Anti-oxidative and anti-inflammatory activities of caffeoyl derivatives from the barks of Ilex rotunda

Kim, M; Choi, Seongkyu; K, Park; Kwon, Jin A; Oh, Min Hyuck; Kim, H; Jang, Ji-Su; Choe, Kwang-Ryul; Park, S; Lee, M

doi:10.1055/s-0031-1282545

Cited by 7 publications

(3 citation statements)

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“…One of the isoprene derivatives, bromo-3-methyl-2-butene, ordinarily known as prenyl bromide, can be utilized in place of a prenyl substrate in a variety of inorganic and organic compound syntheses [24]. Hemiterpene derivatives identified as hemiterpene glycoside were extracted from several floras such as Spiraea prunifolia [25,26], Megoura crassicauda [27], Securidaca inappendiculata [28,29], Ilex rotunda [30], Ilex pubescens [31,32], and Spiraea canescens [33]. They are mostly used in the treatment of autoimmune diseases such as rheumatoid stiffness (RA) and inflammation [34].…”

Section: Hemiterpenementioning

confidence: 99%

Total Synthesis of Terpenes and Their Biological Significance: A Critical Review

et al. 2022

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Section: Hemiterpenementioning

confidence: 99%

Total Synthesis of Terpenes and Their Biological Significance: A Critical Review

et al. 2022

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“…Mah SH and his colleagues found that aqueous extract of Polygonum chinense L. had good effect in inhibiting inflammatory response [ 11 ]. Meanwhile, Ilex rotunda Thumb also had antibacterial and anti-inflammatory activities [ 12 ]. Bacterial infection and inflammatory are two main pathogenesis of PID; however, it is yet to be determined whether FYCWYC maintains strong antibacterial and anti-inflammatory activities and has some effects on PID.…”

Section: Introductionmentioning

confidence: 99%

Anti‐Inflammatory Effect of Feiyangchangweiyan Capsule on Rat Pelvic Inflammatory Disease through JNK/NF‐κB Pathway

Liu

Yang

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Objectives In this study, we aimed to illustrate the preventive effect and possible mechanisms of Feiyangchangweiyan capsule (FYCWYC) on rat pelvic inflammatory disease (PID) model. Methods To construct the rat PID model, upper genital tract was infected by multipathogen, and then drugs were orally administered for 8 days. The histological examination, immunohistochemical analysis, and ELISA were carried out. Furthermore, Western blotting was used to analyze the expression of Akt, MAPKs, NF-κB p65, and IκB-α in uterus. Results As the results showed, infiltrations of neutrophils and lymphocytes in uterus were significantly suppressed, and IL-1β, IL-6, CXCL-1, and TNF-α were also reduced in a dose-dependent manner. We also found that FYCWYC inhibited apoptosis induced by infection. Furthermore, FYCWYC could block the infection-induced nuclear translocation of NF-κB. We found that FYCWYC treatment only decreased the phosphorylation of JNK induced by infection and had no effects on Akt and P38. Additional, the effects of SP600125, an inhibitor of phospho-JNK, were similar to the results of FYCWYC. Conclusions Taken together, our results demonstrated that FYCWYC had anti-inflammatory effect in pathogen-induced PID model, and the mechanism might be through inhibiting NF-κB nuclear translocation which is mediated by JNK.

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“…For example, the barks of Ilex rotunda , which is called “Jiu Bi Ying” in China, are officially recorded in the Chinese Pharmacopoeia and used to treat common colds, tonsillitis, eczema, and stomach and intestinal ulcers [2]. Previous studies have shown that the Ilex rotunda extract (IRE) has garnered considerable attention for its anti-inflammatory [3], antihypertensive [4], antibacterial [5], and antioxidant activities [6], as well as cardiovascular protection effects [7,8].…”

Section: Introductionmentioning

confidence: 99%

LC-MS/MS Determination and Pharmacokinetic Study of Pedunculoside in Rat Plasma after Oral Administration of Pedunculoside and Ilex rotunda Extract

Zhao

Pang

et al. 2015

Molecules

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Ilex rotunda is widely used to treat many disorders as a traditional Chinese medicine (TCM) containing 4%-5% pedunculoside (PDC). A rapid, selective, and sensitive liquid chromatography-tandem mass spectrometry method (LC-MS/MS) was developed and validated to determine PDC in rat plasma by using 3β,19α-dihydroxyurs-12-en-28-oic acid 28-β-D-glucopyranosyl ester (DEOG) as an internal standard. The analytes were extracted by protein precipitation and eluted on a C18 chromatography column using a mobile phase of methanol-H2O (70:30, v/v) delivered at a flow rate of 0.6 mL/min. Detection was performed using positive ion electrospray ionization in multiple reaction monitoring modes. The assay was linear over the concentration range of 0.60 ng/mL to 200 ng/mL, with a quantification limit of 0.60 ng/mL. Intra-day and inter-day precisions (%RSD) ranged from 2.12 to 9.51 for PDC, whereas the accuracy was within -7.83%~9.40%. The validated method was successfully applied to the pharmacokinetic study of PDC in rat plasma after oral administration of pure PDC and Ilex rotunda extract (IRE). Pharmacokinetic parameters of PDC in IRE, such as Cmax, AUC0-t, AUC0-∞, t1/2z, and CLz/F, statistically differed from those of the pure monomer (p < 0.01). However, Tmax and MRT showed no significant differences between the two groups. Results suggested that other coexisting components in IRE may decrease the absorption of PDC. Compound-compound interactions between PDC and other herbal extract components can alter the pharmacokinetic behavior of PDC. The study will be helpful in providing references for understanding the action mechanism and clinical application of Ilex rotunda.

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Anti-oxidative and anti-inflammatory activities of caffeoyl derivatives from the barks of Ilex rotunda

Cited by 7 publications

References 0 publications

Total Synthesis of Terpenes and Their Biological Significance: A Critical Review

Total Synthesis of Terpenes and Their Biological Significance: A Critical Review

Anti‐Inflammatory Effect of Feiyangchangweiyan Capsule on Rat Pelvic Inflammatory Disease through JNK/NF‐κB Pathway

LC-MS/MS Determination and Pharmacokinetic Study of Pedunculoside in Rat Plasma after Oral Administration of Pedunculoside and Ilex rotunda Extract

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