Anti-oxidant activity, phytochemical screening and HPLC profile of rare endemic Cordia diffusa

Prabu, K.; Rajasekaran, Arunachalam; Bharathi, Devaraj; Subbiah, Ramalakshmi

doi:10.1016/j.jksus.2018.04.025

Cited by 15 publications

(4 citation statements)

References 17 publications

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“…The quantified metabolites in C. glabrata were the ferulic acid, p-cumáric acid and caffeic acid, as already reported in other species of the genus Cordia, such as gallic and caffeic acid found in C. verbenacea (Matias et al, 2015), ferulic acid in C. diffusa, (Prabu et al, 2018), quercetin and apigenin in C. dichotoma, (Rahman and Akhtar, 2016) and kaempferol in C. sinensis (Al-Musayeib et al, 2011). According to some authors, it is suggested that gallic acid, ferulic acid, p-cumaric acid, caffeic acid, quercetin, and apigenin have a direct role in antioxidant, antiviral, antimicrobial, and photoprotective processes (Nicácio et al, 2017).…”

Section: Discussionsupporting

confidence: 69%

“…Phenolic compounds are commonly found in the plantae kingdom and are important due to their different biological activities such as antioxidant, anti-inflammatory, antimicrobial, antiviral and photoprotective (Nicácio et al, 2017). Prabu et al (2018) worked with methanolic extracts from Cordia diffusa leaves and found values of 5.03 ± 0.50 µgmL -1 for phenolic compounds and 5.65 ± 0.43 µgmL -1 for flavonoids, while Santi et al (2014) found values of 79.48 ± 0.63 mgEAG g -1 for phenols and 65.03 ± 4.59 mgEQ g -1 for flavonoids in ethanolic extracts of C. verbenacea leaves. The results for C. glabrata were higher, with values from 17.13 to 26.04 µgmL -1 of phenols and 5.85 to 10.30 µgmL -1 for flavonoids.…”

Section: Discussionmentioning

confidence: 99%

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Phytochemical screening of Cordia glabrata (MART.) A.DC. extracts and its potential antioxidant, photoprotective, antimicrobial and antiviral activities

et al. 2023

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Species of the genus Cordia have shown biological activities, such as anti-inflammatory, analgesic, antioxidant, antiviral, and antifungal activities. The species Cordia glabrata (MART) A.DC. Has no information concerning its phytochemical profile and possible biological activities. Thus, this study aimed to evaluate this profile in ethanolic extracts of young, adult and senescent leaves, as well as their antioxidant, photoprotective, antimicrobial, and virucidal potentials. Phytochemical analysis was performed by TLC (thin-layer chromatography) and showed the presence of flavonoids, tannins, and terpenes. The evaluation by UPLC-MS/MS (Ultra performance liquid chromatography - tandem mass spectrometer) evidenced the presence of caffeic (3.89 mgL-1), p-cumaric (6.13 mgL-1), and ferulic (0.58 mgL-1) acids, whilst, in GC/MS (Gas chromatography–mass spectrometry) analysis there was a greater amount of palmitic (51.17%), stearic (20.34%), linoleic (9.62%), and miristic (8.16%) fatty acids. The DPPH (2,2-Diphenyl-1-picrylhydrazyl) and ABTS+ (2′-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)) radicals were used to verify the potential antioxidant activity, observing a better activity for the leaf extract in the adult phenological stage: 54.63 ± 1.06 µgmL-1 (DPPH) and 44.21 ± 1.69 mM (ABTS). The potential photoprotective activity of the extracts was determined by spectrophotometry and the in vitro values of SPF (Sun Protection Factor) in young and adult leaves (5.47 and 5.41, respectively) showed values close to the minimum SPF of 6.0 required by ANVISA (Brazilian Health Regulatory Agency). It was not observed an antimicrobial activity for Staphylococcus aureus with a minimum inhibitory concentration of 2000 μgmL-1, however the anti-herpetic assay against the Herpes simplex virus type 2 (HSV-2) showed a potent virucidal activity at the tested concentrations with CV50 value <0.195 μgmL-1 and a Selectivity Index (SI = CC50 / CV50) greater than 448. The results obtained in this study suggest that extracts of leaves of C. glabrata in their adult phenological stage have potential antioxidant, photoprotective and virucidal activity, considering in vitro test results.

