that Vit-C decreased the blood glucose concentration in diabetic rats, and a more significant lowering-effect was recorded when probiotic and Vit-C were co-administered ( Table 1 ).…”

Atorvastatin Increases Myocardial Indices of Oxidative Stress in a Porcine Model of Hypercholesterolemia and Chronic Ischemia

“…Statins have been widely reported on for their antioxidant properties based on assessment of oxidative stress biomarkers in readily accessible fluids such as blood, 17–19 plasma, 20,21 serum, 22 and urine 23,24 . Although thought to reflect generalized oxidative stress status, a study investigating the specific relationship between peripheral (fluid) and tissue levels of oxidative stress demonstrated peripheral levels of oxidative stress biomarkers do not correlate with tissue levels and may not reflect the local oxidative stress status of individual organs 25 .…”