Anti-obesity potential of Glycyrrhiza uralensis and licochalcone A through induction of adipocyte browning

Lee, Hye-Eun; Yang, Gabsik; Han, Sung-Hyun; Lee, Jeong-Hoon; An, Tae-Jin; Jang, Jae-Ki; Lee, Joo Young

doi:10.1016/j.bbrc.2018.07.168

Cited by 44 publications

(28 citation statements)

References 21 publications

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“…The treatment of obese mice with licochalcone F to reduced adipocyte size and ameliorated macrophage infiltration in WAT depots as well as enhanced Akt signaling and reduced p38 MAPK pathway [ 380 ]. On its side, the administration of Licochalcone A, isoliquiritigenin or a Glycyrrhiza uralensis extract containing licochalcone A, isoliquiritigenin, and liquiritigenin to diet-induced obese mice reduced body weight gain and adipose tissues depots [ 393 , 400 , 406 ]. In this case, Licochalcone A and Glycyrrhiza uralensis extract induced the browning phenotype in the iWAT this fat depot [ 393 , 406 ] as it is demonstrated by the enhanced expression of brown fat markers such as Ucp1, Prdm16 and Pgc1α [ 406 ].…”

Section: Chalconesmentioning

confidence: 99%

“…On its side, the administration of Licochalcone A, isoliquiritigenin or a Glycyrrhiza uralensis extract containing licochalcone A, isoliquiritigenin, and liquiritigenin to diet-induced obese mice reduced body weight gain and adipose tissues depots [ 393 , 400 , 406 ]. In this case, Licochalcone A and Glycyrrhiza uralensis extract induced the browning phenotype in the iWAT this fat depot [ 393 , 406 ] as it is demonstrated by the enhanced expression of brown fat markers such as Ucp1, Prdm16 and Pgc1α [ 406 ]. By contrast, isoliquiritigenin elevated energy expenditure by increasing the expression of thermogenic genes ( Ucp1 and Prdm16 ) as well as Sirt1 that is linked to mitochondrial biogenesis [ 407 ] in interscapular BAT [ 400 ].…”

Section: Chalconesmentioning

confidence: 99%

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Metabolic Impact of Flavonoids Consumption in Obesity: From Central to Peripheral

et al. 2020

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The prevention and treatment of obesity is primary based on the follow-up of a healthy lifestyle, which includes a healthy diet with an important presence of bioactive compounds such as polyphenols. For many years, the health benefits of polyphenols have been attributed to their anti-oxidant capacity as free radical scavengers. More recently it has been described that polyphenols activate other cell-signaling pathways that are not related to ROS production but rather involved in metabolic regulation. In this review, we have summarized the current knowledge in this field by focusing on the metabolic effects of flavonoids. Flavonoids are widely distributed in the plant kingdom where they are used for growing and defensing. They are structurally characterized by two benzene rings and a heterocyclic pyrone ring and based on the oxidation and saturation status of the heterocyclic ring flavonoids are grouped in seven different subclasses. The present work is focused on describing the molecular mechanisms underlying the metabolic impact of flavonoids in obesity and obesity-related diseases. We described the effects of each group of flavonoids in liver, white and brown adipose tissue and central nervous system and the metabolic and signaling pathways involved on them.

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Section: Chalconesmentioning

confidence: 99%

Section: Chalconesmentioning

confidence: 99%

Metabolic Impact of Flavonoids Consumption in Obesity: From Central to Peripheral

et al. 2020

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“…Liver tissue specimens were fixed in 10% buffered formalin, embedded in paraffin, cut into 3-µm-thick slices, and stained with hematoxylin and eosin (H&E) for the histological examination of liver tissue [39]. For detecting tissue protein expression, immunohistochemistry was performed [40]. To demonstrate fibrosis, liver sections were stained 2 h with Masson's trichrome reagent [41].…”

Section: Histological Analysismentioning

confidence: 99%

Sweroside Prevents Non-Alcoholic Steatohepatitis by Suppressing Activation of the NLRP3 Inflammasome

Yang

Jang

Kim

et al. 2020

IJMS

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Non-alcoholic steatohepatitis (NASH), a type of non-alcoholic fatty liver disease, is characterized as steatosis and inflammation in the liver. NLRP3 inflammasome activation is associated with NASH pathology. We hypothesized that suppressing the NLRP3 inflammasome could be effective in preventing NASH. We searched substances that could inhibit the activation of the NLRP3 inflammasome and identified sweroside as an NLRP3 inhibitor. We investigated whether sweroside can be applied to prevent the pathological symptoms associated with NASH in a methionine–choline-deficient (MCD) diet-induced NASH mouse model. The activation of the NLRP3 inflammasome was determined by detecting the production of caspase-1 and IL-1β from pro-caspase-1 and pro-IL-1β in primary mouse macrophages and mouse liver. In a NASH model, mice were fed an MCD diet for two weeks with daily intraperitoneal injections of sweroside. Sweroside effectively inhibited NLRP3 inflammasome activation in primary macrophages as shown by a decrease in IL-1β and caspase-1 production. In a MCD diet-induced NASH mouse model, intraperitoneal injection of sweroside significantly reduced serum aspartate transaminase and alanine transaminase levels, hepatic immune cell infiltration, hepatic triglyceride accumulation, and liver fibrosis. The improvement of NASH symptoms by sweroside was accompanied with its inhibitory effects on the hepatic NLRP3 inflammasome as hepatic IL-1β and caspase-1 were decreased. Furthermore, sweroside blocked de novo synthesis of mitochondrial DNA in the liver, contributing to suppression of the NLRP3 inflammasome. These results suggest that targeting the NLRP3 inflammasome with sweroside could be beneficially employed to improve NASH symptoms.

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“…Licochalcone A had an inhibitory effect on adipocyte differentiation and lipogenesis via the downregulation of PPAR-c, CCAAT/enhancer binding protein α (C/EBPα), and sterol regulatory element-binding protein 1c (SREBP-1c) in 3T3-L1 preadipocytes [112]. And other results demonstrated that licochalcone A was effective to reduce obesity and could recover metabolic homeostasis by inducing adipocyte browning [113].…”

Section: Antidiabetic Activitymentioning

confidence: 97%

Natural Chalcones in Chinese Materia Medica: Licorice

Wang

Liang

Zhang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Licorice is an important Chinese materia medica frequently used in clinical practice, which contains more than 20 triterpenoids and 300 flavonoids. Chalcone, one of the major classes of flavonoid, has a variety of biological activities and is widely distributed in nature. To date, about 42 chalcones have been isolated and identified from licorice. These chalcones play a pivotal role when licorice exerts its pharmacological effects. According to the research reports, these compounds have a wide range of biological activities, containing anticancer, anti-inflammatory, antimicrobial, antioxidative, antiviral, antidiabetic, antidepressive, hepatoprotective activities, and so on. This review aims to summarize structures and biological activities of chalcones from licorice. We hope that this work can provide a theoretical basis for the further studies of chalcones from licorice.

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Anti-obesity potential of Glycyrrhiza uralensis and licochalcone A through induction of adipocyte browning

Cited by 44 publications

References 21 publications

Metabolic Impact of Flavonoids Consumption in Obesity: From Central to Peripheral

Metabolic Impact of Flavonoids Consumption in Obesity: From Central to Peripheral

Sweroside Prevents Non-Alcoholic Steatohepatitis by Suppressing Activation of the NLRP3 Inflammasome

Natural Chalcones in Chinese Materia Medica: Licorice

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