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Section: Discussionsupporting

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Phytochemical screening of Cordia glabrata (MART.) A.DC. extracts and its potential antioxidant, photoprotective, antimicrobial and antiviral activities

et al. 2023

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“…A number of phytochemicals that have anti-diabetic properties present in medicinal plants have been discovered based on differences in chemical structure and have been classified as major groups [19,20]. The major groups of phytochemicals are alkaloids, aromatic acids, carotenoids, coumarins, essential oils, flavonoids, glycosides, organic acid, phenols and phenolics, phytosterols, protease inhibitors, saponins, steroids, tannins, terpenes, and terpenoids [21][22][23]. Recent pharmacological studies have revealed the anti-diabetic properties of medicinal plants and vitamins including anti-hyperglycemic, anti-lipidemic, hypoglycemic, and insulin mimicking [24,25].…”

Section: Introductionmentioning

confidence: 99%

The Management of Diabetes Mellitus Using Medicinal Plants and Vitamins

Yedjou,

Grigsby,

Mbemi

et al. 2023

IJMS

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Diabetes mellitus (DM) is a serious chronic metabolic disease that is associated with hyperglycemia and several complications including cardiovascular disease and chronic kidney disease. DM is caused by high levels of blood sugar in the body associated with the disruption of insulin metabolism and homeostasis. Over time, DM can induce life-threatening health problems such as blindness, heart disease, kidney damage, and stroke. Although the cure of DM has improved over the past decades, its morbidity and mortality rates remain high. Hence, new therapeutic strategies are needed to overcome the burden of this disease. One such prevention and treatment strategy that is easily accessible to diabetic patients at low cost is the use of medicinal plants, vitamins, and essential elements. The research objective of this review article is to study DM and explore its treatment modalities based on medicinal plants and vitamins. To achieve our objective, we searched scientific databases of ongoing trials in PubMed Central, Medline databases, and Google Scholar websites. We also searched databases on World Health Organization International Clinical Trials Registry Platform to collect relevant papers. Results of numerous scientific investigations revealed that phytochemicals present in medicinal plants (Allium sativum, Momordica charantia, Hibiscus sabdariffa L., and Zingiber officinale) possess anti-hypoglycemic activities and show promise for the prevention and/or control of DM. Results also revealed that intake of vitamins C, D, E, or their combination improves the health of diabetes patients by reducing blood glucose, inflammation, lipid peroxidation, and blood pressure levels. However, very limited studies have addressed the health benefits of medicinal plants and vitamins as chemo-therapeutic/preventive agents for the management of DM. This review paper aims at addressing this knowledge gap by studying DM and highlighting the biomedical significance of the most potent medicinal plants and vitamins with hypoglycemic properties that show a great potential to prevent and/or treat DM.

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“…Various disinfectants on the market can kill microbial pathogens or inhibit their growth, including some microorganisms. 2 A disinfectant can be categorized into three levels: a low level, a middle level (medium level) or an upper level. 3 A low level of disinfection should only be applied to unmedical devices and environmental areas that will come in contact with the skin.…”

Section: Introductionmentioning

confidence: 99%

Effects of storage conditions on superoxidised water

Sen,

Huat,

Andrianto

2023

MOJFPT

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Superoxidised water (SOW) in the food industry has several advantages over traditional chemical disinfectants. SOW is non-toxic and environmentally friendly and does not leave any harmful by-products. In addition, SOW is easy to use and can be applied to various food surfaces. SOW has been used to avoid the food industry's biological pollution caused by food-borne bacteria pathogens with recognized as a short producing time and evident in the sterilization process, SOW is highly recommended for its eco-friendly ability. Chlorine-containing solutions such as SOW are used for broad disinfection purposes, including in the food industry. Still, their effectiveness and stabilities often need to be investigated as residues such as chlorine in SOW are not stable. The efficacy of SOW can be easily affected by several factors, including pH, temperature, and organic matter content. In this study, the two different storage conditions influenced by the light exploration were used to investigate the light condition that directly impacts the chlorine level in SOW. Light intensity plays an important role in determining chlorine loss from SOW. Chlorine dissipation rates in the light condition are higher than in the dark condition. With the initial 40+0.00 mg/L of chlorine, the chlorine level was decreased as plastic bottle/light > glass bottle/light > plastic bottle/without light> glass bottle/without light. They show that the change in chlorine level is significantly influenced by the type of bottle and the environmental condition, such as light intensity, in this study. The results obtained in this study validate the practice of SOW’s storage condition to slow down chlorine's bulk decay when applied in various industries, such as the food industry.

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Anti-oxidant activity, phytochemical screening and HPLC profile of rare endemic Cordia diffusa

Cited by 15 publications

References 17 publications

Phytochemical screening of Cordia glabrata (MART.) A.DC. extracts and its potential antioxidant, photoprotective, antimicrobial and antiviral activities

Phytochemical screening of Cordia glabrata (MART.) A.DC. extracts and its potential antioxidant, photoprotective, antimicrobial and antiviral activities

The Management of Diabetes Mellitus Using Medicinal Plants and Vitamins

Effects of storage conditions on superoxidised water

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