Anti-oxidant activity in measles

Cemek, Mustafa; Bayiroğlu, Fahri; Çaksen, Hüseyîn; Cemek, Fatma; Dede, Semiha

doi:10.1179/146532805x58094

Cited by 4 publications

(4 citation statements)

References 20 publications

(15 reference statements)

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“…In previous studies in literature, Caksen et al 20 showed that although serum alpha-tocopherol, beta carotene, retinol, ascorbic acid, and glutathione levels were significantly higher in SSPE patients, glutathione level was significantly lower and the oxidative stress levels in the patient group were significantly increased compared to the control group. Cemek et al 18 examined the levels of enzymatic antioxidant parameters (superoxide dismutase, glutathione peroxidase, and catalase) and non-enzymatic antioxidant parameters (ceruloplasmin, albumin, total bilirubin, and uric acid) in children with measles and healthy control subjects. They also found that with the exception of albumin, the levels of the antioxidant parameters increased in the patients with measles compared to the control group.…”

Section: Discussionmentioning

confidence: 99%

“…In another 2 studies of patients with measles, oxidative stress levels were seen to be significantly increased in the patient group compared to the control group, which was in line with the findings of the current study. 18 , 19 Erbay et al 32 examined the plasma malondialdehyde (MDA), the serum carbonyl, and the plasma total sulfhydryl levels in 25 patients with measles and 25 healthy control subjects. From the study results it was reported that the plasma MDA and the serum carbonyl levels were higher in the patient group compared to the control group and the plasma sulfhydryl levels were lower in the patient group than in the control group.…”

Section: Discussionmentioning

confidence: 99%

“… 17 Oxidative stress has been shown to increase in children with measles with a breakdown of the oxidant/antioxidant balance system. 18 , 19 In literature, oxidative injury has been reported in patients with SSPE, 20 , 21 but there has been no explanatory study about the thiol–disulfide balance in measles. Therefore, the aim of this study was to determine the thiol-disulfide balance in children with measles, to evaluate how TAS, TOS, and OSI change in measles, and thereby contribute to the diagnosis and treatment methods that can be developed through the antioxidant pathway.…”

Section: Introductionmentioning

confidence: 99%

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A Predictor of Oxidative Stress in the Children with Measles: Thiol–Disulfide Homeostasi

Solmaz¹,

Ilter²,

Koyuncu³

et al. 2022

Turk Arch Pediatrics

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Objective: Measles is an infectious disease, in which oxidative stress increases. Thiols are an antioxidant substance which play a critical role in programmed cell death, detoxification, and regulation of cellular enzymatic activity, and the thiol–disulfide balance is associated with some diseases. The purpose of this study was to evaluate the thiol–disulfide balance in children with measles. Materials and Methods: This descriptive study included case and control groups. The plasma total oxidant status level was measured using the Erel method, and the groups were compared. Before the study, informed consent was obtained from patients and Ethics Committee approval was provided (No:17/Session:05, Date: May 2019). The Pearson’s and Fisher’s chi-square tests were applied in the comparisons of categorical data, and independent t -test/Mann–Whitney U tests were used to compare the patient and the control groups. Results: There were no significant differences between the patient-control groups in terms of age and gender ( P > .05). The total antioxidant status value was significantly lower, and the total oxidant status and oxidative stress index values were significantly higher ( P < .05) in the patient group compared to the control group. Native thiol, total thiol, and native thiol/total thiol percentage values were significantly lower, and the disulfide, disulfide/native thiol, and disulfide/total thiol percentage values were significantly higher ( P < .05) in the patients compared to the controls. Conclusions: The detection of oxidative stress in patients with measles is important, and these results show the possibility of using the thiol/disulfide homeostasis and oxidative stress index values as biomarkers of oxidative stress in patients with measles.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A Predictor of Oxidative Stress in the Children with Measles: Thiol–Disulfide Homeostasi

Solmaz¹,

Ilter²,

Koyuncu³

et al. 2022

Turk Arch Pediatrics

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“…All of these antioxidant activities except for albumin level were increased in children with measles. 14 We also measured malondialdehyde (as a marker of lipid peroxidation and indicator of oxidant activity), reduced glutathione, beta-carotene, retinol, alpha-tocopherol, and ascorbic acid levels in children with measles. Non-enzymatic antioxidant status was found to be decreased, but lipid peroxidation was increased in children with measles.…”

mentioning

confidence: 99%

Oxidant and Antioxidant Status in Children With Subacute Sclerosing Panencephalitis

et al. 2013

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We analyzed serum alpha-tocopherol, beta-carotene, retinol, and ascorbic acid levels and malondialdehyde and reduced glutathione concentrations on erythrocyte and cerebrospinal fluid in 30 patients with subacute sclerosing panencephalitis to evaluate oxidant and antioxidant status. Serum alpha-tocopherol, beta-carotene, retinol, ascorbic acid levels, and erythrocyte and cerebrospinal fluid reduced glutathione concentrations were decreased; however, erythrocyte and cerebrospinal fluid malondialdehyde levels were increased in the patients. Cerebrospinal fluid malondialdehyde levels were different between clinical stages of the disease (P < .05). Higher cerebrospinal fluid malondialdehyde level was associated with the more severe clinical stage. A positive correlation was found between cerebrospinal fluid malondialdehyde level and clinical stages (r = 0.42; P < .05) and between erythrocyte malondialdehyde level and clinical stages (r = 0.40; P < .05). Our findings showed presence of oxidative damage in subacute sclerosing panencephalitis and that antioxidants were increased as defense mechanisms of the organism against oxidative damage.

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Quality consistency evaluation of Isatidis Folium combined with equal weight quantified ratio fingerprint method and determination of antioxidant activity

Gong

Zhu

et al. 2018

Journal of Chromatography B

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Anti-oxidant activity in measles

Abstract: There was a statistically significant difference between the groups for all parameters. All of the anti-oxidant activities except for albumin level were increased in the study group. Both enzymatic and nonenzymatic anti-oxidant defence systems were affected in measles.

Cited by 4 publications

References 20 publications

A Predictor of Oxidative Stress in the Children with Measles: Thiol–Disulfide Homeostasi

A Predictor of Oxidative Stress in the Children with Measles: Thiol–Disulfide Homeostasi

Oxidant and Antioxidant Status in Children With Subacute Sclerosing Panencephalitis

Quality consistency evaluation of Isatidis Folium combined with equal weight quantified ratio fingerprint method and determination of antioxidant activity

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